Common polymorphisms in KCNJ5 [corrected] are associated with early-onset lone atrial fibrillation in Caucasians

Javad Jabbari; Morten S Olesen; Anders G Holst; Jonas B Nielsen; Stig Haunso; Jesper H Svendsen

doi:10.1159/000323840

Common polymorphisms in KCNJ5 [corrected] are associated with early-onset lone atrial fibrillation in Caucasians

Javad Jabbari, Morten S Olesen, Anders G Holst, Jonas B Nielsen, Stig Haunso, Jesper H Svendsen

24 Citations (Scopus)

Abstract

The aim of this study was to screen lone atrial fibrillation (AF) patients for mutations in the genes KCNJ2, KCNJ3 and KCNJ5, all encoding potassium channels. Furthermore, we wanted to replicate the prior association of two single-nucleotide polymorphisms (SNPs) in KCNJ5, C171T (rs6590357) and G810T (rs7118824), with lone AF in Han Chinese.

Original language	English
Journal	Cardiology
Volume	118
Issue number	2
Pages (from-to)	116-20
Number of pages	5
ISSN	0008-6312
DOIs	https://doi.org/10.1159/000323840
Publication status	Published - 2011

Keywords

Adult
Aged
Atrial Fibrillation
Case-Control Studies
DNA Primers
Denmark
European Continental Ancestry Group
Female
G Protein-Coupled Inwardly-Rectifying Potassium Channels
Genotype
Humans
Logistic Models
Male
Middle Aged
Mutation
Polymerase Chain Reaction
Polymorphism, Single Nucleotide
Potassium Channels, Inwardly Rectifying
Young Adult

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title = "Common polymorphisms in KCNJ5 [corrected] are associated with early-onset lone atrial fibrillation in Caucasians",

abstract = "The aim of this study was to screen lone atrial fibrillation (AF) patients for mutations in the genes KCNJ2, KCNJ3 and KCNJ5, all encoding potassium channels. Furthermore, we wanted to replicate the prior association of two single-nucleotide polymorphisms (SNPs) in KCNJ5, C171T (rs6590357) and G810T (rs7118824), with lone AF in Han Chinese.",

keywords = "Adult, Aged, Atrial Fibrillation, Case-Control Studies, DNA Primers, Denmark, European Continental Ancestry Group, Female, G Protein-Coupled Inwardly-Rectifying Potassium Channels, Genotype, Humans, Logistic Models, Male, Middle Aged, Mutation, Polymerase Chain Reaction, Polymorphism, Single Nucleotide, Potassium Channels, Inwardly Rectifying, Young Adult",

author = "Javad Jabbari and Olesen, \{Morten S\} and Holst, \{Anders G\} and Nielsen, \{Jonas B\} and Stig Haunso and Svendsen, \{Jesper H\}",

note = "Copyright {\textcopyright} 2011 S. Karger AG, Basel.",

year = "2011",

doi = "10.1159/000323840",

language = "English",

volume = "118",

pages = "116--20",

journal = "Cardiology",

issn = "0008-6312",

publisher = "S. Karger AG",

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T1 - Common polymorphisms in KCNJ5 [corrected] are associated with early-onset lone atrial fibrillation in Caucasians

AU - Jabbari, Javad

AU - Olesen, Morten S

AU - Holst, Anders G

AU - Nielsen, Jonas B

AU - Haunso, Stig

AU - Svendsen, Jesper H

PY - 2011

Y1 - 2011

N2 - The aim of this study was to screen lone atrial fibrillation (AF) patients for mutations in the genes KCNJ2, KCNJ3 and KCNJ5, all encoding potassium channels. Furthermore, we wanted to replicate the prior association of two single-nucleotide polymorphisms (SNPs) in KCNJ5, C171T (rs6590357) and G810T (rs7118824), with lone AF in Han Chinese.

AB - The aim of this study was to screen lone atrial fibrillation (AF) patients for mutations in the genes KCNJ2, KCNJ3 and KCNJ5, all encoding potassium channels. Furthermore, we wanted to replicate the prior association of two single-nucleotide polymorphisms (SNPs) in KCNJ5, C171T (rs6590357) and G810T (rs7118824), with lone AF in Han Chinese.

KW - Adult

KW - Aged

KW - Atrial Fibrillation

KW - Case-Control Studies

KW - DNA Primers

KW - Denmark

KW - European Continental Ancestry Group

KW - Female

KW - G Protein-Coupled Inwardly-Rectifying Potassium Channels

KW - Genotype

KW - Humans

KW - Logistic Models

KW - Male

KW - Middle Aged

KW - Mutation

KW - Polymerase Chain Reaction

KW - Polymorphism, Single Nucleotide

KW - Potassium Channels, Inwardly Rectifying

KW - Young Adult

UR - https://www.scopus.com/pages/publications/79955688385

U2 - 10.1159/000323840

DO - 10.1159/000323840

M3 - Journal article

C2 - 21555883

SN - 0008-6312

VL - 118

SP - 116

EP - 120

JO - Cardiology

JF - Cardiology

IS - 2

ER -

Common polymorphisms in KCNJ5 [corrected] are associated with early-onset lone atrial fibrillation in Caucasians

Abstract

Keywords

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