TY - JOUR
T1 - Cortical Frontoparietal Network Dysfunction in CHMP2B-Frontotemporal Dementia
AU - Musaeus, Christian Sandøe
AU - Pedersen, Jette Stokholm
AU - Kjær, Troels Wesenberg
AU - Johannsen, Peter
AU - Waldemar, Gunhild
AU - Haverberg, Maria Joy Normann
AU - Bacher, Theis
AU - Nielsen, Jørgen Erik
AU - Roos, Peter
AU - FReJA Consortium
N1 - Copyright © 2021 Musaeus, Pedersen, Kjær, Johannsen, Waldemar, Haverberg, Bacher, Nielsen, Roos and The FReJA Consortium.
PY - 2021/9/13
Y1 - 2021/9/13
N2 - A rare cause of inherited frontotemporal dementia (FTD) is a mutation in the CHMP2B gene on chromosome 3 leading to the autosomal dominantly inherited FTD (CHMP2B-FTD). Since CHMP2B-FTD is clinically well-characterized, and patients show a distinct pattern of executive dysfunction, the condition offers possible insight in the early electroencephalographic (EEG) changes in the cortical networks. Specifically, EEG microstate analysis parses the EEG signals into topographies believed to represent discrete network activations. We investigated the EEG dynamics in patients with symptomatic CHMP2B-FTD (n = 5) as well as pre-symptomatic mutation carriers (n = 5) compared to non-carrier family members (n = 6). The data was parsed into four archetypal microstates and global power was calculated. A trend was found for lower occurrence in microstate D in CHMP2B-FTD (p-value = 0.177, F-value = 2.036). Patients with recent symptom onset (<1 year) showed an increased duration of microstate D, whereas patients who had been symptomatic for longer periods (>2 years) showed decreased duration. Patients with CHMP2B-FTD present with executive dysfunction, and microstate D has previously been shown to be associated with the fronto-parietal network. The biphasic pattern may represent the pathophysiological changes in brain dynamics during neurodegeneration, which may apply to other neurodegenerative diseases.
AB - A rare cause of inherited frontotemporal dementia (FTD) is a mutation in the CHMP2B gene on chromosome 3 leading to the autosomal dominantly inherited FTD (CHMP2B-FTD). Since CHMP2B-FTD is clinically well-characterized, and patients show a distinct pattern of executive dysfunction, the condition offers possible insight in the early electroencephalographic (EEG) changes in the cortical networks. Specifically, EEG microstate analysis parses the EEG signals into topographies believed to represent discrete network activations. We investigated the EEG dynamics in patients with symptomatic CHMP2B-FTD (n = 5) as well as pre-symptomatic mutation carriers (n = 5) compared to non-carrier family members (n = 6). The data was parsed into four archetypal microstates and global power was calculated. A trend was found for lower occurrence in microstate D in CHMP2B-FTD (p-value = 0.177, F-value = 2.036). Patients with recent symptom onset (<1 year) showed an increased duration of microstate D, whereas patients who had been symptomatic for longer periods (>2 years) showed decreased duration. Patients with CHMP2B-FTD present with executive dysfunction, and microstate D has previously been shown to be associated with the fronto-parietal network. The biphasic pattern may represent the pathophysiological changes in brain dynamics during neurodegeneration, which may apply to other neurodegenerative diseases.
UR - http://www.scopus.com/inward/record.url?scp=85115868053&partnerID=8YFLogxK
U2 - 10.3389/fnagi.2021.714220
DO - 10.3389/fnagi.2021.714220
M3 - Journal article
C2 - 34588974
SN - 1663-4365
VL - 13
SP - e714220
JO - Frontiers in Aging Neuroscience
JF - Frontiers in Aging Neuroscience
M1 - 714220
ER -