Comparison of therapeutic efficacy and biodistribution of 213Bi- and 211At-labeled monoclonal antibody MX35 in an ovarian cancer model

Anna M E Gustafsson; Tom Bäck; Jörgen Elgqvist; Lars Jacobsson; Ragnar Hultborn; Per Albertsson; Alfred Morgenstern; Frank Bruchertseifer; Holger Jensen; Sture Lindegren

doi:10.1016/j.nucmedbio.2011.07.003

Comparison of therapeutic efficacy and biodistribution of 213Bi- and 211At-labeled monoclonal antibody MX35 in an ovarian cancer model

Anna M E Gustafsson, Tom Bäck, Jörgen Elgqvist, Lars Jacobsson, Ragnar Hultborn, Per Albertsson, Alfred Morgenstern, Frank Bruchertseifer, Holger Jensen, Sture Lindegren

Department of Clinical Physiology, Nuclear Medicine & PET

34 Citations (Scopus)

Abstract

The purpose of this study was to compare the therapeutic efficacy and biodistribution of the monoclonal antibody MX35 labeled with either (213)Bi or (211)At, both α-emitters, in an ovarian cancer model.

Original language	English
Journal	Nuclear Medicine and Biology
Volume	39
Issue number	1
Pages (from-to)	15-22
Number of pages	8
ISSN	0969-8051
DOIs	https://doi.org/10.1016/j.nucmedbio.2011.07.003
Publication status	Published - 2012

Keywords

Alpha Particles
Animals
Antibodies, Monoclonal
Female
Mice
Mice, Inbred BALB C
Mice, Nude
Neoplasms, Experimental
Organometallic Compounds
Ovarian Neoplasms
Radioisotopes
Tissue Distribution
Treatment Outcome

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Gustafsson, A. M. E., Bäck, T., Elgqvist, J., Jacobsson, L., Hultborn, R., Albertsson, P., Morgenstern, A., Bruchertseifer, F., Jensen, H., & Lindegren, S. (2012). Comparison of therapeutic efficacy and biodistribution of 213Bi- and 211At-labeled monoclonal antibody MX35 in an ovarian cancer model. Nuclear Medicine and Biology, 39(1), 15-22. https://doi.org/10.1016/j.nucmedbio.2011.07.003

Gustafsson, AME, Bäck, T, Elgqvist, J, Jacobsson, L, Hultborn, R, Albertsson, P, Morgenstern, A, Bruchertseifer, F, Jensen, H & Lindegren, S 2012, 'Comparison of therapeutic efficacy and biodistribution of 213Bi- and 211At-labeled monoclonal antibody MX35 in an ovarian cancer model', Nuclear Medicine and Biology, vol. 39, no. 1, pp. 15-22. https://doi.org/10.1016/j.nucmedbio.2011.07.003

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AU - Gustafsson, Anna M E

AU - Bäck, Tom

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AU - Jacobsson, Lars

AU - Hultborn, Ragnar

AU - Albertsson, Per

AU - Morgenstern, Alfred

AU - Bruchertseifer, Frank

AU - Jensen, Holger

AU - Lindegren, Sture

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KW - Antibodies, Monoclonal

KW - Female

KW - Mice

KW - Mice, Inbred BALB C

KW - Mice, Nude

KW - Neoplasms, Experimental

KW - Organometallic Compounds

KW - Ovarian Neoplasms

KW - Radioisotopes

KW - Tissue Distribution

KW - Treatment Outcome

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Comparison of therapeutic efficacy and biodistribution of 213Bi- and 211At-labeled monoclonal antibody MX35 in an ovarian cancer model

Abstract

Keywords

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