Comorbidities in Chilean patients with psoriasis: a Global Healthcare Study on Psoriasis

Fernando Valenzuela; Claudia De La Cruz; Cristóbal Lecaros; Javier Fernández; Gonzalo Hevia; Lara Valeska Maul; Jacob P Thyssen; Cristián Vera-Kellet; Alexander Egeberg; Daniela Armijo; Cristian Pizarro; Tatiana Riveros; Hernán Correa; Antonio Guglielmetti; Johannes A Didaskalu; Jashin J Wu; Christopher E M Griffiths; Ricardo Romiti; Julia-Tatjana Maul

doi:10.1111/ced.15384

Comorbidities in Chilean patients with psoriasis: a Global Healthcare Study on Psoriasis

Fernando Valenzuela, Claudia De La Cruz, Cristóbal Lecaros, Javier Fernández, Gonzalo Hevia, Lara Valeska Maul, Jacob P Thyssen, Cristián Vera-Kellet, Alexander Egeberg, Daniela Armijo, Cristian Pizarro, Tatiana Riveros, Hernán Correa, Antonio Guglielmetti, Johannes A Didaskalu, Jashin J Wu, Christopher E M Griffiths, Ricardo Romiti, Julia-Tatjana Maul

Dermatology, Department of

Abstract

BACKGROUND: Psoriasis is a chronic inflammatory skin disease associated with several important medical comorbidities. There are scant data available on the comorbidities of patients with psoriasis in South America.

AIM: To examine the comorbidity profile of adult patients with psoriasis in Chile and its association with severity of psoriasis.

METHODS: This was a multicentre, cross-sectional study involving 16 hospitals and clinics in Chile, which used a 48-item questionnaire to study clinician- and patient-reported outcomes and comorbidities. Inferential analyses were performed by psoriasis severity, using Fisher exact test, Student t-test and multivariable logistic regression.

RESULTS: In total, 598 adult patients with psoriasis were included (51.1% male; mean age 49.2 ± 15.1 years); 48.5% mild and 51.4% moderate to severe; Psoriasis Area and Severity Index 11.6 ± 11.5; body surface area 14.7 ± 18.2%. Plaque psoriasis was the most common phenotype (90.2%), followed by guttate (13.4%). Psoriatic arthritis occurred in 27.3% of patients. Comorbidities were reported in 60.2% of all patients with psoriasis. Frequent concomitant diseases were obesity (25.3%), hypertension (24.3%), Type 2 diabetes mellitus (T2DM) (18.7%), dyslipidaemia (17.4%), metabolic syndrome (16.7%) and depression (14.4%). After adjustment, significant associations were found between moderate to severe psoriasis and obesity, T2DM and nonalcoholic fatty liver disease (NAFLD) compared with mild psoriasis.

CONCLUSIONS: We report a large study of comorbidities, including depression, dyslipidaemia, T2DM and NAFLD, in people with psoriasis in Chile. The prevalence of comorbidities with psoriasis in Chile appears similar to that found in Western countries, and emphasizes the importance of assessing patients with psoriasis for risk factors for and presence of, comorbid disease in a multidisciplinary setting.

Original language	English
Journal	Clinical and Experimental Dermatology
Volume	47
Issue number	12
Pages (from-to)	2234-2241
Number of pages	8
ISSN	0307-6938
DOIs	https://doi.org/10.1111/ced.15384
Publication status	Published - Dec 2022

Keywords

Male
Female
Humans
Non-alcoholic Fatty Liver Disease/epidemiology
Chile/epidemiology
Diabetes Mellitus, Type 2/epidemiology
Cross-Sectional Studies
Psoriasis/epidemiology
Comorbidity
Obesity/epidemiology
Dyslipidemias
Delivery of Health Care

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10.1111/ced.15384

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Valenzuela, F., De La Cruz, C., Lecaros, C., Fernández, J., Hevia, G., Maul, L. V., Thyssen, J. P., Vera-Kellet, C., Egeberg, A., Armijo, D., Pizarro, C., Riveros, T., Correa, H., Guglielmetti, A., Didaskalu, J. A., Wu, J. J., Griffiths, C. E. M., Romiti, R., & Maul, J-T. (2022). Comorbidities in Chilean patients with psoriasis: a Global Healthcare Study on Psoriasis. Clinical and Experimental Dermatology, 47(12), 2234-2241. https://doi.org/10.1111/ced.15384

