Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

COMPARATIVE EFFECTIVENESS OF PROTON BEAM VERSUS PHOTODYNAMIC THERAPY TO SPARE THE VISION IN CIRCUMSCRIBED CHOROIDAL HEMANGIOMA

Research output: Contribution to journalJournal articleResearchpeer-review

  1. GAS-FOVEAL CONTACT: A New Approach to Evaluating Positioning Regimens in Macular Hole Surgery

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. SCLERAL PITS IN CHOROIDEREMIA: Implications for Retinal Gene Therapy

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Reply to reply ( NONSUPINE POSITIONING IN MACULAR HOLE SURGERY: A Noninferiority Randomized Clinical Trial.)

    Research output: Contribution to journalComment/debateResearchpeer-review

  4. GUNN'S DOTS IN RETINAL IMAGES OF 2,286 ADOLESCENTS: Prevalence, Retinal Distribution and Associations

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. 3D image-guided treatment planning for Ruthenium-106 brachytherapy of choroidal melanomas

    Research output: Contribution to journalReviewpeer-review

  2. Seasonal variation in biopsy-proven giant cell arteritis in Eastern Denmark from 1990-2018

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Measuring aniseikonia tolerance range for stereoacuity - a tool for the refractive surgeon

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Dose-Response and Normal Tissue Complication Probabilities after Proton Therapy for Choroidal Melanoma

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Thibaud Mathis
  • Célia Maschi
  • Carlo Mosci
  • Charlotte A Espensen
  • Laurence Rosier
  • Catherine Favard
  • Sarah Tick
  • Charles-Henry Remignon
  • Paolo Ligorio
  • Nicolas Bonin
  • Joël Gambrelle
  • Anh-Minh Nguyen
  • Carsten Faber
  • Laurent Meyer
  • Frederic Mouriaux
  • Joël Herault
  • Stéphanie Baillif
  • Jens-Folke Kiilgaard
  • Laurent Kodjikian
  • Jean-Pierre Caujolle
  • Julia Salleron
  • Juliette Thariat
View graph of relations

PURPOSE: The aim of this study was to compare the functional and anatomical effectiveness of photodynamic therapy (PDT) versus proton beam therapy (PBT) in a real-life setting for the treatment of circumscribed choroidal hemangioma.

METHODS: A total of 191 patients with a diagnosis of circumscribed choroidal hemangioma and treated by PBT or PDT were included for analyses.

RESULTS: The 119 patients (62.3%) treated by PDT were compared with the 72 patients treated by PBT. The final best-corrected visual acuity did not differ significantly between the two groups (P = 0.932) and final thickness was lower in the PBT compared with the PDT group (P = 0.001). None of the patients treated by PBT needed second-line therapy. In comparison, 53 patients (44.5%) initially treated by PDT required at least one other therapy and were associated with worse final best-corrected visual acuity (P = 0.037). In multivariate analysis, only an initial thickness greater than 3 mm remained significant (P = 0.01) to predict PDT failure with an estimated odds ratio of 2.72, 95% confidence interval (1.25-5.89).

CONCLUSION: Photodynamic therapy and PBT provide similar anatomical and functional outcomes for circumscribed choroidal hemangioma ≤3 mm, although multiple sessions are sometimes required for PDT. For tumors >3 mm, PBT seems preferable because it can treat the tumor in only 1 session with better functional and anatomical outcomes.

Original languageEnglish
JournalRetina (Philadelphia, Pa.)
Volume41
Issue number2
Pages (from-to)277-286
Number of pages10
ISSN0275-004X
DOIs
Publication statusPublished - 1 Feb 2021

    Research areas

  • circumscribed choroidal hemangioma, ocular oncology, photodynamic therapy, proton beam therapy, radiation therapy

ID: 59853101