Harvard
Gormley, P, Kurki, MI, Hiekkala, ME, Veerapen, K, Häppölä, P, Mitchell, AA, Lal, D, Palta, P, Surakka, I, Kaunisto, MA, Hämäläinen, E, Vepsäläinen, S, Havanka, H, Harno, H, Ilmavirta, M, Nissilä, M, Säkö, E, Sumelahti, ML, Liukkonen, J, Sillanpää, M, Metsähonkala, L, Koskinen, S, Lehtimäki, T, Raitakari, O, Männikkö, M, Ran, C, Belin, AC, Jousilahti, P, Anttila, V, Salomaa, V, Artto, V, Färkkilä, M, Agee, M, Alipanahi, B, Auton, A, Bell, RK, Bryc, K, Elson, SL, Fontanillas, P, Furlotte, NA, Huber, KE, Kleinman, A, Litterman, NK, McCreight, JC, McIntyre, MH
, Christensen, AF, Esserlind, AL, Hansen, TF, Ingason, A, Olesen, J, 23andMe Research Team & International Headache Genetics Consortium (IHGC) 2018, '
Common Variant Burden Contributes to the Familial Aggregation of Migraine in 1,589 Families'
Neuron, vol. 98, no. 4, pp. 743-753.e4.
https://doi.org/10.1016/j.neuron.2018.04.014APA
Gormley, P., Kurki, M. I., Hiekkala, M. E., Veerapen, K., Häppölä, P., Mitchell, A. A., ... International Headache Genetics Consortium (IHGC) (2018).
Common Variant Burden Contributes to the Familial Aggregation of Migraine in 1,589 Families.
Neuron,
98(4), 743-753.e4.
https://doi.org/10.1016/j.neuron.2018.04.014CBE
Gormley P, Kurki MI, Hiekkala ME, Veerapen K, Häppölä P, Mitchell AA, Lal D, Palta P, Surakka I, Kaunisto MA, Hämäläinen E, Vepsäläinen S, Havanka H, Harno H, Ilmavirta M, Nissilä M, Säkö E, Sumelahti ML, Liukkonen J, Sillanpää M, Metsähonkala L, Koskinen S, Lehtimäki T, Raitakari O, Männikkö M, Ran C, Belin AC, Jousilahti P, Anttila V, Salomaa V, Artto V, Färkkilä M, Agee M, Alipanahi B, Auton A, Bell RK, Bryc K, Elson SL, Fontanillas P, Furlotte NA, Huber KE, Kleinman A, Litterman NK, McCreight JC, McIntyre MH
, Christensen AF, Esserlind AL, Hansen TF, Ingason A, Olesen J, 23andMe Research Team, International Headache Genetics Consortium (IHGC). 2018.
Common Variant Burden Contributes to the Familial Aggregation of Migraine in 1,589 Families.
Neuron. 98(4):743-753.e4.
https://doi.org/10.1016/j.neuron.2018.04.014MLA
Vancouver
Author
Gormley, Padhraig ; Kurki, Mitja I. ; Hiekkala, Marjo Eveliina ; Veerapen, Kumar ; Häppölä, Paavo ; Mitchell, Adele A. ; Lal, Dennis ; Palta, Priit ; Surakka, Ida ; Kaunisto, Mari Anneli ; Hämäläinen, Eija ; Vepsäläinen, Salli ; Havanka, Hannele ; Harno, Hanna ; Ilmavirta, Matti ; Nissilä, Markku ; Säkö, Erkki ; Sumelahti, Marja Liisa ; Liukkonen, Jarmo ; Sillanpää, Matti ; Metsähonkala, Liisa ; Koskinen, Seppo ; Lehtimäki, Terho ; Raitakari, Olli ; Männikkö, Minna ; Ran, Caroline ; Belin, Andrea Carmine ; Jousilahti, Pekka ; Anttila, Verneri ; Salomaa, Veikko ; Artto, Ville ; Färkkilä, Markus ; Agee, Michelle ; Alipanahi, Babak ; Auton, Adam ; Bell, Robert K. ; Bryc, Katarzyna ; Elson, Sarah L. ; Fontanillas, Pierre ; Furlotte, Nicholas A. ; Huber, Karen E. ; Kleinman, Aaron ; Litterman, Nadia K. ; McCreight, Jennifer C. ; McIntyre, Matthew H.
