Correlates for disease progression and prognosis during concurrent HIV/Infektion

Joel Fleury Djoba Siawaya; Morten Ruhwald; Jesper Eugen-Olsen; Gerhard Walzl

Correlates for disease progression and prognosis during concurrent HIV/Infektion

Joel Fleury Djoba Siawaya, Morten Ruhwald, Jesper Eugen-Olsen, Gerhard Walzl

Abstract

Mycobacterium tuberculosis (Mtb) and the human immunodeficiency virus (HIV) are both life-threatening pathogens in their own right, but their synergic effects on the immune system during co-infection markedly enhance their effect on the host. This review focuses on the bidirectional interaction between HIV and Mtb and discusses the relevance of sputum smear examination, CD4+ counts, viral load at baseline and after initiation of anti-retroviral therapy, as well as additional existing and new potential immune correlates of disease progression and prognosis. These markers include beta2-microglobulin, neopterin, tumor necrosis factor receptor II (TNFRII), CD8+/CD38+, soluble urokinase plasminogen activator receptor (suPAR) and CXCL10 (or IP-10).

Original language	English
Journal	Int J Infect Dis
Volume	11
Issue number	4
Pages (from-to)	289-99
Publication status	Published - 2007

Keywords

TB; HIV; Concurrent infection; Immune correlates; Progression; Prognosis

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Djoba Siawaya, JF, Ruhwald, M, Eugen-Olsen, J & Walzl, G 2007, 'Correlates for disease progression and prognosis during concurrent HIV/Infektion', Int J Infect Dis, vol. 11, no. 4, pp. 289-99. <http://www.ncbi.nlm.nih.gov/sites/entrez?Db=PubMed&Cmd=ShowDetailView&TermToSearch=17446108&ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum>

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title = "Correlates for disease progression and prognosis during concurrent HIV/Infektion",

abstract = "Mycobacterium tuberculosis (Mtb) and the human immunodeficiency virus (HIV) are both life-threatening pathogens in their own right, but their synergic effects on the immune system during co-infection markedly enhance their effect on the host. This review focuses on the bidirectional interaction between HIV and Mtb and discusses the relevance of sputum smear examination, CD4+ counts, viral load at baseline and after initiation of anti-retroviral therapy, as well as additional existing and new potential immune correlates of disease progression and prognosis. These markers include beta2-microglobulin, neopterin, tumor necrosis factor receptor II (TNFRII), CD8+/CD38+, soluble urokinase plasminogen activator receptor (suPAR) and CXCL10 (or IP-10).",

keywords = "TB; HIV; Concurrent infection; Immune correlates; Progression; Prognosis",

author = "\{Djoba Siawaya\}, \{Joel Fleury\} and Morten Ruhwald and Jesper Eugen-Olsen and Gerhard Walzl",

year = "2007",

language = "English",

volume = "11",

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journal = "Int J Infect Dis",

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T1 - Correlates for disease progression and prognosis during concurrent HIV/Infektion

AU - Djoba Siawaya, Joel Fleury

AU - Ruhwald, Morten

AU - Eugen-Olsen, Jesper

AU - Walzl, Gerhard

PY - 2007

Y1 - 2007

N2 - Mycobacterium tuberculosis (Mtb) and the human immunodeficiency virus (HIV) are both life-threatening pathogens in their own right, but their synergic effects on the immune system during co-infection markedly enhance their effect on the host. This review focuses on the bidirectional interaction between HIV and Mtb and discusses the relevance of sputum smear examination, CD4+ counts, viral load at baseline and after initiation of anti-retroviral therapy, as well as additional existing and new potential immune correlates of disease progression and prognosis. These markers include beta2-microglobulin, neopterin, tumor necrosis factor receptor II (TNFRII), CD8+/CD38+, soluble urokinase plasminogen activator receptor (suPAR) and CXCL10 (or IP-10).

AB - Mycobacterium tuberculosis (Mtb) and the human immunodeficiency virus (HIV) are both life-threatening pathogens in their own right, but their synergic effects on the immune system during co-infection markedly enhance their effect on the host. This review focuses on the bidirectional interaction between HIV and Mtb and discusses the relevance of sputum smear examination, CD4+ counts, viral load at baseline and after initiation of anti-retroviral therapy, as well as additional existing and new potential immune correlates of disease progression and prognosis. These markers include beta2-microglobulin, neopterin, tumor necrosis factor receptor II (TNFRII), CD8+/CD38+, soluble urokinase plasminogen activator receptor (suPAR) and CXCL10 (or IP-10).

KW - TB; HIV; Concurrent infection; Immune correlates; Progression; Prognosis

M3 - Review

SN - 1878-3511

VL - 11

SP - 289

EP - 299

JO - Int J Infect Dis

JF - Int J Infect Dis

IS - 4

ER -

Correlates for disease progression and prognosis during concurrent HIV/Infektion

Abstract

Keywords

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