Contralateral breast cancer after radiotherapy among BRCA1 and BRCA2 mutation carriers: a WECARE study report

Jonine L Bernstein; Duncan C Thomas; Roy E Shore; Mark Robson; John D Boice; Marilyn Stovall; Michael Andersson; Leslie Bernstein; Kathleen E Malone; Anne S Reiner; Charles F Lynch; Marinela Capanu; Susan A Smith; Lina Tellhed; Sharon N Teraoka; Colin B Begg; Jorgen H Olsen; Lene Mellemkjaer; Xiaolin Liang; Anh T Diep; Ake Borg; Patrick Concannon; Robert W Haile; WECARE Study Collaborative Group

doi:10.1016/j.ejca.2013.04.028

Contralateral breast cancer after radiotherapy among BRCA1 and BRCA2 mutation carriers: a WECARE study report

Jonine L Bernstein, Duncan C Thomas, Roy E Shore, Mark Robson, John D Boice, Marilyn Stovall, Michael Andersson, Leslie Bernstein, Kathleen E Malone, Anne S Reiner, Charles F Lynch, Marinela Capanu, Susan A Smith, Lina Tellhed, Sharon N Teraoka, Colin B Begg, Jorgen H Olsen, Lene Mellemkjaer, Xiaolin Liang, Anh T DiepAke Borg, Patrick Concannon, Robert W Haile, WECARE Study Collaborative Group

74 Citations (Scopus)

Abstract

Women with germline BRCA1 or BRCA2 (BRCA1/BRCA2) mutations are at very high risk of developing breast cancer, including asynchronous contralateral breast cancer (CBC). BRCA1/BRCA2 genes help maintain genome stability and assist in DNA repair. We examined whether the risk of CBC associated with radiation treatment was higher among women with germline BRCA1/BRCA2 mutations than among non-carriers.

Original language	English
Journal	European journal of cancer (Oxford, England : 1990)
Volume	49
Issue number	14
Pages (from-to)	2979-85
Number of pages	7
ISSN	0959-8049
DOIs	https://doi.org/10.1016/j.ejca.2013.04.028
Publication status	Published - Sept 2013

Keywords

Adult
BRCA1 Protein
BRCA2 Protein
Breast
Breast Neoplasms
Case-Control Studies
Cohort Studies
Female
Genetic Predisposition to Disease
Heterozygote
Humans
Logistic Models
Middle Aged
Multivariate Analysis
Radiation Dosage
Risk Factors

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Bernstein, J. L., Thomas, D. C., Shore, R. E., Robson, M., Boice, J. D., Stovall, M., Andersson, M., Bernstein, L., Malone, K. E., Reiner, A. S., Lynch, C. F., Capanu, M., Smith, S. A., Tellhed, L., Teraoka, S. N., Begg, C. B., Olsen, J. H., Mellemkjaer, L., Liang, X., ... WECARE Study Collaborative Group (2013). Contralateral breast cancer after radiotherapy among BRCA1 and BRCA2 mutation carriers: a WECARE study report. European journal of cancer (Oxford, England : 1990), 49(14), 2979-85. https://doi.org/10.1016/j.ejca.2013.04.028

Bernstein, JL, Thomas, DC, Shore, RE, Robson, M, Boice, JD, Stovall, M, Andersson, M, Bernstein, L, Malone, KE, Reiner, AS, Lynch, CF, Capanu, M, Smith, SA, Tellhed, L, Teraoka, SN, Begg, CB, Olsen, JH, Mellemkjaer, L, Liang, X, Diep, AT, Borg, A, Concannon, P, Haile, RW & WECARE Study Collaborative Group 2013, 'Contralateral breast cancer after radiotherapy among BRCA1 and BRCA2 mutation carriers: a WECARE study report', European journal of cancer (Oxford, England : 1990), vol. 49, no. 14, pp. 2979-85. https://doi.org/10.1016/j.ejca.2013.04.028

