Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Completeness of RET testing in patients with medullary thyroid carcinoma in Denmark 1997-2013: a nationwide study

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. The Danish in-hospital cardiac arrest registry (DANARREST)

    Research output: Contribution to journalReviewResearchpeer-review

  2. The positive predictive value of spontaneous subarachnoid hemorrhage diagnoses in the Danish National Patient Register

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Incidence and prevalence of multiple endocrine neoplasia 2A in Denmark 1901-2014: a nationwide study

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Shared heritability and functional enrichment across six solid cancers

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Hippocampal volume, cognitive functions, depression, anxiety, and quality of life in patients with Cushing's syndrome

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Thyroid Peroxidase Antibodies and Prospective Live Birth Rate: A Cohort Study of Women with Recurrent Pregnancy Loss

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Age-related renal function decline in Fabry disease patients on enzyme replacement therapy: a longitudinal cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Kinetics of the soluble urokinase plasminogen activator receptor (suPAR) in cirrhosis

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Danish Thyroid Cancer Group (DATHYRCA)
View graph of relations

Background: The completeness of REarranged during Transfection (RET) testing in patients with medullary thyroid carcinoma (MTC) was recently reported as 60%. However, the completeness on a population level is unknown. Similarly, it is unknown if the first Danish guidelines from 2002, recommending RET testing in all MTC patients, improved completeness in Denmark. We conducted a nationwide retrospective cohort study aiming to evaluate the completeness of RET testing in the Danish MTC cohort. Additionally, we aimed to assess the completeness before and after publication of the first Danish guidelines and characterize MTC patients who had not been tested.

Methods: The study included 200 patients identified from the nationwide Danish MTC cohort 1997-2013. To identify RET tested MTC patients before December 31, 2014, the MTC cohort was cross-checked with the nationwide Danish RET cohort 1994-2014. To characterize MTC patients who had not been RET tested, we reviewed their medical records and compared them with MTC patients who had been tested.

Results: Completeness of RET testing in the overall MTC cohort was 87% (95% CI: 0.81-0.91; 173/200). In the adjusted MTC cohort, after excluding patients diagnosed with hereditary MTC by screening, completeness was 83% (95% CI: 0.76-0.88; 131/158). Completeness was 88% (95% CI: 0.75-0.95; 42/48) and 81% (95% CI: 0.72-0.88) (89/110) before and after publication of the first Danish guidelines, respectively. Patients not RET tested had a higher median age at diagnosis compared to those RET tested. Median time to death was shorter in those not tested relative to those tested.

Conclusion: The completeness of RET testing in MTC patients in Denmark seems to be higher than reported in other cohorts. No improvement in completeness was detected after publication of the first Danish guidelines. In addition, data indicate that advanced age and low life expectancy at MTC diagnosis may serve as prognostic indicators to identify patients having a higher likelihood of missing the compulsory RET test.

Original languageEnglish
JournalClinical Epidemiology
Volume11
Pages (from-to)93-99
Number of pages7
ISSN1179-1349
DOIs
Publication statusPublished - 2019

ID: 57283871