Correlation between immunoglobulin dose administered and plasma neutralization of streptococcal superantigens in patients with necrotizing soft tissue infections

Helena Bergsten; Martin Bruun Madsen; Francois Bergey; Ole Hyldegaard; Steinar Skrede; Per Arnell; Oddvar Oppegaard; Andreas Itzek; Anders Perner; Mattias Svensson; Anna Norrby-Teglund; INFECT study group

doi:10.1093/cid/ciaa022

Correlation between immunoglobulin dose administered and plasma neutralization of streptococcal superantigens in patients with necrotizing soft tissue infections

Helena Bergsten, Martin Bruun Madsen, Francois Bergey, Ole Hyldegaard, Steinar Skrede, Per Arnell, Oddvar Oppegaard, Andreas Itzek, Anders Perner, Mattias Svensson, Anna Norrby-Teglund, INFECT study group

27 Citations (Scopus)

Abstract

Analyses of plasma collected pre- and post-administration of intravenous immunoglobulin G (IVIG) from patients with Group A Streptococcus necrotizing soft tissue infections demonstrated a negative correlation between IVIG dose and toxin-triggered T-cell proliferation (r=-0.67, p<0.0001). One 25g-dose IVIG was sufficient to yield patient plasma neutralizing activity against streptococcal superantigens.

Original language	English
Journal	Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Volume	71
Issue number	7
Pages (from-to)	1772-1775
Number of pages	4
ISSN	1058-4838
DOIs	https://doi.org/10.1093/cid/ciaa022
Publication status	Published - 1 Oct 2020

Keywords

Streptococcus pyogenes
intravenous immunoglobulin G
necrotizing fasciitis
necrotizing soft tissue infections
superantigens
S treptococcus pyogenes
Necrotizing soft tissue infections
Necrotizing fasciitis
Superantigens
Intravenous immunoglobulin G

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10.1093/cid/ciaa022

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Bergsten, H., Madsen, M. B., Bergey, F., Hyldegaard, O., Skrede, S., Arnell, P., Oppegaard, O., Itzek, A., Perner, A., Svensson, M., Norrby-Teglund, A., & INFECT study group (2020). Correlation between immunoglobulin dose administered and plasma neutralization of streptococcal superantigens in patients with necrotizing soft tissue infections. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 71(7), 1772-1775. https://doi.org/10.1093/cid/ciaa022

Correlation between immunoglobulin dose administered and plasma neutralization of streptococcal superantigens in patients with necrotizing soft tissue infections. / Bergsten, Helena; Madsen, Martin Bruun; Bergey, Francois et al.
In: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Vol. 71, No. 7, 01.10.2020, p. 1772-1775.

Research output: Contribution to journal › Journal article › Research › peer-review

Bergsten, H, Madsen, MB, Bergey, F, Hyldegaard, O, Skrede, S, Arnell, P, Oppegaard, O, Itzek, A, Perner, A, Svensson, M, Norrby-Teglund, A & INFECT study group 2020, 'Correlation between immunoglobulin dose administered and plasma neutralization of streptococcal superantigens in patients with necrotizing soft tissue infections', Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, vol. 71, no. 7, pp. 1772-1775. https://doi.org/10.1093/cid/ciaa022

Bergsten H, Madsen MB, Bergey F, Hyldegaard O, Skrede S, Arnell P et al. Correlation between immunoglobulin dose administered and plasma neutralization of streptococcal superantigens in patients with necrotizing soft tissue infections. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2020 Oct 1;71(7):1772-1775. doi: 10.1093/cid/ciaa022

Bergsten, Helena ; Madsen, Martin Bruun ; Bergey, Francois et al. / Correlation between immunoglobulin dose administered and plasma neutralization of streptococcal superantigens in patients with necrotizing soft tissue infections. In: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2020 ; Vol. 71, No. 7. pp. 1772-1775.

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AU - Skrede, Steinar

AU - Arnell, Per

AU - Oppegaard, Oddvar

AU - Itzek, Andreas

AU - Perner, Anders

AU - Svensson, Mattias

AU - Norrby-Teglund, Anna

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KW - necrotizing fasciitis

KW - necrotizing soft tissue infections

KW - superantigens

KW - S treptococcus pyogenes

KW - Necrotizing soft tissue infections

KW - Necrotizing fasciitis

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Correlation between immunoglobulin dose administered and plasma neutralization of streptococcal superantigens in patients with necrotizing soft tissue infections

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