; Christensen, Anne Francke ; Esserlind, Ann Louise ; Hansen, Thomas Folkmann ; Ingason, Andres ; Olesen, Jes ; 23andMe Research Team ; International Headache Genetics Consortium (IHGC). /
Common Variant Burden Contributes to the Familial Aggregation of Migraine in 1,589 Families. In:
Neuron. 2018 ; Vol. 98, No. 4. pp. 743-753.e4.
Bibtex
@article{a6e9975e41314fd0addf8fa094a4beb3,
title = "Common Variant Burden Contributes to the Familial Aggregation of Migraine in 1,589 Families",
abstract = "Complex traits, including migraine, often aggregate in families, but the underlying genetic architecture behind this is not well understood. The aggregation could be explained by rare, penetrant variants that segregate according to Mendelian inheritance or by the sufficient polygenic accumulation of common variants, each with an individually small effect, or a combination of the two hypotheses. In 8,319 individuals across 1,589 migraine families, we calculated migraine polygenic risk scores (PRS) and found a significantly higher common variant burden in familial cases (n = 5,317, OR = 1.76, 95{\%} CI = 1.71–1.81, p = 1.7 × 10−109) compared to population cases from the FINRISK cohort (n = 1,101, OR = 1.32, 95{\%} CI = 1.25–1.38, p = 7.2 × 10−17). The PRS explained 1.6{\%} of the phenotypic variance in the population cases and 3.5{\%} in the familial cases (including 2.9{\%} for migraine without aura, 5.5{\%} for migraine with typical aura, and 8.2{\%} for hemiplegic migraine). The results demonstrate a significant contribution of common polygenic variation to the familial aggregation of migraine. Gormley et al. use polygenic risk scores to show that common variation, captured by genome-wide association studies, in combination contributes to the aggregation of migraine in families. The results may have similar implications for other complex traits in general.",
keywords = "disease aggregation, familial aggregation, families, genome-wide association study, GWAS, hemiplegic migraine, migraine, migraine with aura, polygenic risk score, PRS",
author = "Padhraig Gormley and Kurki, {Mitja I.} and Hiekkala, {Marjo Eveliina} and Kumar Veerapen and Paavo H{\"a}pp{\"o}l{\"a} and Mitchell, {Adele A.} and Dennis Lal and Priit Palta and Ida Surakka and Kaunisto, {Mari Anneli} and Eija H{\"a}m{\"a}l{\"a}inen and Salli Veps{\"a}l{\"a}inen and Hannele Havanka and Hanna Harno and Matti Ilmavirta and Markku Nissil{\"a} and Erkki S{\"a}k{\"o} and Sumelahti, {Marja Liisa} and Jarmo Liukkonen and Matti Sillanp{\"a}{\"a} and Liisa Mets{\"a}honkala and Seppo Koskinen and Terho Lehtim{\"a}ki and Olli Raitakari and Minna M{\"a}nnikk{\"o} and Caroline Ran and Belin, {Andrea Carmine} and Pekka Jousilahti and Verneri Anttila and Veikko Salomaa and Ville Artto and Markus F{\"a}rkkil{\"a} and Michelle Agee and Babak Alipanahi and Adam Auton and Bell, {Robert K.} and Katarzyna Bryc and Elson, {Sarah L.} and Pierre Fontanillas and Furlotte, {Nicholas A.} and Huber, {Karen E.} and Aaron Kleinman and Litterman, {Nadia K.} and McCreight, {Jennifer C.} and McIntyre, {Matthew H.} and Christensen, {Anne Francke} and Esserlind, {Ann Louise} and Hansen, {Thomas Folkmann} and Andres Ingason and Jes Olesen and {23andMe Research Team} and {International Headache Genetics Consortium (IHGC)}",
year = "2018",
month = "5",
day = "16",
doi = "10.1016/j.neuron.2018.04.014",
language = "English",
volume = "98",
pages = "743--753.e4",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "4",
}
RIS
TY - JOUR
T1 - Common Variant Burden Contributes to the Familial Aggregation of Migraine in 1,589 Families
AU - Gormley, Padhraig
AU - Kurki, Mitja I.
AU - Hiekkala, Marjo Eveliina
AU - Veerapen, Kumar
AU - Häppölä, Paavo
AU - Mitchell, Adele A.
