Contact With Young Children Increases the Risk of Respiratory Infection in Older Adults in Europe-the RESCEU Study

Koos Korsten; Niels Adriaenssens; Samuel Coenen; Chris C Butler; Jean-Yves Pirçon; Theo J M Verheij; Louis J Bont; Joanne G Wildenbeest; RESCEU Investigators; Thea Kølsen Fischer

doi:10.1093/infdis/jiab519

Contact With Young Children Increases the Risk of Respiratory Infection in Older Adults in Europe-the RESCEU Study

Koos Korsten, Niels Adriaenssens, Samuel Coenen, Chris C Butler, Jean-Yves Pirçon, Theo J M Verheij, Louis J Bont, Joanne G Wildenbeest, RESCEU Investigators , Thea Kølsen Fischer (Member of study group)

5 Citations (Scopus)

Abstract

BACKGROUND: Knowledge about how older adults get a respiratory infection is crucial for planning preventive strategies. We aimed to determine how contact with young children living outside of the household affects the risk of acute respiratory tract infections (ARTI) in community-dwelling older adults.

METHODS: This study is part of the European RESCEU older adult study. Weekly surveillance was performed to detect ARTI throughout 2 winter seasons (2017-2018, 2018-2019). Child exposure, defined as having regular contact with children under 5 living outside of the subject's household, was assessed at baseline. The average attributable fraction was calculated to determine the fraction of ARTI explained by exposure to these children.

RESULTS: We prospectively established that 597/1006 (59%) participants experienced at least 1 ARTI. Child exposure increased the risk of all-cause ARTI (adjusted odds ratio [aOR], 1.58; 95% confidence interval [CI], 1.21 -2.08; P = .001). This risk was highest in those with the most frequent contact (aOR, 1.80; 95% CI, 1.23-2.63; P = .003). The average attributable fraction of child exposure explaining ARTI was 10% (95% CI, 5%-15%).

CONCLUSIONS: One of 10 ARTI in community-dwelling older adults is attributable to exposure to preschool children living outside of the household.

CLINICAL TRIALS REGISTRATION: NCT03621930.

Original language	English
Journal	The Journal of infectious diseases
Volume	226
Issue number	Suppl 1
Pages (from-to)	S79-S86
ISSN	0022-1899
DOIs	https://doi.org/10.1093/infdis/jiab519
Publication status	Published - 12 Aug 2022
Externally published	Yes

Keywords

Aged
Child, Preschool
Europe/epidemiology
Humans
Infant
Odds Ratio
Respiratory Tract Infections/drug therapy
child exposure
elderly
respiratory infection
community

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10.1093/infdis/jiab519

Cite this

Korsten, K., Adriaenssens, N., Coenen, S., Butler, C. C., Pirçon, J.-Y., Verheij, T. J. M., Bont, L. J., Wildenbeest, J. G., RESCEU Investigators , & Fischer, T. K. (2022). Contact With Young Children Increases the Risk of Respiratory Infection in Older Adults in Europe-the RESCEU Study. The Journal of infectious diseases, 226(Suppl 1), S79-S86. https://doi.org/10.1093/infdis/jiab519

Korsten, K, Adriaenssens, N, Coenen, S, Butler, CC, Pirçon, J-Y, Verheij, TJM, Bont, LJ, Wildenbeest, JG, RESCEU Investigators & Fischer, TK 2022, 'Contact With Young Children Increases the Risk of Respiratory Infection in Older Adults in Europe-the RESCEU Study', The Journal of infectious diseases, vol. 226, no. Suppl 1, pp. S79-S86. https://doi.org/10.1093/infdis/jiab519

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title = "Contact With Young Children Increases the Risk of Respiratory Infection in Older Adults in Europe-the RESCEU Study",

abstract = "BACKGROUND: Knowledge about how older adults get a respiratory infection is crucial for planning preventive strategies. We aimed to determine how contact with young children living outside of the household affects the risk of acute respiratory tract infections (ARTI) in community-dwelling older adults.METHODS: This study is part of the European RESCEU older adult study. Weekly surveillance was performed to detect ARTI throughout 2 winter seasons (2017-2018, 2018-2019). Child exposure, defined as having regular contact with children under 5 living outside of the subject's household, was assessed at baseline. The average attributable fraction was calculated to determine the fraction of ARTI explained by exposure to these children.RESULTS: We prospectively established that 597/1006 (59%) participants experienced at least 1 ARTI. Child exposure increased the risk of all-cause ARTI (adjusted odds ratio [aOR], 1.58; 95% confidence interval [CI], 1.21 -2.08; P = .001). This risk was highest in those with the most frequent contact (aOR, 1.80; 95% CI, 1.23-2.63; P = .003). The average attributable fraction of child exposure explaining ARTI was 10% (95% CI, 5%-15%).CONCLUSIONS: One of 10 ARTI in community-dwelling older adults is attributable to exposure to preschool children living outside of the household.CLINICAL TRIALS REGISTRATION: NCT03621930.",

