Common TNF-alpha, IL-1 beta, PAI-1, uPA, CD14 and TLR4 polymorphisms are not associated with disease severity or outcome from Gram negative sepsis

Kristine Marie Jessen, Sarah Bjerre Lindboe, Anncatrine Luisa Petersen, Jesper Eugen-Olsen, Thomas Benfield

59 Citations (Scopus)

Abstract

Several studies have investigated single nucleotide polymorphisms (SNPs) in candidate genes associated with sepsis and septic shock with conflicting results. Only few studies have combined the analysis of multiple SNPs in the same population.
Original languageEnglish
JournalBMC Infectious Disease
Volume18
Issue number7
Pages (from-to)108
DOIs
Publication statusPublished - 2007

Keywords

  • Aged
  • Aged, 80 and over
  • Antigens, CD14
  • Bacteremia
  • Cytokines
  • Female
  • Gram-Negative Bacteria
  • Gram-Negative Bacterial Infections
  • Humans
  • Interleukin-1beta
  • Male
  • Middle Aged
  • Plasminogen Activator Inhibitor 1
  • Polymorphism, Single Nucleotide
  • Receptors, Immunologic
  • Severity of Illness Index
  • Toll-Like Receptor 4
  • Tumor Necrosis Factor-alpha
  • Urokinase-Type Plasminogen Activator

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