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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Clinical update on contact allergy

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  1. Highlights in allergic contact dermatitis 2018/2019

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. The impact of common metal allergens in daily devices

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  3. Allergen-specific immunotherapy and risk of autoimmune disease

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  4. The current state of recombinant allergens for immunotherapy

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  1. Causative exposures and temporal development of cobalt allergy in Denmark between 2002 and 2017

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  2. Diagnostic workup of occupational allergic nickel dermatitis in a nurse with multiple nickel exposures

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  3. Nickel allergy and allergic contact dermatitis: A clinical review of immunology, epidemiology, exposure, and treatment

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  4. Patch test reactivity to aluminium chambers

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  5. Highlights in allergic contact dermatitis 2018/2019

    Research output: Contribution to journalJournal articleResearchpeer-review

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PURPOSE OF REVIEW: The aim of this article is to review recent findings in contact allergy, regarding clinical research.

RECENT FINDINGS: The biocide methyldibromo glutaronitrile was identified to be an important sensitizer. Subsequently, it was banned from leave-on cosmetics in the European Union. Another group of important allergens that have been studied extensively included the fragrances oak moss absolute, isoeugenol, hydroxyisohexyl 3-cyclohexene carboxaldehyde and farnesol. A new fragrance mix II has been developed for standard testing, which includes the two latter compounds. Dose response studies have demonstrated broad individual variation of elicitation thresholds, dependent on the allergen concentration during induction, and other factors. Some unsuspected routes of exposure to allergens include oral, inhalational, connubial or airborne contact. Experimental studies provide a classification of newly introduced chemicals; increasingly, the local lymph node assay is supplementing and potentially replacing the guinea pig maximization test. Recent advances in occupational contact allergy include, for example, some attempts to improve diagnostics for epoxy resin and other plastic, glue, and cutting fluid components.

SUMMARY: Constant awareness for new allergens, confirmed by critical evaluation, standardization of patch test materials, and the identification of temporal patterns and subgroups at risk will improve both the diagnosis and prevention of allergic contact dermatitis.

Original languageEnglish
JournalCurrent Opinion in Allergy and Clinical Immunology
Volume5
Issue number5
Pages (from-to)429-36
Number of pages8
ISSN1528-4050
Publication statusPublished - Oct 2005

    Research areas

  • Allergens, Animals, Dermatitis, Allergic Contact, Disease Susceptibility, Humans, Immunization, Occupational Diseases, Occupational Exposure, Journal Article, Review

ID: 51611872