Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Contrast-enhanced ultrasound using bolus injections of contrast agent for assessment of postprandial microvascular blood volume in human skeletal muscle

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Myocardial perfusion assessed with cardiac computed tomography in women without coronary heart disease

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Cardiometabolic effects of antidiabetic drugs in non-alcoholic fatty liver disease

    Research output: Contribution to journalReviewResearchpeer-review

  3. Validation of non-invasive haemodynamic methods in patients with liver disease: the Finometer and the Task Force Monitor

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. I-MIBG imaging for detection of anthracycline-induced cardiomyopathy

    Research output: Contribution to journalReviewResearchpeer-review

  5. (18) F-FDG PET/CT for planning external beam radiotherapy alters therapy in 11% of 581 patients

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. An exploration of the methods to determine the protein-specific synthesis and breakdown rates in vivo in humans

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Postprandial Nutrient Handling and Gastrointestinal Hormone Secretion After Roux-en-Y Gastric Bypass vs Sleeve Gastrectomy

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Effect of Losartan on the Acute Response of Human Elderly Skeletal Muscle to Exercise

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Methods capable of measuring blood flow in a tissue-specific manner are needed. The purpose of this study was to investigate whether contrast-enhanced ultrasound (CEUS) using bolus injections of SonoVue® is an useful method for assessing postprandial changes in microvascular perfusion in the vastus lateralis muscle. Ten healthy, young subjects were recruited for this study. Six subjects participated in washout and reproducibility protocols to assess washout time of SonoVue® and the reproducibility of the method when measuring microvascular blood volume (MBV). Six subjects (two of which also participated in the washout and reproducibility protocols) participated in exercise and nutrition protocols, to assess the ability of the method to detect changes in MBV in response to these interventions. Intraday variation (coefficients of variation) for MBV indices, as assessed by peak signal intensity (PI) or mean plateau signal intensity (mPI), was high (PI: 19 ± 4·2%; mPI: 23 ± 3·3%). The exercise protocol induced significant increases in MBV indices (PI:+113%, P˂0·0001; mPI:+218%, P˂0·0001) acutely after exercise cessation. There were no changes in MBV indices in response to feeding during the nutrition protocol (PI: P = 0·51; mPI: P = 0·51). We conclude that CEUS using bolus injections of SonoVue® is not capable of detecting changes in MBV of vastus lateralis in response to feeding. This is probably due to the low reproducibility of the method. However, the method is capable of measuring changes in MBV in response to exercise. This method could therefore be used when investigating exercise-induced changes in microvascular perfusion.

Original languageEnglish
JournalClinical Physiology and Functional Imaging
Volume38
Issue number5
Pages (from-to)864-871
Number of pages8
ISSN1475-0961
DOIs
Publication statusPublished - Sep 2018

    Research areas

  • Adult, Blood Volume, Blood Volume Determination/methods, Contrast Media/administration & dosage, Female, Humans, Injections, Intravenous, Male, Microbubbles, Microcirculation, Microvessels/diagnostic imaging, Muscle Strength, Nutritional Status, Perfusion Imaging/methods, Phospholipids/administration & dosage, Postprandial Period, Predictive Value of Tests, Quadriceps Muscle/blood supply, Reproducibility of Results, Sulfur Hexafluoride/administration & dosage, Time Factors, Ultrasonography, Young Adult

ID: 56334415