BACKGROUND: Acromegaly is accompanied by increased cardiovascular mortality and a cluster of proatherogenic risk factors. In the general population, ischaemic heart disease (IHD) is associated with elevated levels of inflammatory markers. The acute phase reactant (APR) C-reactive protein (CRP) has been reported to be reduced in acromegaly and increase after treatment, suggesting that excess of GH/IGF-I could have anti-inflammatory effects. This is in accordance with results obtained in patients with growth hormone deficiency (GHD), where increased levels of CRP have been reported.
OBJECTIVE: To investigate the hypothesis that the GH/IGF-I system is a suppressive regulator of inflammatory processes.
SUBJECTS AND METHODS: Twenty-one acromegalic patients and 19 GH-deficient patients were studied. The two APRs CRP and YKL-40 and the proinflammatory cytokine interleukin-6 (IL-6) were measured before and after treatment and in healthy matched controls.
RESULTS: In acromegalic patients, serum concentrations of high-sensitive CRP (hsCRP) and YKL-40 were reduced compared to controls (P < 0.001) and increased (P < 0.001) after treatment, together with IL-6 (P = 0.021), to levels comparable with controls. Pretreatment serum YKL-40 and IL-6 showed a significant inverse correlation with IGF-I and GH. In GH-deficient patients, hsCRP and YKL-40 were elevated compared to controls (P = 0.001 and P = 0.048). During treatment, levels of both APRs showed a trend towards a decrease (P = 0.087 and P = 0.060), and after treatment, levels of YKL-40 no longer differed from that of controls. Serum IL-6 was not different from controls and did not change during GH treatment.
CONCLUSION: The results point to the possibility of a relationship between GH disturbances and inflammatory processes.
|Number of pages||8|
|Publication status||Published - Dec 2007|
- C-Reactive Protein
- Case-Control Studies
- Chitinase-3-Like Protein 1
- Dwarfism, Pituitary
- Human Growth Hormone
- Insulin-Like Growth Factor I
- Middle Aged
- Young Adult
- Journal Article