Comparison of two sulfonylureas with high and low myocardial K(ATP) channel affinity on myocardial infarct size and metabolism in a rat model of type 2 diabetes

Steen Buus Kristiansen; B Løfgren; J.M. Nielsen; N B Støttrup; Esben Selmer Buhl; J E Nielsen-Kudsk; Torsten Toftegård Nielsen; Jørgen Rungby; A Flyvbjerg

doi:10.1007/s00125-010-1970-y

Comparison of two sulfonylureas with high and low myocardial K(ATP) channel affinity on myocardial infarct size and metabolism in a rat model of type 2 diabetes

Steen Buus Kristiansen, B Løfgren, J.M. Nielsen, N B Støttrup, Esben Selmer Buhl, J E Nielsen-Kudsk, Torsten Toftegård Nielsen, Jørgen Rungby, A Flyvbjerg

26 Citations (Scopus)

Abstract

AIMS/HYPOTHESIS: Sulfonylureas (SUs) may impair outcome in patients with acute coronary syndrome. Most experimental studies of the myocardial effects of SU treatment are performed in non-diabetic models. We compared the effect of two widely used SUs, glibenclamide (gb) and gliclazide (gc), with high and low myocardial K(ATP) channel affinity, respectively, at therapeutic concentrations on infarct size, left ventricular (LV) function and myocardial glycogen, lactate and alanine content before and after ischaemia/reperfusion (I/R). METHODS: Non-diabetic Wistar and diabetic Goto-Kakizaki rat hearts were investigated in a Langendorff preparation. Gb (0.1 μmol/l) and gc (1.0 μmol/l) were administrated throughout the study. Infarct size was evaluated after 120 min of reperfusion. Myocardial metabolite content was measured before and after ischaemia. RESULTS: Infarct size was smaller in diabetic hearts than in non-diabetic hearts (0.33 ± 0.03 vs 0.51 ± 0.05, p

Original language	English
Journal	Diabetologia
Volume	54
Issue number	2
Pages (from-to)	451-458
Number of pages	8
ISSN	0012-186X
DOIs	https://doi.org/10.1007/s00125-010-1970-y
Publication status	Published - 2011

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Kristiansen, S. B., Løfgren, B., Nielsen, J. M., Støttrup, N. B., Buhl, E. S., Nielsen-Kudsk, J. E., Nielsen, T. T., Rungby, J., & Flyvbjerg, A. (2011). Comparison of two sulfonylureas with high and low myocardial K(ATP) channel affinity on myocardial infarct size and metabolism in a rat model of type 2 diabetes. Diabetologia, 54(2), 451-458. https://doi.org/10.1007/s00125-010-1970-y

Kristiansen, SB, Løfgren, B, Nielsen, JM, Støttrup, NB, Buhl, ES, Nielsen-Kudsk, JE, Nielsen, TT, Rungby, J & Flyvbjerg, A 2011, 'Comparison of two sulfonylureas with high and low myocardial K(ATP) channel affinity on myocardial infarct size and metabolism in a rat model of type 2 diabetes', Diabetologia, vol. 54, no. 2, pp. 451-458. https://doi.org/10.1007/s00125-010-1970-y

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title = "Comparison of two sulfonylureas with high and low myocardial K(ATP) channel affinity on myocardial infarct size and metabolism in a rat model of type 2 diabetes",

abstract = "AIMS/HYPOTHESIS: Sulfonylureas (SUs) may impair outcome in patients with acute coronary syndrome. Most experimental studies of the myocardial effects of SU treatment are performed in non-diabetic models. We compared the effect of two widely used SUs, glibenclamide (gb) and gliclazide (gc), with high and low myocardial K(ATP) channel affinity, respectively, at therapeutic concentrations on infarct size, left ventricular (LV) function and myocardial glycogen, lactate and alanine content before and after ischaemia/reperfusion (I/R). METHODS: Non-diabetic Wistar and diabetic Goto-Kakizaki rat hearts were investigated in a Langendorff preparation. Gb (0.1 μmol/l) and gc (1.0 μmol/l) were administrated throughout the study. Infarct size was evaluated after 120 min of reperfusion. Myocardial metabolite content was measured before and after ischaemia. RESULTS: Infarct size was smaller in diabetic hearts than in non-diabetic hearts (0.33 ± 0.03 vs 0.51 ± 0.05, p ",

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doi = "10.1007/s00125-010-1970-y",

language = "English",

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T1 - Comparison of two sulfonylureas with high and low myocardial K(ATP) channel affinity on myocardial infarct size and metabolism in a rat model of type 2 diabetes

AU - Kristiansen, Steen Buus

AU - Løfgren, B

AU - Nielsen, J.M.

AU - Støttrup, N B

AU - Buhl, Esben Selmer

AU - Nielsen-Kudsk, J E

AU - Nielsen, Torsten Toftegård

AU - Rungby, Jørgen

AU - Flyvbjerg, A

PY - 2011

Y1 - 2011

N2 - AIMS/HYPOTHESIS: Sulfonylureas (SUs) may impair outcome in patients with acute coronary syndrome. Most experimental studies of the myocardial effects of SU treatment are performed in non-diabetic models. We compared the effect of two widely used SUs, glibenclamide (gb) and gliclazide (gc), with high and low myocardial K(ATP) channel affinity, respectively, at therapeutic concentrations on infarct size, left ventricular (LV) function and myocardial glycogen, lactate and alanine content before and after ischaemia/reperfusion (I/R). METHODS: Non-diabetic Wistar and diabetic Goto-Kakizaki rat hearts were investigated in a Langendorff preparation. Gb (0.1 μmol/l) and gc (1.0 μmol/l) were administrated throughout the study. Infarct size was evaluated after 120 min of reperfusion. Myocardial metabolite content was measured before and after ischaemia. RESULTS: Infarct size was smaller in diabetic hearts than in non-diabetic hearts (0.33 ± 0.03 vs 0.51 ± 0.05, p

AB - AIMS/HYPOTHESIS: Sulfonylureas (SUs) may impair outcome in patients with acute coronary syndrome. Most experimental studies of the myocardial effects of SU treatment are performed in non-diabetic models. We compared the effect of two widely used SUs, glibenclamide (gb) and gliclazide (gc), with high and low myocardial K(ATP) channel affinity, respectively, at therapeutic concentrations on infarct size, left ventricular (LV) function and myocardial glycogen, lactate and alanine content before and after ischaemia/reperfusion (I/R). METHODS: Non-diabetic Wistar and diabetic Goto-Kakizaki rat hearts were investigated in a Langendorff preparation. Gb (0.1 μmol/l) and gc (1.0 μmol/l) were administrated throughout the study. Infarct size was evaluated after 120 min of reperfusion. Myocardial metabolite content was measured before and after ischaemia. RESULTS: Infarct size was smaller in diabetic hearts than in non-diabetic hearts (0.33 ± 0.03 vs 0.51 ± 0.05, p

UR - https://www.scopus.com/pages/publications/78951475818

U2 - 10.1007/s00125-010-1970-y

DO - 10.1007/s00125-010-1970-y

M3 - Journal article

SN - 0012-186X

VL - 54

SP - 451

EP - 458

JO - Diabetologia

JF - Diabetologia

IS - 2

ER -

Comparison of two sulfonylureas with high and low myocardial K(ATP) channel affinity on myocardial infarct size and metabolism in a rat model of type 2 diabetes

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