keywords = "Aged, Child, Preschool, Europe/epidemiology, Humans, Infant, Odds Ratio, Respiratory Tract Infections/drug therapy, child exposure, elderly, respiratory infection, community",

author = "Koos Korsten and Niels Adriaenssens and Samuel Coenen and Butler, {Chris C} and Jean-Yves Pir{\c c}on and Verheij, {Theo J M} and Bont, {Louis J} and Wildenbeest, {Joanne G} and {RESCEU Investigators} and Fischer, {Thea K{\o}lsen}",

note = "{\textcopyright} The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America.",

year = "2022",

month = aug,

day = "12",

doi = "10.1093/infdis/jiab519",

language = "English",

volume = "226",

pages = "S79--S86",

journal = "The Journal of infectious diseases",

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T1 - Contact With Young Children Increases the Risk of Respiratory Infection in Older Adults in Europe-the RESCEU Study

AU - Korsten, Koos

AU - Adriaenssens, Niels

AU - Coenen, Samuel

AU - Butler, Chris C

AU - Pirçon, Jean-Yves

AU - Verheij, Theo J M

AU - Bont, Louis J

AU - Wildenbeest, Joanne G

AU - RESCEU Investigators

A2 - Fischer, Thea Kølsen

N1 - © The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America.

PY - 2022/8/12

Y1 - 2022/8/12

N2 - BACKGROUND: Knowledge about how older adults get a respiratory infection is crucial for planning preventive strategies. We aimed to determine how contact with young children living outside of the household affects the risk of acute respiratory tract infections (ARTI) in community-dwelling older adults.METHODS: This study is part of the European RESCEU older adult study. Weekly surveillance was performed to detect ARTI throughout 2 winter seasons (2017-2018, 2018-2019). Child exposure, defined as having regular contact with children under 5 living outside of the subject's household, was assessed at baseline. The average attributable fraction was calculated to determine the fraction of ARTI explained by exposure to these children.RESULTS: We prospectively established that 597/1006 (59%) participants experienced at least 1 ARTI. Child exposure increased the risk of all-cause ARTI (adjusted odds ratio [aOR], 1.58; 95% confidence interval [CI], 1.21 -2.08; P = .001). This risk was highest in those with the most frequent contact (aOR, 1.80; 95% CI, 1.23-2.63; P = .003). The average attributable fraction of child exposure explaining ARTI was 10% (95% CI, 5%-15%).CONCLUSIONS: One of 10 ARTI in community-dwelling older adults is attributable to exposure to preschool children living outside of the household.CLINICAL TRIALS REGISTRATION: NCT03621930.

AB - BACKGROUND: Knowledge about how older adults get a respiratory infection is crucial for planning preventive strategies. We aimed to determine how contact with young children living outside of the household affects the risk of acute respiratory tract infections (ARTI) in community-dwelling older adults.METHODS: This study is part of the European RESCEU older adult study. Weekly surveillance was performed to detect ARTI throughout 2 winter seasons (2017-2018, 2018-2019). Child exposure, defined as having regular contact with children under 5 living outside of the subject's household, was assessed at baseline. The average attributable fraction was calculated to determine the fraction of ARTI explained by exposure to these children.RESULTS: We prospectively established that 597/1006 (59%) participants experienced at least 1 ARTI. Child exposure increased the risk of all-cause ARTI (adjusted odds ratio [aOR], 1.58; 95% confidence interval [CI], 1.21 -2.08; P = .001). This risk was highest in those with the most frequent contact (aOR, 1.80; 95% CI, 1.23-2.63; P = .003). The average attributable fraction of child exposure explaining ARTI was 10% (95% CI, 5%-15%).CONCLUSIONS: One of 10 ARTI in community-dwelling older adults is attributable to exposure to preschool children living outside of the household.CLINICAL TRIALS REGISTRATION: NCT03621930.

KW - Aged

KW - Child, Preschool

KW - Europe/epidemiology

KW - Humans

KW - Infant

KW - Odds Ratio

KW - Respiratory Tract Infections/drug therapy

KW - child exposure

KW - elderly

KW - respiratory infection

KW - community

UR - http://www.scopus.com/inward/record.url?scp=85136341985&partnerID=8YFLogxK

U2 - 10.1093/infdis/jiab519

DO - 10.1093/infdis/jiab519

M3 - Journal article

C2 - 34908153

SN - 0022-1899

VL - 226

SP - S79-S86

JO - The Journal of infectious diseases

JF - The Journal of infectious diseases

IS - Suppl 1

ER -

Contact With Young Children Increases the Risk of Respiratory Infection in Older Adults in Europe-the RESCEU Study

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Keywords

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