Comparison of PSA density and lesion volume strategies for selecting men with equivocal PI-RADS 3 lesions on bpMRI for biopsies

Karen-Cecilie Kortenbach; Vibeke Løgager; Henrik S Thomsen; Lars Boesen

doi:10.1007/s00261-022-03720-0

Comparison of PSA density and lesion volume strategies for selecting men with equivocal PI-RADS 3 lesions on bpMRI for biopsies

Karen-Cecilie Kortenbach^*, Vibeke Løgager, Henrik S Thomsen, Lars Boesen

^*Corresponding author for this work

3 Citations (Scopus)

Abstract

PURPOSE: To compare two strategies: Prostate-specific antigen density (PSAd) and lesion volume measurement in ruling out significant prostate cancer (sPCa) in men with equivocal Prostate Imaging Reporting and Data System (PI-RADS) category 3 index lesions on biparametric magnetic resonance imaging.

METHODS: In total, 130 men from our database had index lesions with PI-RADS scores of 3. Prostate volume was measured using the ellipsoid method, in accordance with PI-RADS version 2.1 criteria. Index lesion volumes were also measured using the ellipsoidal formula on the diffusion-weighted imaging sequence with the highest b-value and sagittal T2 sequences.

RESULTS: Among 130 men with PI-RADS category 3 index lesions, 23 (18%) had sPCa. In total, 6 of the 89 men with PSAd < 0.15 ng/mL2 (7%) had sPCa, whereas 8 of the 49 men with index lesion volumes < 0.5 mL (16%) had sPCa. The difference was statistically significant (McNemar, p < 0.0001).

CONCLUSION: The PSAd strategy performed better than the lesion volume strategy in ruling out sPCa in men with equivocal PI-RADS category 3 index lesions.

Original language	English
Journal	Abdominal radiology (New York)
Volume	48
Issue number	2
Pages (from-to)	688-693
Number of pages	6
ISSN	2366-004X
DOIs	https://doi.org/10.1007/s00261-022-03720-0
Publication status	Published - Feb 2023

Keywords

Diffusion Magnetic Resonance Imaging
Humans
Image-Guided Biopsy/methods
Magnetic Resonance Imaging/methods
Male
Prostate-Specific Antigen
Prostatic Neoplasms/diagnostic imaging
Retrospective Studies

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10.1007/s00261-022-03720-0Licence: CC BY

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@article{44238b06dc0e4cffa887609257b475ec,

title = "Comparison of PSA density and lesion volume strategies for selecting men with equivocal PI-RADS 3 lesions on bpMRI for biopsies",

abstract = "PURPOSE: To compare two strategies: Prostate-specific antigen density (PSAd) and lesion volume measurement in ruling out significant prostate cancer (sPCa) in men with equivocal Prostate Imaging Reporting and Data System (PI-RADS) category 3 index lesions on biparametric magnetic resonance imaging.METHODS: In total, 130 men from our database had index lesions with PI-RADS scores of 3. Prostate volume was measured using the ellipsoid method, in accordance with PI-RADS version 2.1 criteria. Index lesion volumes were also measured using the ellipsoidal formula on the diffusion-weighted imaging sequence with the highest b-value and sagittal T2 sequences.RESULTS: Among 130 men with PI-RADS category 3 index lesions, 23 (18%) had sPCa. In total, 6 of the 89 men with PSAd < 0.15 ng/mL2 (7%) had sPCa, whereas 8 of the 49 men with index lesion volumes < 0.5 mL (16%) had sPCa. The difference was statistically significant (McNemar, p < 0.0001).CONCLUSION: The PSAd strategy performed better than the lesion volume strategy in ruling out sPCa in men with equivocal PI-RADS category 3 index lesions.",

keywords = "Diffusion Magnetic Resonance Imaging, Humans, Image-Guided Biopsy/methods, Magnetic Resonance Imaging/methods, Male, Prostate-Specific Antigen, Prostatic Neoplasms/diagnostic imaging, Retrospective Studies",

