Confirmation of novel type 1 diabetes risk loci in families

J D Cooper; J M M Howson; D Smyth; N M Walker; Hanne Stevens; Jian Yang; J-X She; G S Eisenbarth; M Rewers; J A Todd; B Akolkar; P Concannon; H A Erlich; C Julier; G Morahan; Jørn Nerup; C Nierras; F Pociot; Steve Rich; Type 1 Diabetes Genetics Consortium

doi:10.1007/s00125-012-2450-3

Confirmation of novel type 1 diabetes risk loci in families

J D Cooper, J M M Howson, D Smyth, N M Walker, Hanne Stevens, Jian Yang, J-X She, G S Eisenbarth, M Rewers, J A Todd, B Akolkar, P Concannon, H A Erlich, C Julier, G Morahan, Jørn Nerup, C Nierras, F Pociot, Steve Rich, Type 1 Diabetes Genetics Consortium

51 Citations (Scopus)

Abstract

Over 50 regions of the genome have been associated with type 1 diabetes risk, mainly using large case/control collections. In a recent genome-wide association (GWA) study, 18 novel susceptibility loci were identified and replicated, including replication evidence from 2,319 families. Here, we, the Type 1 Diabetes Genetics Consortium (T1DGC), aimed to exclude the possibility that any of the 18 loci were false-positives due to population stratification by significantly increasing the statistical power of our family study.

Original language	English
Journal	Diabetologia
Volume	55
Issue number	4
Pages (from-to)	996-1000
Number of pages	5
ISSN	0012-186X
DOIs	https://doi.org/10.1007/s00125-012-2450-3
Publication status	Published - Apr 2012

Keywords

Diabetes Mellitus, Type 1
European Continental Ancestry Group
Genetic Loci
Genetic Predisposition to Disease
Genotype
Humans
Polymorphism, Single Nucleotide

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Cooper, J. D., Howson, J. M. M., Smyth, D., Walker, N. M., Stevens, H., Yang, J., She, J.-X., Eisenbarth, G. S., Rewers, M., Todd, J. A., Akolkar, B., Concannon, P., Erlich, H. A., Julier, C., Morahan, G., Nerup, J., Nierras, C., Pociot, F., Rich, S., & Type 1 Diabetes Genetics Consortium (2012). Confirmation of novel type 1 diabetes risk loci in families. Diabetologia, 55(4), 996-1000. https://doi.org/10.1007/s00125-012-2450-3

Cooper, JD, Howson, JMM, Smyth, D, Walker, NM, Stevens, H, Yang, J, She, J-X, Eisenbarth, GS, Rewers, M, Todd, JA, Akolkar, B, Concannon, P, Erlich, HA, Julier, C, Morahan, G, Nerup, J, Nierras, C, Pociot, F, Rich, S & Type 1 Diabetes Genetics Consortium 2012, 'Confirmation of novel type 1 diabetes risk loci in families', Diabetologia, vol. 55, no. 4, pp. 996-1000. https://doi.org/10.1007/s00125-012-2450-3

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abstract = "Over 50 regions of the genome have been associated with type 1 diabetes risk, mainly using large case/control collections. In a recent genome-wide association (GWA) study, 18 novel susceptibility loci were identified and replicated, including replication evidence from 2,319 families. Here, we, the Type 1 Diabetes Genetics Consortium (T1DGC), aimed to exclude the possibility that any of the 18 loci were false-positives due to population stratification by significantly increasing the statistical power of our family study.",

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AU - Howson, J M M

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AU - Yang, Jian

AU - She, J-X

AU - Eisenbarth, G S

AU - Rewers, M

AU - Todd, J A

AU - Akolkar, B

AU - Concannon, P

AU - Erlich, H A

AU - Julier, C

AU - Morahan, G

AU - Nerup, Jørn

AU - Nierras, C

AU - Pociot, F

AU - Rich, Steve

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KW - European Continental Ancestry Group

KW - Genetic Loci

KW - Genetic Predisposition to Disease

KW - Genotype

KW - Humans

KW - Polymorphism, Single Nucleotide

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Confirmation of novel type 1 diabetes risk loci in families

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Keywords

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