Co-circulation of multiple subtypes of enterovirus A71 (EV- A71) genotype C, including novel recombinants characterised by use of whole genome sequencing (WGS), Denmark 2016

Sofie E Midgley; Astrid G Nielsen; Ramona Trebbien; Mille W Poulsen; Peter H Andersen; Thea K Fischer

doi:10.2807/1560-7917.ES.2017.22.26.30565

Co-circulation of multiple subtypes of enterovirus A71 (EV- A71) genotype C, including novel recombinants characterised by use of whole genome sequencing (WGS), Denmark 2016

Sofie E Midgley, Astrid G Nielsen, Ramona Trebbien, Mille W Poulsen, Peter H Andersen, Thea K Fischer

29 Citations (Scopus)

Abstract

In Europe, enterovirus A71 (EV-A71) has primarily been associated with sporadic cases of neurological disease. The recent emergence of new genotypes and larger outbreaks with severely ill patients demonstrates a potential for the spread of new, highly pathogenic EV-A71 strains. Detection and characterisation of these new emerging EV variants is challenging as standard EV assays may not be adequate, necessitating the use of whole genome analysis.

Original language	English
Journal	Eurosurveillance
Volume	22
Issue number	26
ISSN	1560-7917
DOIs	https://doi.org/10.2807/1560-7917.ES.2017.22.26.30565
Publication status	Published - 29 Jun 2017
Externally published	Yes

Keywords

Adolescent
Adult
Child
Child, Preschool
Disease Outbreaks
Enterovirus A, Human/classification
Enterovirus Infections/diagnosis
Feces/virology
Female
Fever/etiology
Genetic Variation
Genome, Viral
Genotype
Humans
Infant
Male
Phylogeny
Sequence Analysis, DNA
Whole Genome Sequencing
Young Adult

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10.2807/1560-7917.ES.2017.22.26.30565

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Co-circulation of multiple subtypes of enterovirus A71 (EV- A71) genotype C, including novel recombinants characterised by use of whole genome sequencing (WGS), Denmark 2016. / Midgley, Sofie E; Nielsen, Astrid G; Trebbien, Ramona et al.
In: Eurosurveillance, Vol. 22, No. 26, 29.06.2017.

Research output: Contribution to journal › Journal article › Research › peer-review

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title = "Co-circulation of multiple subtypes of enterovirus A71 (EV- A71) genotype C, including novel recombinants characterised by use of whole genome sequencing (WGS), Denmark 2016",

abstract = "In Europe, enterovirus A71 (EV-A71) has primarily been associated with sporadic cases of neurological disease. The recent emergence of new genotypes and larger outbreaks with severely ill patients demonstrates a potential for the spread of new, highly pathogenic EV-A71 strains. Detection and characterisation of these new emerging EV variants is challenging as standard EV assays may not be adequate, necessitating the use of whole genome analysis.",

keywords = "Adolescent, Adult, Child, Child, Preschool, Disease Outbreaks, Enterovirus A, Human/classification, Enterovirus Infections/diagnosis, Feces/virology, Female, Fever/etiology, Genetic Variation, Genome, Viral, Genotype, Humans, Infant, Male, Phylogeny, Sequence Analysis, DNA, Whole Genome Sequencing, Young Adult",

author = "Midgley, \{Sofie E\} and Nielsen, \{Astrid G\} and Ramona Trebbien and Poulsen, \{Mille W\} and Andersen, \{Peter H\} and Fischer, \{Thea K\}",

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doi = "10.2807/1560-7917.ES.2017.22.26.30565",

language = "English",

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AU - Midgley, Sofie E

AU - Nielsen, Astrid G

AU - Trebbien, Ramona

AU - Poulsen, Mille W

AU - Andersen, Peter H

AU - Fischer, Thea K

N1 - This article is copyright of The Authors, 2017.

PY - 2017/6/29

Y1 - 2017/6/29

N2 - In Europe, enterovirus A71 (EV-A71) has primarily been associated with sporadic cases of neurological disease. The recent emergence of new genotypes and larger outbreaks with severely ill patients demonstrates a potential for the spread of new, highly pathogenic EV-A71 strains. Detection and characterisation of these new emerging EV variants is challenging as standard EV assays may not be adequate, necessitating the use of whole genome analysis.

AB - In Europe, enterovirus A71 (EV-A71) has primarily been associated with sporadic cases of neurological disease. The recent emergence of new genotypes and larger outbreaks with severely ill patients demonstrates a potential for the spread of new, highly pathogenic EV-A71 strains. Detection and characterisation of these new emerging EV variants is challenging as standard EV assays may not be adequate, necessitating the use of whole genome analysis.

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KW - Adult

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KW - Disease Outbreaks

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KW - Enterovirus Infections/diagnosis

KW - Feces/virology

KW - Female

KW - Fever/etiology

KW - Genetic Variation

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KW - Infant

KW - Male

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DO - 10.2807/1560-7917.ES.2017.22.26.30565

M3 - Journal article

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SN - 1560-7917

VL - 22

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Co-circulation of multiple subtypes of enterovirus A71 (EV- A71) genotype C, including novel recombinants characterised by use of whole genome sequencing (WGS), Denmark 2016

Abstract

Keywords

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