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Combinations of Genetic Variants Occurring Exclusively in Patients

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  1. Combinations of SNP genotypes from the Wellcome Trust Case Control Study of bipolar patients

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  2. Combinations of genetic variants associated with bipolar disorder

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  3. Combinations of Genetic Data Present in Bipolar Patients, but Absent in Control Persons

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  4. Connection between Genetic and Clinical Data in Bipolar Disorder

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  5. Genetics of complex diseases: variations on a theme

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In studies of polygenic disorders, scanning the genetic variants can be used to identify variant combinations. Combinations that are exclusively found in patients can be separated from those combinations occurring in control persons. Statistical analyses can be performed to determine whether the combinations that occur exclusively among patients are significantly associated with the investigated disorder. This research strategy has been applied in materials from various polygenic disorders, identifying clusters of patient-specific genetic variant combinations that are significant associated with the investigated disorders. Combinations from these clusters are found in the genomes of up to 55% of investigated patients, and are not present in the genomes of any control persons.

Original languageEnglish
JournalComputational and Structural Biotechnology Journal
Volume15
Pages (from-to)286-289
Number of pages4
ISSN2001-0370
DOIs
Publication statusPublished - 2017

    Research areas

  • Journal Article, Review

ID: 52610732