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Concentrations of the acute phase reactants high-sensitive C-reactive protein and YKL-40 and of interleukin-6 before and after treatment in patients with acromegaly and growth hormone deficiency

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BACKGROUND: Acromegaly is accompanied by increased cardiovascular mortality and a cluster of proatherogenic risk factors. In the general population, ischaemic heart disease (IHD) is associated with elevated levels of inflammatory markers. The acute phase reactant (APR) C-reactive protein (CRP) has been reported to be reduced in acromegaly and increase after treatment, suggesting that excess of GH/IGF-I could have anti-inflammatory effects. This is in accordance with results obtained in patients with growth hormone deficiency (GHD), where increased levels of CRP have been reported.

OBJECTIVE: To investigate the hypothesis that the GH/IGF-I system is a suppressive regulator of inflammatory processes.

SUBJECTS AND METHODS: Twenty-one acromegalic patients and 19 GH-deficient patients were studied. The two APRs CRP and YKL-40 and the proinflammatory cytokine interleukin-6 (IL-6) were measured before and after treatment and in healthy matched controls.

RESULTS: In acromegalic patients, serum concentrations of high-sensitive CRP (hsCRP) and YKL-40 were reduced compared to controls (P < 0.001) and increased (P < 0.001) after treatment, together with IL-6 (P = 0.021), to levels comparable with controls. Pretreatment serum YKL-40 and IL-6 showed a significant inverse correlation with IGF-I and GH. In GH-deficient patients, hsCRP and YKL-40 were elevated compared to controls (P = 0.001 and P = 0.048). During treatment, levels of both APRs showed a trend towards a decrease (P = 0.087 and P = 0.060), and after treatment, levels of YKL-40 no longer differed from that of controls. Serum IL-6 was not different from controls and did not change during GH treatment.

CONCLUSION: The results point to the possibility of a relationship between GH disturbances and inflammatory processes.

Original languageEnglish
JournalClinical Endocrinology
Volume67
Issue number6
Pages (from-to)909-16
Number of pages8
ISSN0300-0664
DOIs
Publication statusPublished - Dec 2007

    Research areas

  • Acromegaly, Adipokines, Adolescent, Adult, C-Reactive Protein, Case-Control Studies, Chitinase-3-Like Protein 1, Dwarfism, Pituitary, Female, Human Growth Hormone, Humans, Insulin-Like Growth Factor I, Interleukin-6, Lectins, Male, Middle Aged, Young Adult, Journal Article

ID: 52683637