Comparison of Translocator Protein Expression Between Tumefactive Multiple Sclerosis and Glioblastoma

Per Jensen; Morten Blinkenberg; Lars Hageman Pinborg

doi:10.1097/RLU.0000000000004739

Comparison of Translocator Protein Expression Between Tumefactive Multiple Sclerosis and Glioblastoma

Per Jensen, Morten Blinkenberg, Lars Hageman Pinborg^*

^*Corresponding author for this work

Neurology, Department of

Abstract

This figure presents a comparison of molecular imaging of the translocator protein (TSPO) and contrast-enhanced MRI in 2 patients with tumefactive multiple sclerosis and glioblastoma, respectively. In the case of the tumefactive multiple sclerosis patient, TSPO uptake is primarily located centrally, while in the glioblastoma patient, TSPO uptake is predominantly situated peripherally to the central necrotic area. These findings suggest that TSPO imaging could be a noninvasive imaging technique for distinguishing between these 2 diagnoses.

Original language	English
Journal	Clinical Nuclear Medicine
Volume	48
Issue number	8
Pages (from-to)	e403-e404
ISSN	0363-9762
DOIs	https://doi.org/10.1097/RLU.0000000000004739
Publication status	Published - 1 Aug 2023

Keywords

Glioblastoma/diagnostic imaging
Humans
Multiple Sclerosis/diagnostic imaging
Positron-Emission Tomography/methods
Protein Transport
Receptors, GABA/metabolism
tumefactive MS
translocator protein
MRI
glioma
SPECT

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10.1097/RLU.0000000000004739

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title = "Comparison of Translocator Protein Expression Between Tumefactive Multiple Sclerosis and Glioblastoma",

abstract = "This figure presents a comparison of molecular imaging of the translocator protein (TSPO) and contrast-enhanced MRI in 2 patients with tumefactive multiple sclerosis and glioblastoma, respectively. In the case of the tumefactive multiple sclerosis patient, TSPO uptake is primarily located centrally, while in the glioblastoma patient, TSPO uptake is predominantly situated peripherally to the central necrotic area. These findings suggest that TSPO imaging could be a noninvasive imaging technique for distinguishing between these 2 diagnoses.",

keywords = "Glioblastoma/diagnostic imaging, Humans, Multiple Sclerosis/diagnostic imaging, Positron-Emission Tomography/methods, Protein Transport, Receptors, GABA/metabolism, tumefactive MS, translocator protein, MRI, glioma, SPECT",

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AU - Jensen, Per

AU - Blinkenberg, Morten

AU - Pinborg, Lars Hageman

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Y1 - 2023/8/1

N2 - This figure presents a comparison of molecular imaging of the translocator protein (TSPO) and contrast-enhanced MRI in 2 patients with tumefactive multiple sclerosis and glioblastoma, respectively. In the case of the tumefactive multiple sclerosis patient, TSPO uptake is primarily located centrally, while in the glioblastoma patient, TSPO uptake is predominantly situated peripherally to the central necrotic area. These findings suggest that TSPO imaging could be a noninvasive imaging technique for distinguishing between these 2 diagnoses.

AB - This figure presents a comparison of molecular imaging of the translocator protein (TSPO) and contrast-enhanced MRI in 2 patients with tumefactive multiple sclerosis and glioblastoma, respectively. In the case of the tumefactive multiple sclerosis patient, TSPO uptake is primarily located centrally, while in the glioblastoma patient, TSPO uptake is predominantly situated peripherally to the central necrotic area. These findings suggest that TSPO imaging could be a noninvasive imaging technique for distinguishing between these 2 diagnoses.

KW - Glioblastoma/diagnostic imaging

KW - Humans

KW - Multiple Sclerosis/diagnostic imaging

KW - Positron-Emission Tomography/methods

KW - Protein Transport

KW - Receptors, GABA/metabolism

KW - tumefactive MS

KW - translocator protein

KW - MRI

KW - glioma

KW - SPECT

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DO - 10.1097/RLU.0000000000004739

M3 - Journal article

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VL - 48

SP - e403-e404

JO - Clinical Nuclear Medicine

JF - Clinical Nuclear Medicine

SN - 0363-9762

IS - 8

ER -

Comparison of Translocator Protein Expression Between Tumefactive Multiple Sclerosis and Glioblastoma

Abstract

Keywords

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