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Co-localisation of the Kir6.2/SUR1 channel complex with glucagon-like peptide-1 and glucose-dependent insulinotrophic polypeptide expression in human ileal cells and implications for glycaemic control in new onset type 1 diabetes

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@article{4f71c176b8234b4594f1fda105be9004,
title = "Co-localisation of the Kir6.2/SUR1 channel complex with glucagon-like peptide-1 and glucose-dependent insulinotrophic polypeptide expression in human ileal cells and implications for glycaemic control in new onset type 1 diabetes",
abstract = "The ATP-dependent K+-channel (K(ATP)) is critical for glucose sensing and normal glucagon and insulin secretion from pancreatic endocrine alpha- and beta-cells. Gastrointestinal endocrine L- and K-cells are also glucose-sensing cells secreting glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotrophic polypeptide (GIP) respectively. The aims of this study were to 1) investigate the expression and co-localisation of the K(ATP) channel subunits, Kir6.2 and SUR1, in human L- and K-cells and 2) investigate if a common hyperactive variant of the Kir6.2 subunit, Glu23Lys, exerts a functional impact on glucose-sensing tissues in vivo that may affect the overall glycaemic control in children with new-onset type 1 diabetes.",
keywords = "ATP-Binding Cassette Transporters, Adolescent, Blotting, Western, C-Peptide, Child, Diabetes Mellitus, Type 1, Eating, Female, Gastric Inhibitory Polypeptide, Genotype, Glucagon, Glucagon-Like Peptide 1, Hemoglobin A, Glycosylated, Humans, Hyperglycemia, Hypoglycemic Agents, Ileum, Immunohistochemistry, Insulin, Islets of Langerhans, Male, Polymorphism, Restriction Fragment Length, Potassium Channels, Potassium Channels, Inwardly Rectifying, Receptors, Drug",
author = "Nielsen, {Lotte B} and Ploug, {Kenneth B} and Peter Swift and Cathrine {\O}rskov and Inger Jansen-Olesen and Francesco Chiarelli and Holst, {Jens Juul} and Philip Hougaard and Sven P{\"o}rksen and Reinhard Holl and {de Beaufort}, Carine and Steen Gammeltoft and Patrik Rorsman and Mortensen, {Henrik B} and Lars Hansen and {Hvid{\o}re Study Group}",
year = "2007",
doi = "10.1530/EJE-06-0756",
language = "English",
volume = "156",
pages = "663--71",
journal = "European Journal of Endocrinology",
issn = "0804-4643",
publisher = "BioScientifica Ltd",
number = "6",

}

RIS

TY - JOUR

T1 - Co-localisation of the Kir6.2/SUR1 channel complex with glucagon-like peptide-1 and glucose-dependent insulinotrophic polypeptide expression in human ileal cells and implications for glycaemic control in new onset type 1 diabetes

AU - Nielsen, Lotte B

AU - Ploug, Kenneth B

AU - Swift, Peter

AU - Ørskov, Cathrine

AU - Jansen-Olesen, Inger

AU - Chiarelli, Francesco

AU - Holst, Jens Juul

AU - Hougaard, Philip

AU - Pörksen, Sven

AU - Holl, Reinhard

AU - de Beaufort, Carine

AU - Gammeltoft, Steen

AU - Rorsman, Patrik

AU - Mortensen, Henrik B

AU - Hansen, Lars

AU - Hvidøre Study Group

PY - 2007

Y1 - 2007

N2 - The ATP-dependent K+-channel (K(ATP)) is critical for glucose sensing and normal glucagon and insulin secretion from pancreatic endocrine alpha- and beta-cells. Gastrointestinal endocrine L- and K-cells are also glucose-sensing cells secreting glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotrophic polypeptide (GIP) respectively. The aims of this study were to 1) investigate the expression and co-localisation of the K(ATP) channel subunits, Kir6.2 and SUR1, in human L- and K-cells and 2) investigate if a common hyperactive variant of the Kir6.2 subunit, Glu23Lys, exerts a functional impact on glucose-sensing tissues in vivo that may affect the overall glycaemic control in children with new-onset type 1 diabetes.

AB - The ATP-dependent K+-channel (K(ATP)) is critical for glucose sensing and normal glucagon and insulin secretion from pancreatic endocrine alpha- and beta-cells. Gastrointestinal endocrine L- and K-cells are also glucose-sensing cells secreting glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotrophic polypeptide (GIP) respectively. The aims of this study were to 1) investigate the expression and co-localisation of the K(ATP) channel subunits, Kir6.2 and SUR1, in human L- and K-cells and 2) investigate if a common hyperactive variant of the Kir6.2 subunit, Glu23Lys, exerts a functional impact on glucose-sensing tissues in vivo that may affect the overall glycaemic control in children with new-onset type 1 diabetes.

KW - ATP-Binding Cassette Transporters

KW - Adolescent

KW - Blotting, Western

KW - C-Peptide

KW - Child

KW - Diabetes Mellitus, Type 1

KW - Eating

KW - Female

KW - Gastric Inhibitory Polypeptide

KW - Genotype

KW - Glucagon

KW - Glucagon-Like Peptide 1

KW - Hemoglobin A, Glycosylated

KW - Humans

KW - Hyperglycemia

KW - Hypoglycemic Agents

KW - Ileum

KW - Immunohistochemistry

KW - Insulin

KW - Islets of Langerhans

KW - Male

KW - Polymorphism, Restriction Fragment Length

KW - Potassium Channels

KW - Potassium Channels, Inwardly Rectifying

KW - Receptors, Drug

U2 - 10.1530/EJE-06-0756

DO - 10.1530/EJE-06-0756

M3 - Journal article

VL - 156

SP - 663

EP - 671

JO - European Journal of Endocrinology

JF - European Journal of Endocrinology

SN - 0804-4643

IS - 6

ER -

ID: 34671793