AU - Lal, Dennis
AU - Palta, Priit
AU - Surakka, Ida
AU - Kaunisto, Mari Anneli
AU - Hämäläinen, Eija
AU - Vepsäläinen, Salli
AU - Havanka, Hannele
AU - Harno, Hanna
AU - Ilmavirta, Matti
AU - Nissilä, Markku
AU - Säkö, Erkki
AU - Sumelahti, Marja Liisa
AU - Liukkonen, Jarmo
AU - Sillanpää, Matti
AU - Metsähonkala, Liisa
AU - Koskinen, Seppo
AU - Lehtimäki, Terho
AU - Raitakari, Olli
AU - Männikkö, Minna
AU - Ran, Caroline
AU - Belin, Andrea Carmine
AU - Jousilahti, Pekka
AU - Anttila, Verneri
AU - Salomaa, Veikko
AU - Artto, Ville
AU - Färkkilä, Markus
AU - Agee, Michelle
AU - Alipanahi, Babak
AU - Auton, Adam
AU - Bell, Robert K.
AU - Bryc, Katarzyna
AU - Elson, Sarah L.
AU - Fontanillas, Pierre
AU - Furlotte, Nicholas A.
AU - Huber, Karen E.
AU - Kleinman, Aaron
AU - Litterman, Nadia K.
AU - McCreight, Jennifer C.
AU - McIntyre, Matthew H.
AU - Christensen, Anne Francke
AU - Esserlind, Ann Louise
AU - Hansen, Thomas Folkmann
AU - Ingason, Andres
AU - Olesen, Jes
AU - 23andMe Research Team
AU - International Headache Genetics Consortium (IHGC)
PY - 2018/5/16
Y1 - 2018/5/16
N2 - Complex traits, including migraine, often aggregate in families, but the underlying genetic architecture behind this is not well understood. The aggregation could be explained by rare, penetrant variants that segregate according to Mendelian inheritance or by the sufficient polygenic accumulation of common variants, each with an individually small effect, or a combination of the two hypotheses. In 8,319 individuals across 1,589 migraine families, we calculated migraine polygenic risk scores (PRS) and found a significantly higher common variant burden in familial cases (n = 5,317, OR = 1.76, 95% CI = 1.71–1.81, p = 1.7 × 10−109) compared to population cases from the FINRISK cohort (n = 1,101, OR = 1.32, 95% CI = 1.25–1.38, p = 7.2 × 10−17). The PRS explained 1.6% of the phenotypic variance in the population cases and 3.5% in the familial cases (including 2.9% for migraine without aura, 5.5% for migraine with typical aura, and 8.2% for hemiplegic migraine). The results demonstrate a significant contribution of common polygenic variation to the familial aggregation of migraine. Gormley et al. use polygenic risk scores to show that common variation, captured by genome-wide association studies, in combination contributes to the aggregation of migraine in families. The results may have similar implications for other complex traits in general.
AB - Complex traits, including migraine, often aggregate in families, but the underlying genetic architecture behind this is not well understood. The aggregation could be explained by rare, penetrant variants that segregate according to Mendelian inheritance or by the sufficient polygenic accumulation of common variants, each with an individually small effect, or a combination of the two hypotheses. In 8,319 individuals across 1,589 migraine families, we calculated migraine polygenic risk scores (PRS) and found a significantly higher common variant burden in familial cases (n = 5,317, OR = 1.76, 95% CI = 1.71–1.81, p = 1.7 × 10−109) compared to population cases from the FINRISK cohort (n = 1,101, OR = 1.32, 95% CI = 1.25–1.38, p = 7.2 × 10−17). The PRS explained 1.6% of the phenotypic variance in the population cases and 3.5% in the familial cases (including 2.9% for migraine without aura, 5.5% for migraine with typical aura, and 8.2% for hemiplegic migraine). The results demonstrate a significant contribution of common polygenic variation to the familial aggregation of migraine. Gormley et al. use polygenic risk scores to show that common variation, captured by genome-wide association studies, in combination contributes to the aggregation of migraine in families. The results may have similar implications for other complex traits in general.
KW - disease aggregation
KW - familial aggregation
KW - families
KW - genome-wide association study
KW - GWAS
KW - hemiplegic migraine
KW - migraine
KW - migraine with aura
KW - polygenic risk score
KW - PRS
UR - http://www.scopus.com/inward/record.url?scp=85046116467&partnerID=8YFLogxK
U2 - 10.1016/j.neuron.2018.04.014
DO - 10.1016/j.neuron.2018.04.014
M3 - Journal article
VL - 98
SP - 743-753.e4
JO - Neuron
JF - Neuron
SN - 0896-6273
IS - 4
ER -
