Considerable haplotype diversity within the 23kb encompassing the ADH7 gene

Yi Han; Hiroki Oota; Michael V Osier; Andrew J Pakstis; William C Speed; Adekunle Odunsi; Friday Okonofua; Sylvester L B Kajuna; Nganyirwa J Karoma; Selemani Kungulilo; Elena Grigorenko; Olga V Zhukova; Batsheva Bonne-Tamir; Ru-B Lu; Josef Parnas; Leslie O Schulz; Judith R Kidd; Kenneth K Kidd

Considerable haplotype diversity within the 23kb encompassing the ADH7 gene

Yi Han, Hiroki Oota, Michael V Osier, Andrew J Pakstis, William C Speed, Adekunle Odunsi, Friday Okonofua, Sylvester L B Kajuna, Nganyirwa J Karoma, Selemani Kungulilo, Elena Grigorenko, Olga V Zhukova, Batsheva Bonne-Tamir, Ru-B Lu, Josef Parnas, Leslie O Schulz, Judith R Kidd, Kenneth K Kidd

18 Citations (Scopus)

Abstract

Of the seven known human alcohol dehydrogenase (ADH) genes, the non-liver expressed ADH7 gene codes for the enzyme with the highest maximal activity for ethanol. Previous study from our laboratory has suggested that ADH7 has an epistatic role for protection against alcoholism based on a single ADH7 SNP.

Original language	English
Journal	Alcoholism: Clinical and Experimental Research
Volume	29
Issue number	12
Pages (from-to)	2091-100
Number of pages	10
ISSN	0145-6008
Publication status	Published - 2005

Keywords

Alcohol Dehydrogenase
Alcoholism
Alleles
DNA
Ethnic Groups
Gene Frequency
Genotype
Haplotypes
Humans
Linkage Disequilibrium
Polymorphism, Single Nucleotide

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Han, Y., Oota, H., Osier, M. V., Pakstis, A. J., Speed, W. C., Odunsi, A., Okonofua, F., Kajuna, S. L. B., Karoma, N. J., Kungulilo, S., Grigorenko, E., Zhukova, O. V., Bonne-Tamir, B., Lu, R-B., Parnas, J., Schulz, L. O., Kidd, J. R., & Kidd, K. K. (2005). Considerable haplotype diversity within the 23kb encompassing the ADH7 gene. Alcoholism: Clinical and Experimental Research, 29(12), 2091-100. http://gateway.ut.ovid.com/gw1/ovidweb.cgi?WebLinkFrameset=1&S=IDNJHKOANCAGDL00D&returnUrl=http%3a%2f%2fgateway.ut.ovid.com%2fgw1%2fovidweb.cgi%3f%26Full%2bText%3dL%257cS.sh.15.16%257c0%257c00000374-200512000-00002%26S%3dIDNJHKOANCAGDL00D&directlink=http%3a%2f%2fgraphics.ovid.com%2fovftpdfs%2fIDNJHKOANCAGDL00D%2ffs047%2fovft%2flive%2fgv024%2f00000374%2f00000374-200512000-00002

Han, Y, Oota, H, Osier, MV, Pakstis, AJ, Speed, WC, Odunsi, A, Okonofua, F, Kajuna, SLB, Karoma, NJ, Kungulilo, S, Grigorenko, E, Zhukova, OV, Bonne-Tamir, B, Lu, R-B, Parnas, J, Schulz, LO, Kidd, JR & Kidd, KK 2005, 'Considerable haplotype diversity within the 23kb encompassing the ADH7 gene', Alcoholism: Clinical and Experimental Research, vol. 29, no. 12, pp. 2091-100. <http://gateway.ut.ovid.com/gw1/ovidweb.cgi?WebLinkFrameset=1&S=IDNJHKOANCAGDL00D&returnUrl=http%3a%2f%2fgateway.ut.ovid.com%2fgw1%2fovidweb.cgi%3f%26Full%2bText%3dL%257cS.sh.15.16%257c0%257c00000374-200512000-00002%26S%3dIDNJHKOANCAGDL00D&directlink=http%3a%2f%2fgraphics.ovid.com%2fovftpdfs%2fIDNJHKOANCAGDL00D%2ffs047%2fovft%2flive%2fgv024%2f00000374%2f00000374-200512000-00002>

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title = "Considerable haplotype diversity within the 23kb encompassing the ADH7 gene",

abstract = "Of the seven known human alcohol dehydrogenase (ADH) genes, the non-liver expressed ADH7 gene codes for the enzyme with the highest maximal activity for ethanol. Previous study from our laboratory has suggested that ADH7 has an epistatic role for protection against alcoholism based on a single ADH7 SNP.",

keywords = "Alcohol Dehydrogenase, Alcoholism, Alleles, DNA, Ethnic Groups, Gene Frequency, Genotype, Haplotypes, Humans, Linkage Disequilibrium, Polymorphism, Single Nucleotide",

author = "Yi Han and Hiroki Oota and Osier, {Michael V} and Pakstis, {Andrew J} and Speed, {William C} and Adekunle Odunsi and Friday Okonofua and Kajuna, {Sylvester L B} and Karoma, {Nganyirwa J} and Selemani Kungulilo and Elena Grigorenko and Zhukova, {Olga V} and Batsheva Bonne-Tamir and Ru-B Lu and Josef Parnas and Schulz, {Leslie O} and Kidd, {Judith R} and Kidd, {Kenneth K}",

year = "2005",

language = "English",

volume = "29",

pages = "2091--100",

journal = "Alcoholism: Clinical and Experimental Research",

issn = "0145-6008",

publisher = "Wiley-Blackwell Publishing, Inc",

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TY - JOUR

T1 - Considerable haplotype diversity within the 23kb encompassing the ADH7 gene

AU - Han, Yi

AU - Oota, Hiroki

AU - Osier, Michael V

AU - Pakstis, Andrew J

AU - Speed, William C

AU - Odunsi, Adekunle

AU - Okonofua, Friday

AU - Kajuna, Sylvester L B

AU - Karoma, Nganyirwa J

AU - Kungulilo, Selemani

AU - Grigorenko, Elena

AU - Zhukova, Olga V

AU - Bonne-Tamir, Batsheva

AU - Lu, Ru-B

AU - Parnas, Josef

AU - Schulz, Leslie O

AU - Kidd, Judith R

AU - Kidd, Kenneth K

PY - 2005

Y1 - 2005

N2 - Of the seven known human alcohol dehydrogenase (ADH) genes, the non-liver expressed ADH7 gene codes for the enzyme with the highest maximal activity for ethanol. Previous study from our laboratory has suggested that ADH7 has an epistatic role for protection against alcoholism based on a single ADH7 SNP.

AB - Of the seven known human alcohol dehydrogenase (ADH) genes, the non-liver expressed ADH7 gene codes for the enzyme with the highest maximal activity for ethanol. Previous study from our laboratory has suggested that ADH7 has an epistatic role for protection against alcoholism based on a single ADH7 SNP.

KW - Alcohol Dehydrogenase

KW - Alcoholism

KW - Alleles

KW - DNA

KW - Ethnic Groups

KW - Gene Frequency

KW - Genotype

KW - Haplotypes

KW - Humans

KW - Linkage Disequilibrium

KW - Polymorphism, Single Nucleotide

M3 - Journal article

C2 - 16385178

VL - 29

SP - 2091

EP - 2100

JO - Alcoholism: Clinical and Experimental Research

JF - Alcoholism: Clinical and Experimental Research

SN - 0145-6008

IS - 12

ER -

Considerable haplotype diversity within the 23kb encompassing the ADH7 gene

Abstract

Keywords

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