Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Concomitant occurrence of EGFR (epidermal growth factor receptor) and KRAS (V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog) mutations in an ALK (anaplastic lymphoma kinase)-positive lung adenocarcinoma patient with acquired resistance to crizotinib: a case report

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. An update on head and neck cancer: new entities and their histopathology, molecular background, treatment, and outcome

    Research output: Contribution to journalReviewResearchpeer-review

  2. Very Early Response Evaluation by PET/MR in Patients with Lung Cancer-Timing and Feasibility

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Application of cell-free DNA for genomic tumor profiling: a feasibility study

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations
Anaplastic lymphoma kinase-positive non-small cell lung carcinoma patients are generally highly responsive to the dual anaplastic lymphoma kinase and MET tyrosine kinase inhibitor crizotinib. However, they eventually acquire resistance to this drug, preventing the anaplastic lymphoma kinase inhibitors from having a prolonged beneficial effect. The molecular mechanisms responsible for crizotinib resistance are beginning to emerge, e.g., in some anaplastic lymphoma kinase-positive non-small cell lung carcinomas the development of secondary mutations in this gene has been described. However, the events behind crizotinib-resistance currently remain largely uncharacterized. Thus, we report on an anaplastic lymphoma kinase-positive non-small cell lung carcinoma patient with concomitant occurrence of epidermal growth factor receptor and V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog mutations upon development of crizotinib-resistance.
Original languageEnglish
JournalBMC Research Notes
Volume6
Issue number1
Pages (from-to)489
ISSN1756-0500
DOIs
Publication statusPublished - 2013

ID: 42237170