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Continuing decline in the prevalence of cerebral palsy in Denmark for birth years 2008–2013

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@article{fe930cf227414f758eafe92ddf531b68,
title = "Continuing decline in the prevalence of cerebral palsy in Denmark for birth years 2008–2013",
abstract = "Aim: To quantify and analyse the prevalence and clinical features of cerebral palsy (CP) in Denmark for birth years 2008–2013 and compare results with previous periods. Method: A nationwide register-based study covering all children with a confirmed diagnosis of CP born in Denmark. Information about CP subtype, aetiology and severity was collected from the Cerebral Palsy Follow-up Program and supplemented from medical files. Data from the Danish Medical Birth Register was included, and the results were compared to previous data from the Danish National Cerebral Palsy Register. Prevalence per 1000 live births and proportions were analysed using the Cochran-Armitage test for trend. Results: The period covered 368,618 live births and 636 children with CP, making the overall prevalence for the period 1.73 per 1000 live births. This was significantly lower than the prevalence of 1.99 for the previous period 1999–2007 (p = 0.004). The decline in prevalence between the two periods was mainly due to a decrease in children with bilateral spastic and dyskinetic CP born after 37 gestational weeks. The decline in prevalence was accompanied by a smaller proportion of children with associated impairment. Conclusion: We found a decrease in prevalence and severity in CP among Danish children. The decline was most pronounced in children born after 37 gestational weeks with severe subtypes of CP. National guidelines that recommend induction of labour before the completion of week 42 and therapeutic hypothermia for term neonates with hypoxic-ischaemic encephalopathy, may have contributed to the decline.",
keywords = "Bilateral spastic cerebral palsy, Cerebral palsy, Denmark, Post-term delivery, Prevalence, Severity",
author = "Larsen, {Mads Langager} and Gija Rackauskaite and Gorm Greisen and Bjarne Laursen and Peter Uldall and Lone Krebs and Hoei-Hansen, {Christina Engel}",
note = "Funding Information: This work was supported by the Ludvig and Sara Elsass Foundation ( 19-3-0283 ) and the Dagmar Marshall Foundation ( 50020 ). The funding parties did not have any involvement in the study. Publisher Copyright: {\textcopyright} 2020 European Paediatric Neurology Society Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
month = jan,
day = "1",
doi = "10.1016/j.ejpn.2020.10.003",
language = "English",
volume = "30",
pages = "155--161",
journal = "European Journal of Paediatric Neurology",
issn = "1090-3798",
publisher = "W.B./Saunders Co. Ltd",

}

RIS

TY - JOUR

T1 - Continuing decline in the prevalence of cerebral palsy in Denmark for birth years 2008–2013

AU - Larsen, Mads Langager

AU - Rackauskaite, Gija

AU - Greisen, Gorm

AU - Laursen, Bjarne

AU - Uldall, Peter

AU - Krebs, Lone

AU - Hoei-Hansen, Christina Engel

N1 - Funding Information: This work was supported by the Ludvig and Sara Elsass Foundation ( 19-3-0283 ) and the Dagmar Marshall Foundation ( 50020 ). The funding parties did not have any involvement in the study. Publisher Copyright: © 2020 European Paediatric Neurology Society Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/1/1

Y1 - 2021/1/1

N2 - Aim: To quantify and analyse the prevalence and clinical features of cerebral palsy (CP) in Denmark for birth years 2008–2013 and compare results with previous periods. Method: A nationwide register-based study covering all children with a confirmed diagnosis of CP born in Denmark. Information about CP subtype, aetiology and severity was collected from the Cerebral Palsy Follow-up Program and supplemented from medical files. Data from the Danish Medical Birth Register was included, and the results were compared to previous data from the Danish National Cerebral Palsy Register. Prevalence per 1000 live births and proportions were analysed using the Cochran-Armitage test for trend. Results: The period covered 368,618 live births and 636 children with CP, making the overall prevalence for the period 1.73 per 1000 live births. This was significantly lower than the prevalence of 1.99 for the previous period 1999–2007 (p = 0.004). The decline in prevalence between the two periods was mainly due to a decrease in children with bilateral spastic and dyskinetic CP born after 37 gestational weeks. The decline in prevalence was accompanied by a smaller proportion of children with associated impairment. Conclusion: We found a decrease in prevalence and severity in CP among Danish children. The decline was most pronounced in children born after 37 gestational weeks with severe subtypes of CP. National guidelines that recommend induction of labour before the completion of week 42 and therapeutic hypothermia for term neonates with hypoxic-ischaemic encephalopathy, may have contributed to the decline.

AB - Aim: To quantify and analyse the prevalence and clinical features of cerebral palsy (CP) in Denmark for birth years 2008–2013 and compare results with previous periods. Method: A nationwide register-based study covering all children with a confirmed diagnosis of CP born in Denmark. Information about CP subtype, aetiology and severity was collected from the Cerebral Palsy Follow-up Program and supplemented from medical files. Data from the Danish Medical Birth Register was included, and the results were compared to previous data from the Danish National Cerebral Palsy Register. Prevalence per 1000 live births and proportions were analysed using the Cochran-Armitage test for trend. Results: The period covered 368,618 live births and 636 children with CP, making the overall prevalence for the period 1.73 per 1000 live births. This was significantly lower than the prevalence of 1.99 for the previous period 1999–2007 (p = 0.004). The decline in prevalence between the two periods was mainly due to a decrease in children with bilateral spastic and dyskinetic CP born after 37 gestational weeks. The decline in prevalence was accompanied by a smaller proportion of children with associated impairment. Conclusion: We found a decrease in prevalence and severity in CP among Danish children. The decline was most pronounced in children born after 37 gestational weeks with severe subtypes of CP. National guidelines that recommend induction of labour before the completion of week 42 and therapeutic hypothermia for term neonates with hypoxic-ischaemic encephalopathy, may have contributed to the decline.

KW - Bilateral spastic cerebral palsy

KW - Cerebral palsy

KW - Denmark

KW - Post-term delivery

KW - Prevalence

KW - Severity

UR - http://www.scopus.com/inward/record.url?scp=85093959264&partnerID=8YFLogxK

U2 - 10.1016/j.ejpn.2020.10.003

DO - 10.1016/j.ejpn.2020.10.003

M3 - Journal article

C2 - 34756357

AN - SCOPUS:85093959264

VL - 30

SP - 155

EP - 161

JO - European Journal of Paediatric Neurology

JF - European Journal of Paediatric Neurology

SN - 1090-3798

ER -

ID: 65857696