Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

COMPARATIVE EFFECTIVENESS OF PROTON BEAM VERSUS PHOTODYNAMIC THERAPY TO SPARE THE VISION IN CIRCUMSCRIBED CHOROIDAL HEMANGIOMA

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Mathis, T, Maschi, C, Mosci, C, Espensen, CA, Rosier, L, Favard, C, Tick, S, Remignon, C-H, Ligorio, P, Bonin, N, Gambrelle, J, Nguyen, A-M, Faber, C, Meyer, L, Mouriaux, F, Herault, J, Baillif, S, Kiilgaard, J-F, Kodjikian, L, Caujolle, J-P, Salleron, J & Thariat, J 2021, 'COMPARATIVE EFFECTIVENESS OF PROTON BEAM VERSUS PHOTODYNAMIC THERAPY TO SPARE THE VISION IN CIRCUMSCRIBED CHOROIDAL HEMANGIOMA', Retina (Philadelphia, Pa.), vol. 41, no. 2, pp. 277-286. https://doi.org/10.1097/IAE.0000000000002843

APA

Mathis, T., Maschi, C., Mosci, C., Espensen, C. A., Rosier, L., Favard, C., Tick, S., Remignon, C-H., Ligorio, P., Bonin, N., Gambrelle, J., Nguyen, A-M., Faber, C., Meyer, L., Mouriaux, F., Herault, J., Baillif, S., Kiilgaard, J-F., Kodjikian, L., ... Thariat, J. (2021). COMPARATIVE EFFECTIVENESS OF PROTON BEAM VERSUS PHOTODYNAMIC THERAPY TO SPARE THE VISION IN CIRCUMSCRIBED CHOROIDAL HEMANGIOMA. Retina (Philadelphia, Pa.), 41(2), 277-286. https://doi.org/10.1097/IAE.0000000000002843

CBE

Mathis T, Maschi C, Mosci C, Espensen CA, Rosier L, Favard C, Tick S, Remignon C-H, Ligorio P, Bonin N, Gambrelle J, Nguyen A-M, Faber C, Meyer L, Mouriaux F, Herault J, Baillif S, Kiilgaard J-F, Kodjikian L, Caujolle J-P, Salleron J, Thariat J. 2021. COMPARATIVE EFFECTIVENESS OF PROTON BEAM VERSUS PHOTODYNAMIC THERAPY TO SPARE THE VISION IN CIRCUMSCRIBED CHOROIDAL HEMANGIOMA. Retina (Philadelphia, Pa.). 41(2):277-286. https://doi.org/10.1097/IAE.0000000000002843

MLA

Vancouver

Author

Mathis, Thibaud ; Maschi, Célia ; Mosci, Carlo ; Espensen, Charlotte A ; Rosier, Laurence ; Favard, Catherine ; Tick, Sarah ; Remignon, Charles-Henry ; Ligorio, Paolo ; Bonin, Nicolas ; Gambrelle, Joël ; Nguyen, Anh-Minh ; Faber, Carsten ; Meyer, Laurent ; Mouriaux, Frederic ; Herault, Joël ; Baillif, Stéphanie ; Kiilgaard, Jens-Folke ; Kodjikian, Laurent ; Caujolle, Jean-Pierre ; Salleron, Julia ; Thariat, Juliette. / COMPARATIVE EFFECTIVENESS OF PROTON BEAM VERSUS PHOTODYNAMIC THERAPY TO SPARE THE VISION IN CIRCUMSCRIBED CHOROIDAL HEMANGIOMA. In: Retina (Philadelphia, Pa.). 2021 ; Vol. 41, No. 2. pp. 277-286.