@article{6f43ec122f5945359ad735dfb418b107,

title = "Contralateral breast cancer after radiotherapy among BRCA1 and BRCA2 mutation carriers: a WECARE study report",

abstract = "Women with germline BRCA1 or BRCA2 (BRCA1/BRCA2) mutations are at very high risk of developing breast cancer, including asynchronous contralateral breast cancer (CBC). BRCA1/BRCA2 genes help maintain genome stability and assist in DNA repair. We examined whether the risk of CBC associated with radiation treatment was higher among women with germline BRCA1/BRCA2 mutations than among non-carriers.",

keywords = "Adult, BRCA1 Protein, BRCA2 Protein, Breast, Breast Neoplasms, Case-Control Studies, Cohort Studies, Female, Genetic Predisposition to Disease, Heterozygote, Humans, Logistic Models, Middle Aged, Multivariate Analysis, Radiation Dosage, Risk Factors",

author = "Bernstein, \{Jonine L\} and Thomas, \{Duncan C\} and Shore, \{Roy E\} and Mark Robson and Boice, \{John D\} and Marilyn Stovall and Michael Andersson and Leslie Bernstein and Malone, \{Kathleen E\} and Reiner, \{Anne S\} and Lynch, \{Charles F\} and Marinela Capanu and Smith, \{Susan A\} and Lina Tellhed and Teraoka, \{Sharon N\} and Begg, \{Colin B\} and Olsen, \{Jorgen H\} and Lene Mellemkjaer and Xiaolin Liang and Diep, \{Anh T\} and Ake Borg and Patrick Concannon and Haile, \{Robert W\} and \{WECARE Study Collaborative Group\}",

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doi = "10.1016/j.ejca.2013.04.028",

language = "English",

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journal = "European journal of cancer (Oxford, England : 1990)",

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T2 - a WECARE study report

AU - Bernstein, Jonine L

AU - Thomas, Duncan C

AU - Shore, Roy E

AU - Robson, Mark

AU - Boice, John D

AU - Stovall, Marilyn

AU - Andersson, Michael

AU - Bernstein, Leslie

AU - Malone, Kathleen E

AU - Reiner, Anne S

AU - Lynch, Charles F

AU - Capanu, Marinela

AU - Smith, Susan A

AU - Tellhed, Lina

AU - Teraoka, Sharon N

AU - Begg, Colin B

AU - Olsen, Jorgen H

AU - Mellemkjaer, Lene

AU - Liang, Xiaolin

AU - Diep, Anh T

AU - Borg, Ake

AU - Concannon, Patrick

AU - Haile, Robert W

AU - WECARE Study Collaborative Group

PY - 2013/9

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N2 - Women with germline BRCA1 or BRCA2 (BRCA1/BRCA2) mutations are at very high risk of developing breast cancer, including asynchronous contralateral breast cancer (CBC). BRCA1/BRCA2 genes help maintain genome stability and assist in DNA repair. We examined whether the risk of CBC associated with radiation treatment was higher among women with germline BRCA1/BRCA2 mutations than among non-carriers.

AB - Women with germline BRCA1 or BRCA2 (BRCA1/BRCA2) mutations are at very high risk of developing breast cancer, including asynchronous contralateral breast cancer (CBC). BRCA1/BRCA2 genes help maintain genome stability and assist in DNA repair. We examined whether the risk of CBC associated with radiation treatment was higher among women with germline BRCA1/BRCA2 mutations than among non-carriers.

KW - Adult

KW - BRCA1 Protein

KW - BRCA2 Protein

KW - Breast

KW - Breast Neoplasms

KW - Case-Control Studies

KW - Cohort Studies

KW - Female

KW - Genetic Predisposition to Disease

KW - Heterozygote

KW - Humans

KW - Logistic Models

KW - Middle Aged

KW - Multivariate Analysis

KW - Radiation Dosage

KW - Risk Factors

UR - https://www.scopus.com/pages/publications/84883052621

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DO - 10.1016/j.ejca.2013.04.028

M3 - Journal article

C2 - 23706288

SN - 0959-8049

VL - 49

SP - 2979

EP - 2985

JO - European journal of cancer (Oxford, England : 1990)

JF - European journal of cancer (Oxford, England : 1990)

IS - 14

ER -

Contralateral breast cancer after radiotherapy among BRCA1 and BRCA2 mutation carriers: a WECARE study report

Abstract

Keywords

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