Comparison of near-infrared oximeters in a liquid optical phantom with varying intralipid and blood content

S. Kleiserstefan; S. Hyttel-Sorensen; G. Greisen; M. Wolf

doi:10.1007/978-1-4939-3023-4_52

Comparison of near-infrared oximeters in a liquid optical phantom with varying intralipid and blood content

S. Kleiserstefan^*, S. Hyttel-Sorensen, G. Greisen, M. Wolf

^*Corresponding author for this work

Department of Neonatology

14 Citations (Scopus)

Abstract

The interpretation of cerebral tissue oxygen saturation values (StO₂) in clinical settings is currently complicated by the use of different near-infrared spectrophotometry (NIRS) devices producing different StO2 values for the same oxygenation due to differences in the algorithms and technical aspects. The aim was to investigate the effect of changes in scattering and absorption on the StO₂ of different NIRS devices in a liquid optical phantom. We compared three continuous-wave (CW) with a frequency domain (FD) NIRS device. Responsiveness to oxygenation changes was only slightly altered by different intralipid (IL) concentrations. However, alterations in haematocrit (htc) showed a strong effect: increased htc led to a 20–35%increased response of allCWdevices compared to the FD device, probably due to differences in algorithms regarding the water concentration.

Original language	English
Title of host publication	Oxygen Transport to Tissue XXXVII
Editors	Clare E. Elwell, Terence S. Leung, David K. Harrison
Number of pages	6
Publisher	Springer New York LLC
Publication date	2016
Pages	413-418
ISBN (Print)	9781493930227
DOIs	https://doi.org/10.1007/978-1-4939-3023-4_52
Publication status	Published - 2016
Event	42nd Annual Meeting of International Society on Oxygen Transport to Tissue - London, United Kingdom Duration: 28 Jun 2014 → 3 Jul 2014

Conference

Conference	42nd Annual Meeting of International Society on Oxygen Transport to Tissue
Country/Territory	United Kingdom
City	London
Period	28/06/2014 → 03/07/2014
Sponsor	Baker Ruskinn, Etal, Hamamatsu Photonics KK, Hitachi High-Technologies, Seahorse Bioscience, University College London

Series	Advances in Experimental Medicine and Biology
Volume	876
ISSN	0065-2598

Keywords

Comparison
Instrumentation
Liquid phantom
Near-infrared spectroscopy
Water correction

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10.1007/978-1-4939-3023-4_52

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Comparison of near-infrared oximeters in a liquid optical phantom with varying intralipid and blood content. / Kleiserstefan, S.; Hyttel-Sorensen, S.; Greisen, G. et al.
Oxygen Transport to Tissue XXXVII. ed. / Clare E. Elwell; Terence S. Leung; David K. Harrison. Springer New York LLC, 2016. p. 413-418 (Advances in Experimental Medicine and Biology, Vol. 876).

Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review

Kleiserstefan, S, Hyttel-Sorensen, S , Greisen, G & Wolf, M 2016, Comparison of near-infrared oximeters in a liquid optical phantom with varying intralipid and blood content. in CE Elwell, TS Leung & DK Harrison (eds), Oxygen Transport to Tissue XXXVII. Springer New York LLC, Advances in Experimental Medicine and Biology, vol. 876, pp. 413-418, 42nd Annual Meeting of International Society on Oxygen Transport to Tissue, London, United Kingdom, 28/06/2014. https://doi.org/10.1007/978-1-4939-3023-4_52

Kleiserstefan S, Hyttel-Sorensen S , Greisen G, Wolf M. Comparison of near-infrared oximeters in a liquid optical phantom with varying intralipid and blood content. In Elwell CE, Leung TS, Harrison DK, editors, Oxygen Transport to Tissue XXXVII. Springer New York LLC. 2016. p. 413-418. (Advances in Experimental Medicine and Biology, Vol. 876). doi: 10.1007/978-1-4939-3023-4_52

Kleiserstefan, S. ; Hyttel-Sorensen, S. ; Greisen, G. et al. / Comparison of near-infrared oximeters in a liquid optical phantom with varying intralipid and blood content. Oxygen Transport to Tissue XXXVII. editor / Clare E. Elwell ; Terence S. Leung ; David K. Harrison. Springer New York LLC, 2016. pp. 413-418 (Advances in Experimental Medicine and Biology, Vol. 876).

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abstract = "The interpretation of cerebral tissue oxygen saturation values (StO2) in clinical settings is currently complicated by the use of different near-infrared spectrophotometry (NIRS) devices producing different StO2 values for the same oxygenation due to differences in the algorithms and technical aspects. The aim was to investigate the effect of changes in scattering and absorption on the StO2 of different NIRS devices in a liquid optical phantom. We compared three continuous-wave (CW) with a frequency domain (FD) NIRS device. Responsiveness to oxygenation changes was only slightly altered by different intralipid (IL) concentrations. However, alterations in haematocrit (htc) showed a strong effect: increased htc led to a 20–35%increased response of allCWdevices compared to the FD device, probably due to differences in algorithms regarding the water concentration.",

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N1 - Funding Information: This work was scientifically evaluated by the SNSF, partially financed by the Swiss Confederation and funded by Nano-Tera.ch as well the Danish Council for Strategic Research (SafeBoosC project), which the authors would like to gratefully acknowledge. Publisher Copyright: © Springer Science+Business Media, New York 2016.

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AB - The interpretation of cerebral tissue oxygen saturation values (StO2) in clinical settings is currently complicated by the use of different near-infrared spectrophotometry (NIRS) devices producing different StO2 values for the same oxygenation due to differences in the algorithms and technical aspects. The aim was to investigate the effect of changes in scattering and absorption on the StO2 of different NIRS devices in a liquid optical phantom. We compared three continuous-wave (CW) with a frequency domain (FD) NIRS device. Responsiveness to oxygenation changes was only slightly altered by different intralipid (IL) concentrations. However, alterations in haematocrit (htc) showed a strong effect: increased htc led to a 20–35%increased response of allCWdevices compared to the FD device, probably due to differences in algorithms regarding the water concentration.

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Comparison of near-infrared oximeters in a liquid optical phantom with varying intralipid and blood content

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