Valenzuela, F, De La Cruz, C, Lecaros, C, Fernández, J, Hevia, G, Maul, LV, Thyssen, JP, Vera-Kellet, C, Egeberg, A, Armijo, D, Pizarro, C, Riveros, T, Correa, H, Guglielmetti, A, Didaskalu, JA, Wu, JJ, Griffiths, CEM, Romiti, R & Maul, J-T 2022, 'Comorbidities in Chilean patients with psoriasis: a Global Healthcare Study on Psoriasis', Clinical and Experimental Dermatology, vol. 47, no. 12, pp. 2234-2241. https://doi.org/10.1111/ced.15384

@article{6daea620f8b24f61b8b4521e982caecc,

title = "Comorbidities in Chilean patients with psoriasis: a Global Healthcare Study on Psoriasis",

abstract = "BACKGROUND: Psoriasis is a chronic inflammatory skin disease associated with several important medical comorbidities. There are scant data available on the comorbidities of patients with psoriasis in South America.AIM: To examine the comorbidity profile of adult patients with psoriasis in Chile and its association with severity of psoriasis.METHODS: This was a multicentre, cross-sectional study involving 16 hospitals and clinics in Chile, which used a 48-item questionnaire to study clinician- and patient-reported outcomes and comorbidities. Inferential analyses were performed by psoriasis severity, using Fisher exact test, Student t-test and multivariable logistic regression.RESULTS: In total, 598 adult patients with psoriasis were included (51.1% male; mean age 49.2 ± 15.1 years); 48.5% mild and 51.4% moderate to severe; Psoriasis Area and Severity Index 11.6 ± 11.5; body surface area 14.7 ± 18.2%. Plaque psoriasis was the most common phenotype (90.2%), followed by guttate (13.4%). Psoriatic arthritis occurred in 27.3% of patients. Comorbidities were reported in 60.2% of all patients with psoriasis. Frequent concomitant diseases were obesity (25.3%), hypertension (24.3%), Type 2 diabetes mellitus (T2DM) (18.7%), dyslipidaemia (17.4%), metabolic syndrome (16.7%) and depression (14.4%). After adjustment, significant associations were found between moderate to severe psoriasis and obesity, T2DM and nonalcoholic fatty liver disease (NAFLD) compared with mild psoriasis.CONCLUSIONS: We report a large study of comorbidities, including depression, dyslipidaemia, T2DM and NAFLD, in people with psoriasis in Chile. The prevalence of comorbidities with psoriasis in Chile appears similar to that found in Western countries, and emphasizes the importance of assessing patients with psoriasis for risk factors for and presence of, comorbid disease in a multidisciplinary setting.",

keywords = "Male, Female, Humans, Non-alcoholic Fatty Liver Disease/epidemiology, Chile/epidemiology, Diabetes Mellitus, Type 2/epidemiology, Cross-Sectional Studies, Psoriasis/epidemiology, Comorbidity, Obesity/epidemiology, Dyslipidemias, Delivery of Health Care",

author = "Fernando Valenzuela and {De La Cruz}, Claudia and Crist{\'o}bal Lecaros and Javier Fern{\'a}ndez and Gonzalo Hevia and Maul, {Lara Valeska} and Thyssen, {Jacob P} and Cristi{\'a}n Vera-Kellet and Alexander Egeberg and Daniela Armijo and Cristian Pizarro and Tatiana Riveros and Hern{\'a}n Correa and Antonio Guglielmetti and Didaskalu, {Johannes A} and Wu, {Jashin J} and Griffiths, {Christopher E M} and Ricardo Romiti and Julia-Tatjana Maul",

note = "{\textcopyright} 2022 The Authors. Clinical and Experimental Dermatology published by John Wiley & Sons Ltd on behalf of British Association of Dermatologists.",

