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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Copy Number Variants and Polygenic Risk Scores Predict Need of Care in Autism and/or ADHD Families

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  1. Brief Report: Clusters and Trajectories Across the Autism and/or ADHD Spectrum

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  2. Epilepsy in Individuals with a History of Asperger's Syndrome: A Danish Nationwide Register-Based Cohort Study

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  1. A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasis

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  2. Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder

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  3. Exploring Movement Impairments in Patients With Parkinson's Disease Using the Microsoft Kinect Sensor: A Feasibility Study

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Autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) are highly heritable neurodevelop-mental disorders that frequently co-occur. Both rare and common genetic variants are important for ASD and ADHD risk but their combined contribution to clinical heterogeneity is unclear.In a sample of 39 ASD and/or ADHD families we estimated the overall variance explained by known rare copy number variants (CNVs) and polygenic risk score (PRS) from common variants to be10% in comorbid ASD/ADHD, 4% in ASD and 2% in ADHD. We show that burden of large, rare CNVs and PRS is significantly higher in adult ASD and/or ADHD patients with sustained need for specialist care compared to their unaffected relatives, while affected relatives fall in-between the two.
Original languageDanish
JournalJournal of Autism and Developmental Disorders
Volume51
Issue number1
Pages (from-to)276-285
Number of pages10
ISSN0162-3257
Publication statusPublished - Jan 2021

ID: 59938050