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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Comparing the harmful effects of nontuberculous mycobacteria and Gram negative bacteria on lung function in patients with cystic fibrosis

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  1. Markers of bone turnover are reduced in patients with CF related diabetes; the role of glucose

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  2. Seasonal fluctuation of lung function in cystic fibrosis: A national register-based study in two northern European populations

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  3. Antibody response against Mycobacterium avium complex in cystic fibrosis patients measured by a novel IgG ELISA test

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  4. Defining antimicrobial resistance in cystic fibrosis

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  5. The choice of lung function reference equation affects clinical trial eligibility: Results from a cystic fibrosis cohort

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  1. How to Identify Common Variable Immunodeficiency Patients Earlier: General Practice Patterns

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  2. Syphilitic hepatitis and neurosyphilis: an observational study of Danish HIV-infected individuals during a 13-year period

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Markers of bone turnover are reduced in patients with CF related diabetes; the role of glucose

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Seasonal fluctuation of lung function in cystic fibrosis: A national register-based study in two northern European populations

    Research output: Contribution to journalJournal articleResearchpeer-review

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BACKGROUND: To better understand the relative effects of infection with nontuberculous mycobacteria and Gram negative bacteria on lung function decline in cystic fibrosis, we assessed the impact of each infection in a Danish setting.

METHODS: Longitudinal registry study of 432 patients with cystic fibrosis contributing 53,771 lung function measures between 1974 and 2014. We used a mixed effects model with longitudinally structured correlation, while adjusting for clinically important covariates.

RESULTS: Infections with a significant impact on rate of decline in %FEV1 were Mycobacterium abscessus complex with -2.22% points per year (95% CI -3.21 to -1.23), Burkholderia cepacia complex -1.95% (95% CI -2.51 to -1.39), Achromobacterxylosoxidans -1.55% (95% CI -2.21 to -0.90), and Pseudomonas aeruginosa -0.95% (95% CI -1.24 to -0.66). Clearing M. abscessus complex was associated with a change to a slower decline, similar in magnitude to the pre-infection slope.

CONCLUSIONS: In a national population we have demonstrated the impact on lung function of each chronic CF pathogen. M. abscessus complex was associated with the worst impact on lung function. Eradication of M. abscessus complex may significantly improve lung function.

Original languageEnglish
JournalJournal of cystic fibrosis : official journal of the European Cystic Fibrosis Society
Volume15
Issue number3
Pages (from-to)380-5
ISSN1569-1993
DOIs
Publication statusPublished - 2016

ID: 45746168