year = "2022",

month = dec,

doi = "10.1111/ced.15384",

language = "English",

volume = "47",

pages = "2234--2241",

journal = "Clinical and Experimental Dermatology",

issn = "0307-6938",

publisher = "Wiley-Blackwell Publishing Ltd",

number = "12",

}

TY - JOUR

T1 - Comorbidities in Chilean patients with psoriasis

T2 - a Global Healthcare Study on Psoriasis

AU - Valenzuela, Fernando

AU - De La Cruz, Claudia

AU - Lecaros, Cristóbal

AU - Fernández, Javier

AU - Hevia, Gonzalo

AU - Maul, Lara Valeska

AU - Thyssen, Jacob P

AU - Vera-Kellet, Cristián

AU - Egeberg, Alexander

AU - Armijo, Daniela

AU - Pizarro, Cristian

AU - Riveros, Tatiana

AU - Correa, Hernán

AU - Guglielmetti, Antonio

AU - Didaskalu, Johannes A

AU - Wu, Jashin J

AU - Griffiths, Christopher E M

AU - Romiti, Ricardo

AU - Maul, Julia-Tatjana

PY - 2022/12

Y1 - 2022/12

N2 - BACKGROUND: Psoriasis is a chronic inflammatory skin disease associated with several important medical comorbidities. There are scant data available on the comorbidities of patients with psoriasis in South America.AIM: To examine the comorbidity profile of adult patients with psoriasis in Chile and its association with severity of psoriasis.METHODS: This was a multicentre, cross-sectional study involving 16 hospitals and clinics in Chile, which used a 48-item questionnaire to study clinician- and patient-reported outcomes and comorbidities. Inferential analyses were performed by psoriasis severity, using Fisher exact test, Student t-test and multivariable logistic regression.RESULTS: In total, 598 adult patients with psoriasis were included (51.1% male; mean age 49.2 ± 15.1 years); 48.5% mild and 51.4% moderate to severe; Psoriasis Area and Severity Index 11.6 ± 11.5; body surface area 14.7 ± 18.2%. Plaque psoriasis was the most common phenotype (90.2%), followed by guttate (13.4%). Psoriatic arthritis occurred in 27.3% of patients. Comorbidities were reported in 60.2% of all patients with psoriasis. Frequent concomitant diseases were obesity (25.3%), hypertension (24.3%), Type 2 diabetes mellitus (T2DM) (18.7%), dyslipidaemia (17.4%), metabolic syndrome (16.7%) and depression (14.4%). After adjustment, significant associations were found between moderate to severe psoriasis and obesity, T2DM and nonalcoholic fatty liver disease (NAFLD) compared with mild psoriasis.CONCLUSIONS: We report a large study of comorbidities, including depression, dyslipidaemia, T2DM and NAFLD, in people with psoriasis in Chile. The prevalence of comorbidities with psoriasis in Chile appears similar to that found in Western countries, and emphasizes the importance of assessing patients with psoriasis for risk factors for and presence of, comorbid disease in a multidisciplinary setting.

AB - BACKGROUND: Psoriasis is a chronic inflammatory skin disease associated with several important medical comorbidities. There are scant data available on the comorbidities of patients with psoriasis in South America.AIM: To examine the comorbidity profile of adult patients with psoriasis in Chile and its association with severity of psoriasis.METHODS: This was a multicentre, cross-sectional study involving 16 hospitals and clinics in Chile, which used a 48-item questionnaire to study clinician- and patient-reported outcomes and comorbidities. Inferential analyses were performed by psoriasis severity, using Fisher exact test, Student t-test and multivariable logistic regression.RESULTS: In total, 598 adult patients with psoriasis were included (51.1% male; mean age 49.2 ± 15.1 years); 48.5% mild and 51.4% moderate to severe; Psoriasis Area and Severity Index 11.6 ± 11.5; body surface area 14.7 ± 18.2%. Plaque psoriasis was the most common phenotype (90.2%), followed by guttate (13.4%). Psoriatic arthritis occurred in 27.3% of patients. Comorbidities were reported in 60.2% of all patients with psoriasis. Frequent concomitant diseases were obesity (25.3%), hypertension (24.3%), Type 2 diabetes mellitus (T2DM) (18.7%), dyslipidaemia (17.4%), metabolic syndrome (16.7%) and depression (14.4%). After adjustment, significant associations were found between moderate to severe psoriasis and obesity, T2DM and nonalcoholic fatty liver disease (NAFLD) compared with mild psoriasis.CONCLUSIONS: We report a large study of comorbidities, including depression, dyslipidaemia, T2DM and NAFLD, in people with psoriasis in Chile. The prevalence of comorbidities with psoriasis in Chile appears similar to that found in Western countries, and emphasizes the importance of assessing patients with psoriasis for risk factors for and presence of, comorbid disease in a multidisciplinary setting.

KW - Male

KW - Female

KW - Humans

KW - Non-alcoholic Fatty Liver Disease/epidemiology

KW - Chile/epidemiology

KW - Diabetes Mellitus, Type 2/epidemiology

KW - Cross-Sectional Studies

KW - Psoriasis/epidemiology

KW - Comorbidity

KW - Obesity/epidemiology

KW - Dyslipidemias

KW - Delivery of Health Care

UR - http://www.scopus.com/inward/record.url?scp=85141342592&partnerID=8YFLogxK

U2 - 10.1111/ced.15384

DO - 10.1111/ced.15384

M3 - Journal article

C2 - 35988043

VL - 47

SP - 2234

EP - 2241

JO - Clinical and Experimental Dermatology

JF - Clinical and Experimental Dermatology

SN - 0307-6938

IS - 12

ER -

Comorbidities in Chilean patients with psoriasis: a Global Healthcare Study on Psoriasis

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