Common variation at 10p12.31 near MLLT10 influences meningioma risk

Sara E Dobbins; Peter Broderick; Beatrice Melin; Maria Feychting; Christoffer Johansen; Ulrika Andersson; Thomas Brännström; Johannes Schramm; Bianca Olver; Amy Lloyd; Yussanne P Ma; Fay J Hosking; Stefan Lönn; Anders Ahlbom; Roger Henriksson; Minouk J Schoemaker; Sarah J Hepworth; Per Hoffmann; Thomas W Mühleisen; Markus M Nöthen; Susanne Moebus; Lewin Eisele; Michael Kosteljanetz; Kenneth Muir; Anthony Swerdlow; Matthias Simon; Richard S Houlston

doi:10.1038/ng.879

Common variation at 10p12.31 near MLLT10 influences meningioma risk

Sara E Dobbins, Peter Broderick, Beatrice Melin, Maria Feychting, Christoffer Johansen, Ulrika Andersson, Thomas Brännström, Johannes Schramm, Bianca Olver, Amy Lloyd, Yussanne P Ma, Fay J Hosking, Stefan Lönn, Anders Ahlbom, Roger Henriksson, Minouk J Schoemaker, Sarah J Hepworth, Per Hoffmann, Thomas W Mühleisen, Markus M NöthenSusanne Moebus, Lewin Eisele, Michael Kosteljanetz, Kenneth Muir, Anthony Swerdlow, Matthias Simon, Richard S Houlston

Department of Neurosurgery

43 Citations (Scopus)

Abstract

To identify susceptibility loci for meningioma, we conducted a genome-wide association study of 859 affected individuals (cases) and 704 controls with validation in two independent sample sets totaling 774 cases and 1,764 controls. We identified a new susceptibility locus for meningioma at 10p12.31 (MLLT10, rs11012732, odds ratio = 1.46, P(combined) = 1.88 × 10(-14)). This finding advances our understanding of the genetic basis of meningioma development.

Original language	English
Journal	Nature Genetics
Volume	43
Issue number	9
Pages (from-to)	825-7
Number of pages	3
ISSN	1061-4036
DOIs	https://doi.org/10.1038/ng.879
Publication status	Published - 2011

Keywords

Chromosomes, Human, Pair 10
Genetic Loci
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Male
Meningeal Neoplasms
Meningioma
Polymorphism, Genetic
Polymorphism, Single Nucleotide
Risk
Transcription Factors

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10.1038/ng.879

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Dobbins, S. E., Broderick, P., Melin, B., Feychting, M., Johansen, C., Andersson, U., Brännström, T., Schramm, J., Olver, B., Lloyd, A., Ma, Y. P., Hosking, F. J., Lönn, S., Ahlbom, A., Henriksson, R., Schoemaker, M. J., Hepworth, S. J., Hoffmann, P., Mühleisen, T. W., ... Houlston, R. S. (2011). Common variation at 10p12.31 near MLLT10 influences meningioma risk. Nature Genetics, 43(9), 825-7. https://doi.org/10.1038/ng.879

Dobbins, SE, Broderick, P, Melin, B, Feychting, M, Johansen, C, Andersson, U, Brännström, T, Schramm, J, Olver, B, Lloyd, A, Ma, YP, Hosking, FJ, Lönn, S, Ahlbom, A, Henriksson, R, Schoemaker, MJ, Hepworth, SJ, Hoffmann, P, Mühleisen, TW, Nöthen, MM, Moebus, S, Eisele, L, Kosteljanetz, M, Muir, K, Swerdlow, A, Simon, M & Houlston, RS 2011, 'Common variation at 10p12.31 near MLLT10 influences meningioma risk', Nature Genetics, vol. 43, no. 9, pp. 825-7. https://doi.org/10.1038/ng.879

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title = "Common variation at 10p12.31 near MLLT10 influences meningioma risk",

abstract = "To identify susceptibility loci for meningioma, we conducted a genome-wide association study of 859 affected individuals (cases) and 704 controls with validation in two independent sample sets totaling 774 cases and 1,764 controls. We identified a new susceptibility locus for meningioma at 10p12.31 (MLLT10, rs11012732, odds ratio = 1.46, P(combined) = 1.88 × 10(-14)). This finding advances our understanding of the genetic basis of meningioma development.",

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AU - Dobbins, Sara E

AU - Broderick, Peter

AU - Melin, Beatrice

AU - Feychting, Maria

AU - Johansen, Christoffer

AU - Andersson, Ulrika

AU - Brännström, Thomas

AU - Schramm, Johannes

AU - Olver, Bianca

AU - Lloyd, Amy

AU - Ma, Yussanne P

AU - Hosking, Fay J

AU - Lönn, Stefan

AU - Ahlbom, Anders

AU - Henriksson, Roger

AU - Schoemaker, Minouk J

AU - Hepworth, Sarah J

AU - Hoffmann, Per

AU - Mühleisen, Thomas W

AU - Nöthen, Markus M

AU - Moebus, Susanne

AU - Eisele, Lewin

AU - Kosteljanetz, Michael

AU - Muir, Kenneth

AU - Swerdlow, Anthony

AU - Simon, Matthias

AU - Houlston, Richard S

PY - 2011

Y1 - 2011

N2 - To identify susceptibility loci for meningioma, we conducted a genome-wide association study of 859 affected individuals (cases) and 704 controls with validation in two independent sample sets totaling 774 cases and 1,764 controls. We identified a new susceptibility locus for meningioma at 10p12.31 (MLLT10, rs11012732, odds ratio = 1.46, P(combined) = 1.88 × 10(-14)). This finding advances our understanding of the genetic basis of meningioma development.

AB - To identify susceptibility loci for meningioma, we conducted a genome-wide association study of 859 affected individuals (cases) and 704 controls with validation in two independent sample sets totaling 774 cases and 1,764 controls. We identified a new susceptibility locus for meningioma at 10p12.31 (MLLT10, rs11012732, odds ratio = 1.46, P(combined) = 1.88 × 10(-14)). This finding advances our understanding of the genetic basis of meningioma development.

KW - Chromosomes, Human, Pair 10

KW - Genetic Loci

KW - Genetic Predisposition to Disease

KW - Genome-Wide Association Study

KW - Humans

KW - Male

KW - Meningeal Neoplasms

KW - Meningioma

KW - Polymorphism, Genetic

KW - Polymorphism, Single Nucleotide

KW - Risk

KW - Transcription Factors

U2 - 10.1038/ng.879

DO - 10.1038/ng.879

M3 - Journal article

C2 - 21804547

SN - 1061-4036

VL - 43

SP - 825

EP - 827

JO - Nature Genetics

JF - Nature Genetics

IS - 9

ER -

Common variation at 10p12.31 near MLLT10 influences meningioma risk

Abstract

Keywords

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