Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Concentration of soluble urokinase plasminogen activator receptor (suPAR) in the pre-ovulatory follicular fluid is associated with development of ovarian hyperstimulation syndrome during ovarian stimulation

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Gonadotropin receptor variants are linked to cumulative live birth rate after in vitro fertilization

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Cryopreservation of ovarian tissue may be considered in young girls with galactosemia

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Effect of GnRHa ovulation trigger dose on follicular fluid characteristics and granulosa cell gene expression profiles

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Propagation of Spermatogonial Stem Cell-Like Cells From Infant Boys

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Associations of different molecular forms of antimüllerian hormone and biomarkers of polycystic ovary syndrome and normal women

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Genome-wide gene expression in a pharmacological hormonal transition model and its relation to depressive symptoms

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. The clinical use of Anti-Müllerian Hormone in female reproduction.

    Research output: Book/ReportPh.D. thesisResearch

View graph of relations

PURPOSE: Investigating whether pre-ovulatory follicular fluid (FF) levels of selected proteins differ between women who do or do not develop severe ovarian hyperstimulation syndrome (OHSS) and evaluate whether they potentially could guide a "freeze-all" strategy.

METHODS: FF was collected during a randomized controlled trial comparing OHSS in antagonist versus agonist protocol including 1050 women in their first assisted reproductive technology (ART) cycle during year 2009-2013. The present sub-study is a matched case-control study comparing FF levels of soluble urokinase plasminogen activator receptor (suPAR), C-reactive protein, placental growth factor, vascular endothelial growth factor, and angiopoietins 1 and 2 in OHSS cases (n = 25, severe OHSS, and ≥ 15 oocytes), high-risk controls (n = 25, no OHSS, and ≥ 15 oocytes), and low-risk controls (n = 25, no OHSS, and 5-8 oocytes).

RESULTS: FF level of suPAR differed significantly between the three groups (p = 0.018) with mean (SD) levels of 2.3 (0.4) μg/L, 2.6 (0.8) μg/L, and 2.8 (0.6) μg/L in OHSS cases, high-risk controls, and low-risk controls, respectively. Receiver operating characteristic curve analysis demonstrated that suPAR levels could predict severe OHSS (AUC 0.678; 95% CI 0.553-0.803) with a sensitivity of 64% and a specificity of 66%. None of the other investigated proteins differed between the three groups or between OHSS cases and combined controls.

CONCLUSION: The pre-ovulatory FF level of suPAR was significantly lower in women developing severe OHSS, indicating that the plasminogen activator system could be involved in the pathophysiology of OHSS. However, suPAR did not provide a satisfying predictive value for the prediction of OHSS.

Original languageEnglish
JournalJournal of Assisted Reproduction and Genetics
Volume35
Issue number12
Pages (from-to)2187-2193
ISSN1058-0468
DOIs
Publication statusPublished - Dec 2018

ID: 55337988