Correlates for disease progression and prognosis during concurrent HIV/TB infection

Joel Fleury Djoba Siawaya, Morten Ruhwald, Jesper Eugen-Olsen, Gerhard Walzl

54 Citations (Scopus)


Mycobacterium tuberculosis (Mtb) and the human immunodeficiency virus (HIV) are both life-threatening pathogens in their own right, but their synergic effects on the immune system during co-infection markedly enhance their effect on the host. This review focuses on the bidirectional interaction between HIV and Mtb and discusses the relevance of sputum smear examination, CD4+ counts, viral load at baseline and after initiation of anti-retroviral therapy, as well as additional existing and new potential immune correlates of disease progression and prognosis. These markers include beta2-microglobulin, neopterin, tumor necrosis factor receptor II (TNFRII), CD8+/CD38+, soluble urokinase plasminogen activator receptor (suPAR) and CXCL10 (or IP-10).
Original languageEnglish
JournalInternational Journal of Infectious Diseases
Issue number4
Pages (from-to)289-99
Number of pages10
Publication statusPublished - 2007


  • Cytokines
  • Dendritic Cells
  • Disease Progression
  • HIV
  • HIV Infections
  • Humans
  • Mycobacterium tuberculosis
  • Prognosis
  • Tuberculosis


Dive into the research topics of 'Correlates for disease progression and prognosis during concurrent HIV/TB infection'. Together they form a unique fingerprint.

Cite this