Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Comparison of methods for estimating glomerular filtration rate in head and neck cancer patients treated with cisplatin

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Platelet function in lung cancer patients undergoing lobectomy

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Platelet increment is not associated with endothelial damage in haematological patients: a prospective observational study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Change in HbA1c concentration as decision parameter for frequency of HbA1c measurement

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Relation between invasive hemodynamics and measured glomerular filtration rate by 51Cr-EDTA clearance in advanced heart failure

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Validation of plasma thyroxine and triiodothyronine methods on the ADVIA Centaur® XP

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. 5-year outcome after complete mesocolic excision for right-sided colon cancer: a population-based cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Completeness of RET testing in patients with medullary thyroid carcinoma in Denmark 1997-2013: a nationwide study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Replication of newly proposed TNM staging system for medullary thyroid carcinoma: a nationwide study

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Cisplatin is a chemotherapeutic agent widely used in the treatment of various solid tumors. Cisplatin induces nephrotoxicity and may lead to long-term reduction of kidney function. Consequently, determination of glomerular filtration rate (GFR) is used to monitor potential kidney damage. This study aimed to compare two commonly used algorithms for estimating GFR (eGFR) from plasma creatinine (PCr) with 51Cr-EDTA clearance (CrCl) as a reference method. This was a retrospective single center study of 94 head and neck cancer patients treated with cisplatin. CrCl was performed once before, during, and after treatment, and PCr was measured concurrently. eGFR was assessed from PCr applying the Cockcroft-Gault (CG) and the Chronic Kidney Disease-Epidemiology Collaboration (CKD-EPI) equations. Agreement was assessed applying the statistical methods of Bland and Altman. A predefined limit of clinically acceptable variation between CrCl and eGFR of 14% was applied. Comparison of CrCl and eGFRCKD revealed a positive slope of the linear regression line, suggesting proportional bias (p < 0.001). No systematic bias was found for eGFRCG. Pre-treatment, 42 (46%), 53 (56%) and 48 (53%) observations were within the clinically acceptable limit of variation for standardized eGFRCKD, BSA corrected eGFRCKD, and eGFRCG, respectively. The observed body weight changes were significant. In conclusion, estimated GFRCKD cannot sufficiently replace CrCl in the assessment of GFR during treatment with cisplatin due to systematic bias. Consequently, if CrCl is unavailable, then the CG equation is the better choice provided proper attention is paid to the large variation between methods.

Original languageEnglish
JournalScandinavian Journal of Clinical and Laboratory Investigation
Volume77
Issue number4
Pages (from-to)237-246
Number of pages10
ISSN0036-5513
DOIs
Publication statusPublished - Jul 2017

    Research areas

  • Journal Article

ID: 52652150