Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Coronary heart disease and heart failure in asthma, COPD and asthma-COPD overlap

Research output: Contribution to journalJournal articleResearchpeer-review

  1. High prevalence of exercise-induced stridor during Parkrun: a cross-sectional field-based evaluation

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. 'Reduced' HUNT model outperforms NLST and NELSON study criteria in predicting lung cancer in the Danish screening trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. HIV infection is associated with type 2 diabetes mellitus

    Research output: Contribution to journalLetterResearchpeer-review

  2. Common variants in Alzheimer's disease and risk stratification by polygenic risk scores

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Trajectory of Preserved Ratio Impaired Spirometry: Natural History and Long-Term Prognosis

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

INTRODUCTION: We investigated risk of coronary heart disease and heart failure in phenotypes of obstructive airway disease.

METHODS: Among 91 692 participants in the Copenhagen General Population Study, 42 058 individuals were classified with no respiratory disease, and 11 988 individuals had different phenotypes of obstructive airways disease: asthma with early onset or late-onset, chronic obstructive pulmonary disease (COPD) with forced expiratory volume in one second (FEV1) above or below 50% of predicted value (%p) or asthma-COPD overlap (ACO).

RESULTS: During a mean follow-up of 5.7 years we registered 3584 admissions for coronary heart disease and 1590 admissions for heart failure. Multivariable Cox regression analyses of time to first admission were used with a two-sided p value of 0.05 as significance level. Compared with no respiratory disease the highest risks of coronary heart disease and heart failure were observed in ACO with late-onset asthma and FEV1 <50% p, HR=2.2 (95% CI 1.6 to 3.0), and HR=2.9 (95% CI 2.0 to 4.3), respectively. In COPD with FEV1 above 50% p the HRs were 1.3 (95% CI 1.2 to 1.5) for coronary heart disease and 1.9 (95% CI 1.6 to 2.3) for heart failure. Asthma associated with increased risks of coronary heart disease and heart failure, however, in asthma without allergy the HR was 1.1 (95% CI 0.7 to 1.6) for coronary heart disease while individuals with allergy had an HR of 1.4 (95% CI 1.1 to 1.6).

CONCLUSIONS: Risks of coronary heart disease and heart failure were increased in asthma, COPD and ACO. In asthma, the risk of coronary heart disease depended on presence of allergy. We suggest that cardiovascular risk factors should be assessed systematically in individuals with obstructive airway disease with the potential to facilitate targeted treatments.

Original languageEnglish
Article numbere000470
JournalBMJ Open Respiratory Research
Volume7
Issue number1
ISSN2052-4439
DOIs
Publication statusPublished - Feb 2020

    Research areas

  • clinical epidemiology, COPD epidemiology

ID: 61899005