Common and rare alleles in apolipoprotein B contribute to plasma levels of low-density lipoprotein cholesterol in the general population

Marianne Benn; Maria Charlotte Aslaug Stene; Børge G Nordestgaard; Gorm B Jensen; Rolf Steffensen; Anne Tybjaerg-Hansen

doi:10.1210/jc.2007-1365

Common and rare alleles in apolipoprotein B contribute to plasma levels of low-density lipoprotein cholesterol in the general population

Marianne Benn, Maria Charlotte Aslaug Stene, Børge G Nordestgaard, Gorm B Jensen, Rolf Steffensen, Anne Tybjaerg-Hansen

33 Citations (Scopus)

Abstract

We have previously shown that rare mutations in the apolipoprotein B gene (APOB) may result in not only severe hypercholesterolemia and ischemic heart disease but also hypocholesterolemia. Despite this, common single-nucleotide polymorphisms (SNPs) in APOB have not convincingly been demonstrated to affect low-density lipoprotein (LDL) cholesterol levels.

Original language	English
Journal	Journal of Clinical Endocrinology and Metabolism
Volume	93
Issue number	3
Pages (from-to)	1038-45
Number of pages	8
ISSN	0021-972X
DOIs	https://doi.org/10.1210/jc.2007-1365
Publication status	Published - 2008

Keywords

Adult
Aged
Aged, 80 and over
Alleles
Apolipoproteins B
Cholesterol, LDL
Female
Humans
Linkage Disequilibrium
Male
Middle Aged
Myocardial Infarction
Myocardial Ischemia
Polymorphism, Single Nucleotide
Prospective Studies

Access to Document

10.1210/jc.2007-1365

Cite this

Common and rare alleles in apolipoprotein B contribute to plasma levels of low-density lipoprotein cholesterol in the general population. / Benn, Marianne; Stene, Maria Charlotte Aslaug; Nordestgaard, Børge G et al.
In: Journal of Clinical Endocrinology and Metabolism, Vol. 93, No. 3, 2008, p. 1038-45.

Research output: Contribution to journal › Journal article › Research › peer-review

@article{8fc6445f137441d796ce891e5f019da9,

title = "Common and rare alleles in apolipoprotein B contribute to plasma levels of low-density lipoprotein cholesterol in the general population",

abstract = "We have previously shown that rare mutations in the apolipoprotein B gene (APOB) may result in not only severe hypercholesterolemia and ischemic heart disease but also hypocholesterolemia. Despite this, common single-nucleotide polymorphisms (SNPs) in APOB have not convincingly been demonstrated to affect low-density lipoprotein (LDL) cholesterol levels.",

keywords = "Adult, Aged, Aged, 80 and over, Alleles, Apolipoproteins B, Cholesterol, LDL, Female, Humans, Linkage Disequilibrium, Male, Middle Aged, Myocardial Infarction, Myocardial Ischemia, Polymorphism, Single Nucleotide, Prospective Studies",

author = "Marianne Benn and Stene, {Maria Charlotte Aslaug} and Nordestgaard, {B{\o}rge G} and Jensen, {Gorm B} and Rolf Steffensen and Anne Tybjaerg-Hansen",

year = "2008",

doi = "10.1210/jc.2007-1365",

language = "English",

volume = "93",

pages = "1038--45",

journal = "Journal of Clinical Endocrinology and Metabolism",

issn = "0021-972X",

publisher = "The/Endocrine Society",

number = "3",

}

TY - JOUR

T1 - Common and rare alleles in apolipoprotein B contribute to plasma levels of low-density lipoprotein cholesterol in the general population

AU - Benn, Marianne

AU - Stene, Maria Charlotte Aslaug

AU - Nordestgaard, Børge G

AU - Jensen, Gorm B

AU - Steffensen, Rolf

AU - Tybjaerg-Hansen, Anne

PY - 2008

Y1 - 2008

N2 - We have previously shown that rare mutations in the apolipoprotein B gene (APOB) may result in not only severe hypercholesterolemia and ischemic heart disease but also hypocholesterolemia. Despite this, common single-nucleotide polymorphisms (SNPs) in APOB have not convincingly been demonstrated to affect low-density lipoprotein (LDL) cholesterol levels.

AB - We have previously shown that rare mutations in the apolipoprotein B gene (APOB) may result in not only severe hypercholesterolemia and ischemic heart disease but also hypocholesterolemia. Despite this, common single-nucleotide polymorphisms (SNPs) in APOB have not convincingly been demonstrated to affect low-density lipoprotein (LDL) cholesterol levels.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Alleles

KW - Apolipoproteins B

KW - Cholesterol, LDL

KW - Female

KW - Humans

KW - Linkage Disequilibrium

KW - Male

KW - Middle Aged

KW - Myocardial Infarction

KW - Myocardial Ischemia

KW - Polymorphism, Single Nucleotide

KW - Prospective Studies

U2 - 10.1210/jc.2007-1365

DO - 10.1210/jc.2007-1365

M3 - Journal article

C2 - 18160469

SN - 0021-972X

VL - 93

SP - 1038

EP - 1045

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

IS - 3

ER -

Common and rare alleles in apolipoprotein B contribute to plasma levels of low-density lipoprotein cholesterol in the general population

Abstract

Keywords

Access to Document

Fingerprint

Cite this