Bibtex

@article{dd458c2afc7c42abab882de106421733,
title = "COMPARATIVE EFFECTIVENESS OF PROTON BEAM VERSUS PHOTODYNAMIC THERAPY TO SPARE THE VISION IN CIRCUMSCRIBED CHOROIDAL HEMANGIOMA",
abstract = "PURPOSE: The aim of this study was to compare the functional and anatomical effectiveness of photodynamic therapy (PDT) versus proton beam therapy (PBT) in a real-life setting for the treatment of circumscribed choroidal hemangioma.METHODS: A total of 191 patients with a diagnosis of circumscribed choroidal hemangioma and treated by PBT or PDT were included for analyses.RESULTS: The 119 patients (62.3%) treated by PDT were compared with the 72 patients treated by PBT. The final best-corrected visual acuity did not differ significantly between the two groups (P = 0.932) and final thickness was lower in the PBT compared with the PDT group (P = 0.001). None of the patients treated by PBT needed second-line therapy. In comparison, 53 patients (44.5%) initially treated by PDT required at least one other therapy and were associated with worse final best-corrected visual acuity (P = 0.037). In multivariate analysis, only an initial thickness greater than 3 mm remained significant (P = 0.01) to predict PDT failure with an estimated odds ratio of 2.72, 95% confidence interval (1.25-5.89).CONCLUSION: Photodynamic therapy and PBT provide similar anatomical and functional outcomes for circumscribed choroidal hemangioma ≤3 mm, although multiple sessions are sometimes required for PDT. For tumors >3 mm, PBT seems preferable because it can treat the tumor in only 1 session with better functional and anatomical outcomes.",
keywords = "circumscribed choroidal hemangioma, ocular oncology, photodynamic therapy, proton beam therapy, radiation therapy, Protons, Photosensitizing Agents/therapeutic use, Fluorescein Angiography/methods, Choroid Neoplasms/diagnosis, Follow-Up Studies, Tomography, Optical Coherence, Humans, Middle Aged, Male, Photochemotherapy/methods, Treatment Outcome, Choroid/pathology, Visual Acuity, Porphyrins/therapeutic use, Hemangioma/diagnosis, Female, Retrospective Studies, Verteporfin/therapeutic use",
author = "Thibaud Mathis and C{\'e}lia Maschi and Carlo Mosci and Espensen, {Charlotte A} and Laurence Rosier and Catherine Favard and Sarah Tick and Charles-Henry Remignon and Paolo Ligorio and Nicolas Bonin and Jo{\"e}l Gambrelle and Anh-Minh Nguyen and Carsten Faber and Laurent Meyer and Frederic Mouriaux and Jo{\"e}l Herault and St{\'e}phanie Baillif and Jens-Folke Kiilgaard and Laurent Kodjikian and Jean-Pierre Caujolle and Julia Salleron and Juliette Thariat",
year = "2021",
month = feb,
day = "1",
doi = "10.1097/IAE.0000000000002843",
language = "English",
volume = "41",
pages = "277--286",
journal = "Retina",
issn = "0275-004X",
publisher = "Lippincott Williams & Wilkins",
number = "2",

}

RIS

TY - JOUR

T1 - COMPARATIVE EFFECTIVENESS OF PROTON BEAM VERSUS PHOTODYNAMIC THERAPY TO SPARE THE VISION IN CIRCUMSCRIBED CHOROIDAL HEMANGIOMA

