Contraction-induced myokine production and release: is skeletal muscle an endocrine organ?

Mark A Febbraio; Bente K Pedersen

doi:10.1097/00003677-200507000-00003

Contraction-induced myokine production and release: is skeletal muscle an endocrine organ?

338 Citations (Scopus)

Abstract

The concentration of plasma interleukin-6 (IL-6) increases during physical exercise, but until recently the cellular origin of this increase has been unknown. Recent work has identified that skeletal muscle is a major source of this increase and the release of IL-6 from muscle can mediate metabolic processes. IL-6 is, therefore, the first identified "myokine" released from muscle that can now be termed an endocrine organ.

Original language	English
Journal	Exercise and Sport Sciences Reviews
Volume	33
Issue number	3
Pages (from-to)	114-9
Number of pages	6
ISSN	0091-6331
DOIs	https://doi.org/10.1097/00003677-200507000-00003
Publication status	Published - Jul 2005
Externally published	Yes

Keywords

Cytokines/biosynthesis
Endocrine System/physiology
Humans
Interleukin-6/metabolism
Muscle Cells/metabolism
Muscle Contraction/physiology
Muscle, Skeletal/metabolism

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10.1097/00003677-200507000-00003

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title = "Contraction-induced myokine production and release: is skeletal muscle an endocrine organ?",

abstract = "The concentration of plasma interleukin-6 (IL-6) increases during physical exercise, but until recently the cellular origin of this increase has been unknown. Recent work has identified that skeletal muscle is a major source of this increase and the release of IL-6 from muscle can mediate metabolic processes. IL-6 is, therefore, the first identified {"}myokine{"} released from muscle that can now be termed an endocrine organ.",

keywords = "Cytokines/biosynthesis, Endocrine System/physiology, Humans, Interleukin-6/metabolism, Muscle Cells/metabolism, Muscle Contraction/physiology, Muscle, Skeletal/metabolism",

author = "Febbraio, \{Mark A\} and Pedersen, \{Bente K\}",

year = "2005",

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doi = "10.1097/00003677-200507000-00003",

language = "English",

volume = "33",

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journal = "Exercise and Sport Sciences Reviews",

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publisher = "Lippincott Williams and Wilkins",

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T1 - Contraction-induced myokine production and release

T2 - is skeletal muscle an endocrine organ?

AU - Febbraio, Mark A

AU - Pedersen, Bente K

PY - 2005/7

Y1 - 2005/7

N2 - The concentration of plasma interleukin-6 (IL-6) increases during physical exercise, but until recently the cellular origin of this increase has been unknown. Recent work has identified that skeletal muscle is a major source of this increase and the release of IL-6 from muscle can mediate metabolic processes. IL-6 is, therefore, the first identified "myokine" released from muscle that can now be termed an endocrine organ.

AB - The concentration of plasma interleukin-6 (IL-6) increases during physical exercise, but until recently the cellular origin of this increase has been unknown. Recent work has identified that skeletal muscle is a major source of this increase and the release of IL-6 from muscle can mediate metabolic processes. IL-6 is, therefore, the first identified "myokine" released from muscle that can now be termed an endocrine organ.

KW - Cytokines/biosynthesis

KW - Endocrine System/physiology

KW - Humans

KW - Interleukin-6/metabolism

KW - Muscle Cells/metabolism

KW - Muscle Contraction/physiology

KW - Muscle, Skeletal/metabolism

UR - https://www.scopus.com/pages/publications/22244477735

U2 - 10.1097/00003677-200507000-00003

DO - 10.1097/00003677-200507000-00003

M3 - Review

C2 - 16006818

SN - 0091-6331

VL - 33

SP - 114

EP - 119

JO - Exercise and Sport Sciences Reviews

JF - Exercise and Sport Sciences Reviews

IS - 3

ER -

Contraction-induced myokine production and release: is skeletal muscle an endocrine organ?

Abstract

Keywords

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