Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Colonic transit time is related to bacterial metabolism and mucosal turnover in the gut

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Transcriptional interactions suggest niche segregation among microorganisms in the human gut

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Evolutionary insight from whole-genome sequencing of Pseudomonas aeruginosa from cystic fibrosis patients

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Are biofilms responsible for the adverse effects experienced following soft-tissue fillers?

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Targeting quorum sensing in Pseudomonas aeruginosa biofilms: current and emerging inhibitors

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Future challenges and treatment of Staphylococcus aureus bacteremia with emphasis on MRSA

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Haploinsufficiency of ARHGAP42 is associated with hypertension

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Genetic Determinants of Weight Loss After Bariatric Surgery

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Metformin-induced changes of the gut microbiota in healthy young men: results of a non-blinded, one-armed intervention study

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Henrik M Roager
  • Lea B S Hansen
  • Martin I Bahl
  • Henrik L Frandsen
  • Vera Carvalho
  • Rikke J Gøbel
  • Marlene D Dalgaard
  • Damian R Plichta
  • Morten H Sparholt
  • Henrik Vestergaard
  • Torben Hansen
  • Thomas Sicheritz-Pontén
  • H Bjørn Nielsen
  • Oluf Pedersen
  • Lotte Lauritzen
  • Mette Kristensen
  • Ramneek Gupta
  • Tine R Licht
View graph of relations

Little is known about how colonic transit time relates to human colonic metabolism and its importance for host health, although a firm stool consistency, a proxy for a long colonic transit time, has recently been positively associated with gut microbial richness. Here, we show that colonic transit time in humans, assessed using radio-opaque markers, is associated with overall gut microbial composition, diversity and metabolism. We find that a long colonic transit time associates with high microbial richness and is accompanied by a shift in colonic metabolism from carbohydrate fermentation to protein catabolism as reflected by higher urinary levels of potentially deleterious protein-derived metabolites. Additionally, shorter colonic transit time correlates with metabolites possibly reflecting increased renewal of the colonic mucosa. Together, this suggests that a high gut microbial richness does not per se imply a healthy gut microbial ecosystem and points at colonic transit time as a highly important factor to consider in microbiome and metabolomics studies.

Original languageEnglish
JournalFuture Microbiology
Volume1
Issue number9
Pages (from-to)16093
ISSN1746-0913
DOIs
Publication statusPublished - 27 Jun 2016

    Research areas

  • Journal Article

ID: 51900648