AU - Mathis, Thibaud

AU - Maschi, Célia

AU - Mosci, Carlo

AU - Espensen, Charlotte A

AU - Rosier, Laurence

AU - Favard, Catherine

AU - Tick, Sarah

AU - Remignon, Charles-Henry

AU - Ligorio, Paolo

AU - Bonin, Nicolas

AU - Gambrelle, Joël

AU - Nguyen, Anh-Minh

AU - Faber, Carsten

AU - Meyer, Laurent

AU - Mouriaux, Frederic

AU - Herault, Joël

AU - Baillif, Stéphanie

AU - Kiilgaard, Jens-Folke

AU - Kodjikian, Laurent

AU - Caujolle, Jean-Pierre

AU - Salleron, Julia

AU - Thariat, Juliette

PY - 2021/2/1

Y1 - 2021/2/1

N2 - PURPOSE: The aim of this study was to compare the functional and anatomical effectiveness of photodynamic therapy (PDT) versus proton beam therapy (PBT) in a real-life setting for the treatment of circumscribed choroidal hemangioma.METHODS: A total of 191 patients with a diagnosis of circumscribed choroidal hemangioma and treated by PBT or PDT were included for analyses.RESULTS: The 119 patients (62.3%) treated by PDT were compared with the 72 patients treated by PBT. The final best-corrected visual acuity did not differ significantly between the two groups (P = 0.932) and final thickness was lower in the PBT compared with the PDT group (P = 0.001). None of the patients treated by PBT needed second-line therapy. In comparison, 53 patients (44.5%) initially treated by PDT required at least one other therapy and were associated with worse final best-corrected visual acuity (P = 0.037). In multivariate analysis, only an initial thickness greater than 3 mm remained significant (P = 0.01) to predict PDT failure with an estimated odds ratio of 2.72, 95% confidence interval (1.25-5.89).CONCLUSION: Photodynamic therapy and PBT provide similar anatomical and functional outcomes for circumscribed choroidal hemangioma ≤3 mm, although multiple sessions are sometimes required for PDT. For tumors >3 mm, PBT seems preferable because it can treat the tumor in only 1 session with better functional and anatomical outcomes.

AB - PURPOSE: The aim of this study was to compare the functional and anatomical effectiveness of photodynamic therapy (PDT) versus proton beam therapy (PBT) in a real-life setting for the treatment of circumscribed choroidal hemangioma.METHODS: A total of 191 patients with a diagnosis of circumscribed choroidal hemangioma and treated by PBT or PDT were included for analyses.RESULTS: The 119 patients (62.3%) treated by PDT were compared with the 72 patients treated by PBT. The final best-corrected visual acuity did not differ significantly between the two groups (P = 0.932) and final thickness was lower in the PBT compared with the PDT group (P = 0.001). None of the patients treated by PBT needed second-line therapy. In comparison, 53 patients (44.5%) initially treated by PDT required at least one other therapy and were associated with worse final best-corrected visual acuity (P = 0.037). In multivariate analysis, only an initial thickness greater than 3 mm remained significant (P = 0.01) to predict PDT failure with an estimated odds ratio of 2.72, 95% confidence interval (1.25-5.89).CONCLUSION: Photodynamic therapy and PBT provide similar anatomical and functional outcomes for circumscribed choroidal hemangioma ≤3 mm, although multiple sessions are sometimes required for PDT. For tumors >3 mm, PBT seems preferable because it can treat the tumor in only 1 session with better functional and anatomical outcomes.

KW - circumscribed choroidal hemangioma

KW - ocular oncology

KW - photodynamic therapy

KW - proton beam therapy

KW - radiation therapy

KW - Protons

KW - Photosensitizing Agents/therapeutic use

KW - Fluorescein Angiography/methods

KW - Choroid Neoplasms/diagnosis

KW - Follow-Up Studies

KW - Tomography, Optical Coherence

KW - Humans

KW - Middle Aged

KW - Male

KW - Photochemotherapy/methods

KW - Treatment Outcome

KW - Choroid/pathology

KW - Visual Acuity

KW - Porphyrins/therapeutic use

KW - Hemangioma/diagnosis

KW - Female

KW - Retrospective Studies

KW - Verteporfin/therapeutic use

UR - http://www.scopus.com/inward/record.url?scp=85100224286&partnerID=8YFLogxK

U2 - 10.1097/IAE.0000000000002843

DO - 10.1097/IAE.0000000000002843

M3 - Journal article

C2 - 32404844

VL - 41

SP - 277

EP - 286

JO - Retina

JF - Retina

SN - 0275-004X

IS - 2

ER -

ID: 59853101