Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Cortical microinfarcts in memory clinic patients are associated with reduced cerebral perfusion

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Glutamate levels and perfusion in pons during migraine attacks: A 3T MRI study using proton spectroscopy and arterial spin labeling

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. High spatiotemporal vessel-specific hemodynamic mapping with multi-echo single-vessel fMRI

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Modification of oxygen consumption and blood flow in mouse somatosensory cortex by cell-type-specific neuronal activity

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Validation of diffuse correlation spectroscopy against 15O-water PET for regional cerebral blood flow measurement in neonatal piglets

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Different preprocessing strategies lead to different conclusions: A [11C]DASB-PET reproducibility study

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Feasibility of Glutamate and GABA Detection in Pons and Thalamus at 3T and 7T by Proton Magnetic Resonance Spectroscopy

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Cerebral Oxygen Metabolism in Adults with Sickle Cell Disease

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Quantification of cerebral perfusion and cerebrovascular reserve using Turbo-QUASAR arterial spin labeling MRI

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Doeschka A Ferro
  • Henri Jjm Mutsaerts
  • Saima Hilal
  • Hugo J Kuijf
  • Esben T Petersen
  • Jan Petr
  • Susanne J van Veluw
  • Narayanaswamy Venketasubramanian
  • Tan Boon Yeow
  • Geert Jan Biessels
  • Christopher Chen
View graph of relations

Cerebral cortical microinfarcts (CMIs) are small ischemic lesions associated with cognitive impairment and dementia. CMIs are frequently observed in cortical watershed areas suggesting that hypoperfusion contributes to their development. We investigated if presence of CMIs was related to a decrease in cerebral perfusion, globally or specifically in cortex surrounding CMIs. In 181 memory clinic patients (mean age 72 ± 9 years, 51% male), CMI presence was rated on 3-T magnetic resonance imaging (MRI). Cerebral perfusion was assessed from cortical gray matter of the anterior circulation using pseudo-continuous arterial spin labeling parameters cerebral blood flow (CBF) (perfusion in mL blood/100 g tissue/min) and spatial coefficient of variation (CoV) (reflecting arterial transit time (ATT)). Patients with CMIs had a 12% lower CBF (beta = -.20) and 22% higher spatial CoV (beta = .20) (both p < .05) without a specific regional pattern on voxel-based CBF analysis. CBF in a 2 cm region-of-interest around the CMIs did not differ from CBF in a reference zone in the contralateral hemisphere. These findings show that CMIs in memory clinic patients are primarily related to global reductions in cerebral perfusion, thus shedding new light on the etiology of vascular brain injury in dementia.

Original languageEnglish
JournalJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
Volume40
Issue number9
Pages (from-to)1869-1878
Number of pages10
ISSN0271-678X
DOIs
Publication statusPublished - Sep 2020

    Research areas

  • Arterial spin labeling, cerebral perfusion, dementia, microinfarct, vascular cognitive impairment

ID: 58033464