Common variants of the ACE gene and aneurysmal subarachnoid hemorrhage in a Danish population: a case-control study

Jonathan Myrup; Morten A.  Nielsen; Troels Edsen; Pernille Koefoed; Jacob Bertram Springborg; Finn Borgbjerg Moltke; Henning Laursen; Henning M Bay Nielsen; Niels Vidiendal Olsen

doi:10.1097/ANA.0b013e318225c979

Common variants of the ACE gene and aneurysmal subarachnoid hemorrhage in a Danish population: a case-control study

Jonathan Myrup, Morten A. Nielsen, Troels Edsen, Pernille Koefoed, Jacob Bertram Springborg, Finn Borgbjerg Moltke, Henning Laursen, Henning M Bay Nielsen, Niels Vidiendal Olsen

13 Citations (Scopus)

Abstract

The intron 16 insertion/deletion (I/D) polymorphism in the angiotensin-converting enzyme (ACE) gene has been associated with rupture of intracranial aneurysms, but the effect of haplotypes within ACE has not been studied. This study investigated whether ACE haplotypes including the I/D polymorphism are associated with aneurysmal subarachnoid hemorrhage.

Original language	English
Journal	Journal of Neurosurgical Anesthesiology
Volume	23
Issue number	4
Pages (from-to)	304-9
Number of pages	6
ISSN	0898-4921
DOIs	https://doi.org/10.1097/ANA.0b013e318225c979
Publication status	Published - 2011

Keywords

Adolescent
Adult
Aged
Alleles
Case-Control Studies
DNA
Denmark
Female
Gene Frequency
Genetic Predisposition to Disease
Genotype
Haplotypes
Humans
Male
Middle Aged
Peptidyl-Dipeptidase A
Polymorphism, Single Nucleotide
Subarachnoid Hemorrhage
Young Adult

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10.1097/ANA.0b013e318225c979

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title = "Common variants of the ACE gene and aneurysmal subarachnoid hemorrhage in a Danish population: a case-control study",

abstract = "The intron 16 insertion/deletion (I/D) polymorphism in the angiotensin-converting enzyme (ACE) gene has been associated with rupture of intracranial aneurysms, but the effect of haplotypes within ACE has not been studied. This study investigated whether ACE haplotypes including the I/D polymorphism are associated with aneurysmal subarachnoid hemorrhage.",

keywords = "Adolescent, Adult, Aged, Alleles, Case-Control Studies, DNA, Denmark, Female, Gene Frequency, Genetic Predisposition to Disease, Genotype, Haplotypes, Humans, Male, Middle Aged, Peptidyl-Dipeptidase A, Polymorphism, Single Nucleotide, Subarachnoid Hemorrhage, Young Adult",

author = "Jonathan Myrup and Nielsen, {Morten A.} and Troels Edsen and Pernille Koefoed and Springborg, {Jacob Bertram} and Moltke, {Finn Borgbjerg} and Henning Laursen and Nielsen, {Henning M Bay} and Olsen, {Niels Vidiendal}",

year = "2011",

doi = "10.1097/ANA.0b013e318225c979",

language = "English",

volume = "23",

pages = "304--9",

journal = "Journal of Neurosurgical Anesthesiology",

issn = "0898-4921",

publisher = "Lippincott Williams & Wilkins",

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TY - JOUR

T1 - Common variants of the ACE gene and aneurysmal subarachnoid hemorrhage in a Danish population: a case-control study

AU - Myrup, Jonathan

AU - Nielsen, Morten A.

AU - Edsen, Troels

AU - Koefoed, Pernille

AU - Springborg, Jacob Bertram

AU - Moltke, Finn Borgbjerg

AU - Laursen, Henning

AU - Nielsen, Henning M Bay

AU - Olsen, Niels Vidiendal

PY - 2011

Y1 - 2011

N2 - The intron 16 insertion/deletion (I/D) polymorphism in the angiotensin-converting enzyme (ACE) gene has been associated with rupture of intracranial aneurysms, but the effect of haplotypes within ACE has not been studied. This study investigated whether ACE haplotypes including the I/D polymorphism are associated with aneurysmal subarachnoid hemorrhage.

AB - The intron 16 insertion/deletion (I/D) polymorphism in the angiotensin-converting enzyme (ACE) gene has been associated with rupture of intracranial aneurysms, but the effect of haplotypes within ACE has not been studied. This study investigated whether ACE haplotypes including the I/D polymorphism are associated with aneurysmal subarachnoid hemorrhage.

KW - Adolescent

KW - Adult

KW - Aged

KW - Alleles

KW - Case-Control Studies

KW - DNA

KW - Denmark

KW - Female

KW - Gene Frequency

KW - Genetic Predisposition to Disease

KW - Genotype

KW - Haplotypes

KW - Humans

KW - Male

KW - Middle Aged

KW - Peptidyl-Dipeptidase A

KW - Polymorphism, Single Nucleotide

KW - Subarachnoid Hemorrhage

KW - Young Adult

U2 - 10.1097/ANA.0b013e318225c979

DO - 10.1097/ANA.0b013e318225c979

M3 - Journal article

C2 - 21709586

VL - 23

SP - 304

EP - 309

JO - Journal of Neurosurgical Anesthesiology

JF - Journal of Neurosurgical Anesthesiology

SN - 0898-4921

IS - 4

ER -

Common variants of the ACE gene and aneurysmal subarachnoid hemorrhage in a Danish population: a case-control study

Abstract

Keywords

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