author = "Karen-Cecilie Kortenbach and Vibeke L{\o}gager and Thomsen, {Henrik S} and Lars Boesen",

note = "{\textcopyright} 2022. The Author(s).",

year = "2023",

month = feb,

doi = "10.1007/s00261-022-03720-0",

language = "English",

volume = "48",

pages = "688--693",

journal = "Abdominal radiology (New York)",

issn = "2366-004X",

publisher = "Springer",

number = "2",

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T1 - Comparison of PSA density and lesion volume strategies for selecting men with equivocal PI-RADS 3 lesions on bpMRI for biopsies

AU - Kortenbach, Karen-Cecilie

AU - Løgager, Vibeke

AU - Thomsen, Henrik S

AU - Boesen, Lars

PY - 2023/2

Y1 - 2023/2

N2 - PURPOSE: To compare two strategies: Prostate-specific antigen density (PSAd) and lesion volume measurement in ruling out significant prostate cancer (sPCa) in men with equivocal Prostate Imaging Reporting and Data System (PI-RADS) category 3 index lesions on biparametric magnetic resonance imaging.METHODS: In total, 130 men from our database had index lesions with PI-RADS scores of 3. Prostate volume was measured using the ellipsoid method, in accordance with PI-RADS version 2.1 criteria. Index lesion volumes were also measured using the ellipsoidal formula on the diffusion-weighted imaging sequence with the highest b-value and sagittal T2 sequences.RESULTS: Among 130 men with PI-RADS category 3 index lesions, 23 (18%) had sPCa. In total, 6 of the 89 men with PSAd < 0.15 ng/mL2 (7%) had sPCa, whereas 8 of the 49 men with index lesion volumes < 0.5 mL (16%) had sPCa. The difference was statistically significant (McNemar, p < 0.0001).CONCLUSION: The PSAd strategy performed better than the lesion volume strategy in ruling out sPCa in men with equivocal PI-RADS category 3 index lesions.

AB - PURPOSE: To compare two strategies: Prostate-specific antigen density (PSAd) and lesion volume measurement in ruling out significant prostate cancer (sPCa) in men with equivocal Prostate Imaging Reporting and Data System (PI-RADS) category 3 index lesions on biparametric magnetic resonance imaging.METHODS: In total, 130 men from our database had index lesions with PI-RADS scores of 3. Prostate volume was measured using the ellipsoid method, in accordance with PI-RADS version 2.1 criteria. Index lesion volumes were also measured using the ellipsoidal formula on the diffusion-weighted imaging sequence with the highest b-value and sagittal T2 sequences.RESULTS: Among 130 men with PI-RADS category 3 index lesions, 23 (18%) had sPCa. In total, 6 of the 89 men with PSAd < 0.15 ng/mL2 (7%) had sPCa, whereas 8 of the 49 men with index lesion volumes < 0.5 mL (16%) had sPCa. The difference was statistically significant (McNemar, p < 0.0001).CONCLUSION: The PSAd strategy performed better than the lesion volume strategy in ruling out sPCa in men with equivocal PI-RADS category 3 index lesions.

KW - Diffusion Magnetic Resonance Imaging

KW - Humans

KW - Image-Guided Biopsy/methods

KW - Magnetic Resonance Imaging/methods

KW - Male

KW - Prostate-Specific Antigen

KW - Prostatic Neoplasms/diagnostic imaging

KW - Retrospective Studies

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DO - 10.1007/s00261-022-03720-0

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C2 - 36318331

SN - 2366-004X

VL - 48

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EP - 693

JO - Abdominal radiology (New York)

JF - Abdominal radiology (New York)

IS - 2

ER -

Comparison of PSA density and lesion volume strategies for selecting men with equivocal PI-RADS 3 lesions on bpMRI for biopsies

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