Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Common HTR2A variants and 5-HTTLPR are not associated with human in vivo serotonin 2A receptor levels

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Multi-dimensional predictions of psychotic symptoms via machine learning

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Generalizability of machine learning for classification of schizophrenia based on resting-state functional MRI data

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Widespread higher fractional anisotropy associates to better cognitive functions in individuals at ultra-high risk for psychosis

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Classification of social anhedonia using temporal and spatial network features from a social cognition fMRI task

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Prevalence of cognitive impairment and its relation to mental health in Danish lymphoma survivors

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. A high-resolution in vivo atlas of the human brain's benzodiazepine binding site of GABAA receptors

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Nondisplaceable Binding Is a Potential Confounding Factor in 11C-PBR28 Translocator Protein PET Studies

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

The serotonin 2A receptor (5-HT2AR) is implicated in the pathophysiology and treatment of various psychiatric disorders. [18 F]altanserin and [11 C]Cimbi-36 positron emission tomography (PET) allow for high-resolution imaging of 5-HT2AR in the living human brain. Cerebral 5-HT2AR binding is strongly genetically determined, though the impact of specific variants is poorly understood. Candidate gene studies suggest that HTR2A single nucleotide polymorphisms including rs6311/rs6313, rs6314, and rs7997012 may influence risk for psychiatric disorders and mediate treatment response. Although known to impact in vitro expression of 5-HT2AR or other serotonin (5-HT) proteins, their effect on human in vivo brain 5-HT2AR binding has as of yet been insufficiently studied. We thus assessed the extent to which these variants and the commonly studied 5-HTTLPR predict neocortex in vivo 5-HT2AR binding in healthy adult humans. We used linear regression analyses and likelihood ratio tests in 197 subjects scanned with [18 F]altanserin or [11 C]Cimbi-36 PET. Although we observed genotype group differences in 5-HT2AR binding of up to ~10%, no genetic variants were statistically significantly predictive of 5-HT2AR binding in what is the largest human in vivo 5-HT2AR imaging genetics study to date. Thus, in vitro and post mortem results suggesting effects on 5-HT2AR expression did not carry over to the in vivo setting. To any extent these variants might affect clinical risk, our findings do not support that 5-HT2AR binding mediates such effects. Our observations indicate that these individual variants do not significantly contribute to genetic load on human in vivo 5-HT2AR binding.

Original languageEnglish
JournalHuman Brain Mapping
Volume41
Issue number16
Pages (from-to)4518-4528
Number of pages11
ISSN1065-9471
DOIs
Publication statusPublished - Nov 2020

ID: 62072192