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Co-localisation of the Kir6.2/SUR1 channel complex with glucagon-like peptide-1 and glucose-dependent insulinotrophic polypeptide expression in human ileal cells and implications for glycaemic control in new onset type 1 diabetes

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The ATP-dependent K+-channel (K(ATP)) is critical for glucose sensing and normal glucagon and insulin secretion from pancreatic endocrine alpha- and beta-cells. Gastrointestinal endocrine L- and K-cells are also glucose-sensing cells secreting glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotrophic polypeptide (GIP) respectively. The aims of this study were to 1) investigate the expression and co-localisation of the K(ATP) channel subunits, Kir6.2 and SUR1, in human L- and K-cells and 2) investigate if a common hyperactive variant of the Kir6.2 subunit, Glu23Lys, exerts a functional impact on glucose-sensing tissues in vivo that may affect the overall glycaemic control in children with new-onset type 1 diabetes.
Original languageEnglish
JournalEuropean Journal of Endocrinology
Volume156
Issue number6
Pages (from-to)663-71
Number of pages9
ISSN0804-4643
DOIs
Publication statusPublished - 2007

    Research areas

  • ATP-Binding Cassette Transporters, Adolescent, Blotting, Western, C-Peptide, Child, Diabetes Mellitus, Type 1, Eating, Female, Gastric Inhibitory Polypeptide, Genotype, Glucagon, Glucagon-Like Peptide 1, Hemoglobin A, Glycosylated, Humans, Hyperglycemia, Hypoglycemic Agents, Ileum, Immunohistochemistry, Insulin, Islets of Langerhans, Male, Polymorphism, Restriction Fragment Length, Potassium Channels, Potassium Channels, Inwardly Rectifying, Receptors, Drug

ID: 34671793