Correlates for disease progression and prognosis during concurrent HIV/TB infection

Joel Fleury Djoba Siawaya; Morten Ruhwald; Jesper Eugen-Olsen; Gerhard Walzl

doi:10.1016/j.ijid.2007.02.001

Correlates for disease progression and prognosis during concurrent HIV/TB infection

Joel Fleury Djoba Siawaya, Morten Ruhwald, Jesper Eugen-Olsen, Gerhard Walzl

54 Citations (Scopus)

Abstract

Mycobacterium tuberculosis (Mtb) and the human immunodeficiency virus (HIV) are both life-threatening pathogens in their own right, but their synergic effects on the immune system during co-infection markedly enhance their effect on the host. This review focuses on the bidirectional interaction between HIV and Mtb and discusses the relevance of sputum smear examination, CD4+ counts, viral load at baseline and after initiation of anti-retroviral therapy, as well as additional existing and new potential immune correlates of disease progression and prognosis. These markers include beta2-microglobulin, neopterin, tumor necrosis factor receptor II (TNFRII), CD8+/CD38+, soluble urokinase plasminogen activator receptor (suPAR) and CXCL10 (or IP-10).

Original language	English
Journal	International Journal of Infectious Diseases
Volume	11
Issue number	4
Pages (from-to)	289-99
Number of pages	10
ISSN	1201-9712
DOIs	https://doi.org/10.1016/j.ijid.2007.02.001
Publication status	Published - 2007

Keywords

Cytokines
Dendritic Cells
Disease Progression
HIV
HIV Infections
Humans
Mycobacterium tuberculosis
Prognosis
Tuberculosis

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10.1016/j.ijid.2007.02.001

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title = "Correlates for disease progression and prognosis during concurrent HIV/TB infection",

abstract = "Mycobacterium tuberculosis (Mtb) and the human immunodeficiency virus (HIV) are both life-threatening pathogens in their own right, but their synergic effects on the immune system during co-infection markedly enhance their effect on the host. This review focuses on the bidirectional interaction between HIV and Mtb and discusses the relevance of sputum smear examination, CD4+ counts, viral load at baseline and after initiation of anti-retroviral therapy, as well as additional existing and new potential immune correlates of disease progression and prognosis. These markers include beta2-microglobulin, neopterin, tumor necrosis factor receptor II (TNFRII), CD8+/CD38+, soluble urokinase plasminogen activator receptor (suPAR) and CXCL10 (or IP-10).",

keywords = "Cytokines, Dendritic Cells, Disease Progression, HIV, HIV Infections, Humans, Mycobacterium tuberculosis, Prognosis, Tuberculosis",

author = "{Djoba Siawaya}, {Joel Fleury} and Morten Ruhwald and Jesper Eugen-Olsen and Gerhard Walzl",

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T1 - Correlates for disease progression and prognosis during concurrent HIV/TB infection

AU - Djoba Siawaya, Joel Fleury

AU - Ruhwald, Morten

AU - Eugen-Olsen, Jesper

AU - Walzl, Gerhard

PY - 2007

Y1 - 2007

N2 - Mycobacterium tuberculosis (Mtb) and the human immunodeficiency virus (HIV) are both life-threatening pathogens in their own right, but their synergic effects on the immune system during co-infection markedly enhance their effect on the host. This review focuses on the bidirectional interaction between HIV and Mtb and discusses the relevance of sputum smear examination, CD4+ counts, viral load at baseline and after initiation of anti-retroviral therapy, as well as additional existing and new potential immune correlates of disease progression and prognosis. These markers include beta2-microglobulin, neopterin, tumor necrosis factor receptor II (TNFRII), CD8+/CD38+, soluble urokinase plasminogen activator receptor (suPAR) and CXCL10 (or IP-10).

AB - Mycobacterium tuberculosis (Mtb) and the human immunodeficiency virus (HIV) are both life-threatening pathogens in their own right, but their synergic effects on the immune system during co-infection markedly enhance their effect on the host. This review focuses on the bidirectional interaction between HIV and Mtb and discusses the relevance of sputum smear examination, CD4+ counts, viral load at baseline and after initiation of anti-retroviral therapy, as well as additional existing and new potential immune correlates of disease progression and prognosis. These markers include beta2-microglobulin, neopterin, tumor necrosis factor receptor II (TNFRII), CD8+/CD38+, soluble urokinase plasminogen activator receptor (suPAR) and CXCL10 (or IP-10).

KW - Cytokines

KW - Dendritic Cells

KW - Disease Progression

KW - HIV

KW - HIV Infections

KW - Humans

KW - Mycobacterium tuberculosis

KW - Prognosis

KW - Tuberculosis

U2 - 10.1016/j.ijid.2007.02.001

DO - 10.1016/j.ijid.2007.02.001

M3 - Journal article

C2 - 17446108

VL - 11

SP - 289

EP - 299

JO - International Journal of Infectious Diseases

JF - International Journal of Infectious Diseases

SN - 1201-9712

IS - 4

ER -

Correlates for disease progression and prognosis during concurrent HIV/TB infection

Abstract

Keywords

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