Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Comparison of 81mKrypton and 99mTc-Technegas for ventilation single-photon emission computed tomography in severe chronic obstructive pulmonary disease

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Effect of blood glucose and body weight on image quality in brain [18F]FDG PET imaging

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Improving quantitative dosimetry in (177)Lu-DOTATATE SPECT by energy window-based scatter corrections

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Calibrated image-derived input functions for the determination of the metabolic uptake rate of glucose with [18F]-FDG PET

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Determination of kidney function with 99mTc-DTPA renography using a dual-head camera

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. A comparison of different energy window subtraction methods to correct for scatter and downscatter in I-123 SPECT imaging

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Lung Ultrasound to Phenotype Chronic Lung Allograft Dysfunction in Lung Transplant Recipients. A Prospective Observational Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Prognostic impact of ventilation-perfusion defects and pulmonary diffusing capacity after single lung transplantation

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Lung volume reduction surgery as salvage procedure after previous use of endobronchial valves

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

INTRODUCTION: Ventilation and perfusion single-photon emission computed tomography combined with computed tomography (SPECT/CT) is a powerful tool to assess the state of the lungs in chronic obstructive pulmonary disease (COPD). 81mKrypton is a gaseous ventilation tracer and distributes similarly to air, but is not widely available and relatively expensive. 99mTc-Technegas is cheaper and has wider availability, but is an aerosol, which may deposit in hot spots as the severity of COPD increases. In this study, 81mKrypton and 99mTc-Technegas were compared quantitatively in patients with severe COPD.

METHODS: The penetration ratio, the heterogeneity index (with and without band filtering for relevant clinical sizes) and hot spot appearance were assessed in eleven patients with severe COPD that underwent simultaneous dual-isotope ventilation SPECT/CT with both 99mTc-Technegas and 81mKrypton.

RESULTS: Significant differences were found in the penetration ratio for the medium energy general purpose (MEGP) collimators, but not for the low energy general purpose (LEGP) collimators. The difference in the overall and the band filtered heterogeneity index was significant in most cases. All patients suffered from 99mTc-Technegas hot spots in at least one lung. Comparison of MEGP 81mKrypton and LEGP Technegas scans revealed similar results as the comparison for the MEGP collimators.

CONCLUSION: Caution should be taken when replacing 81mKrypton with 99mTc-Technegas as a ventilation tracer in patients with severe COPD as there are significant differences in the distribution of the tracers over the lungs. Furthermore, this patient group is prone to 99mTc-Technegas hot spots and might need additional scanning if hot spots severely hamper image interpretation.

Original languageEnglish
JournalNuclear Medicine Communications
Volume42
Issue number2
Pages (from-to)160-168
Number of pages9
ISSN0143-3636
DOIs
Publication statusPublished - 1 Feb 2021

Bibliographical note

Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc.

ID: 61545947