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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Correlation between immunoglobulin dose administered and plasma neutralization of streptococcal superantigens in patients with necrotizing soft tissue infections

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

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Analyses of plasma collected pre- and post-administration of intravenous immunoglobulin G (IVIG) from patients with Group A Streptococcus necrotizing soft tissue infections demonstrated a negative correlation between IVIG dose and toxin-triggered T-cell proliferation (r=-0.67, p<0.0001). One 25g-dose IVIG was sufficient to yield patient plasma neutralizing activity against streptococcal superantigens.

Original languageEnglish
JournalClinical infectious diseases : an official publication of the Infectious Diseases Society of America
Volume71
Issue number7
Pages (from-to)1772-1775
Number of pages4
ISSN1058-4838
DOIs
Publication statusPublished - 23 Oct 2020

    Research areas

  • Streptococcus pyogenes, intravenous immunoglobulin G, necrotizing fasciitis, necrotizing soft tissue infections, superantigens

ID: 59138287