Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Comparison of methods for measuring antibiotic consumption in an intensive care unit

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Bacteremia and urogenital infection with Actinomyces urogenitalis following prolonged urinary retention

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Two cases of tick-borne transmitted tularemia on Southern Zealand, Denmark

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Analysis of proximal bone margins in diabetic foot osteomyelitis by conventional culture, DNA sequencing and microscopy

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Erythrocytes restrict microvesicle-induced production of reactive oxygen species by polymorphonuclear leukocytes

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. The impact of concurrent HIV and type II diabetes on immune maturation, immune regulation and immune activation

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Community-acquired meningitis caused by beta-haemolytic streptococci in adults: a nationwide population-based cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Transcerebral exchange kinetics of large neutral amino acids during acute inspiratory hypoxia in humans

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. LISTERIA MENINGITIS IN DANISH CHILDREN 2000-2017: A Rare Event Even in a Country With High Rates of Invasive Listeriosis

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Delayed cerebral ischaemia in patients with aneurysmal subarachnoid haemorrhage: Functional outcome and long-term mortality

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Hospitals worldwide are working on minimizing unnecessary use of antimicrobials. To assess actual changes of antimicrobial usage, correct and precise measurements are necessary. This study aimed to compare data on the purchase of antibiotics from the pharmacy and the administration of antibiotics to patients, respectively, in an intensive care unit (ICU). Data were obtained from the Neurointensive Care Unit (NICU) at Rigshospitalet, Denmark. During a 23-month period, comprising 10 770 bed-days (BD), the ward purchased 16 908 defined daily doses (DDD) of antibiotics from the pharmacy, and 15 130 DDD and 41 304 individual doses were administered. Intraclass correlation coefficients (ICCs) were calculated; control and runcharts and a Bland-Altman plot were constructed. Pharmacy sales and drug administration data showed no systematic variation over time with a monthly overestimation of pharmacy sales data of 10% (95% confidence interval (CI), 6.20-14.3%) for all antibiotics, and 7% (95% CI: 1.81-11.1%) for broad-spectrum antibiotics. The antibiotic consumption, without bed-days, has a clinically acceptable ICC of >0.70 and no systematic difference is suggested by the Bland-Altman plot. In this study of a large NICU, whose antibiotic consumption varied at random, pharmacy sales data were an acceptable approximation of the actual summarized drug consumption.

Original languageEnglish
JournalAPMIS - Journal of Pathology, Microbiology and Immunology
Volume127
Issue number1
Pages (from-to)33-40
Number of pages8
ISSN0903-4641
DOIs
Publication statusPublished - 14 Dec 2018

ID: 55881616