Abstract
Histamine release (HR) after stimulation with anti-IgE, concanavalin A (ConA) and Formyl-Met-Leu-Phe (FMLP) from 97 cord blood samples was compared to results obtained in identically treated blood samples from adults. The maximal HR obtained with anti-IgE did not differ significantly from the values obtained in adult blood, although a ten times higher concentration of anti-IgE was required for maximum release. Passive sensitization with IgE-rich plasma caused a significant increase in maximal anti-IgE-induced HR in the majority of cord blood samples, and the dose-response curve was similar to that obtained in adult blood. Challenge with ConA and FMLP caused a HR similar to that seen in adult blood, but the close correlation between anti-IgE- and concanavalin A-induced HR seen in adult blood was absent in cord blood.
| Original language | English |
|---|---|
| Journal | Agents and Actions |
| Volume | 33 |
| Issue number | 1-2 |
| Pages (from-to) | 64-6 |
| Number of pages | 3 |
| ISSN | 0065-4299 |
| DOIs | |
| Publication status | Published - May 1991 |
| Externally published | Yes |
Keywords
- Aging/blood
- Antibodies, Anti-Idiotypic/pharmacology
- Basophils/drug effects
- Concanavalin A/pharmacology
- Fetal Blood/metabolism
- Histamine/blood
- Histamine Release/drug effects
- Immunoglobulin E/immunology
- N-Formylmethionine Leucyl-Phenylalanine/pharmacology