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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Comparison of Cytokines in Skin Biopsies and Tape Strips from Adults with Atopic Dermatitis

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Skin biomarkers for disease severity and treatment response in atopic dermatitis (AD) are needed. Biopsies cause scarring and tape stripping represents an alternative minimally invasive method for stratum corneum sampling. In this study, we examined the gene expression of cytokines in skin biopsies and cytokines in stratum corneum tape strips collected from adults with AD. We collected punch biopsies and tape strips from healthy controls (n = 6) and subjects with AD (n = 12) at baseline and after 2 weeks of topical treatment with mometasone furoate 0.1% cream. We found that IFN-γ, IL-13, and IL-10 mRNA (biopsies) and IL-1β protein expression levels (tape strips) were significantly increased in lesional AD skin compared to healthy control skin. Treatment with topical corticosteroid led to a significant decrease in mRNA levels for IL-13 and IL-4R but no significant differences in cytokine protein levels measured in tape strips. Finally, we found no significant correlations between cytokine levels in tape strips and mRNA levels in skin biopsies.

Original languageEnglish
JournalDermatology
Volume237
Issue number6
Pages (from-to)940-945
Number of pages6
ISSN1018-8665
DOIs
Publication statusPublished - 1 Nov 2021

Bibliographical note

Publisher Copyright:
© 2021 S. Karger AG. All rights reserved.

    Research areas

  • Atopic dermatitis, Immunology, Skin inflammation

ID: 69204550