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Clinical proteomics: Insights from IGF-I

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Clinical proteomics aims to deliver cost-effective multiplexing of potentially hundreds of diagnostic proteins, including distinct protein isoforms. The analytical strategy known as targeted proteomics is particularly promising because it is compatible with robust mass spectrometry (MS)-platforms already implemented in many clinical laboratories for routine quantitation of small molecules (i.e. uHPLC coupled to triple-quadrupole MS). Progress in targeted proteomics of circulating insulin-like growth factor 1 (IGF-I) have provided valuable insights about tryptic peptides, transitions, internal standards and calibrants. The present challenge is to examine if targeted proteomics of IGF-I can truly measure up to the routine performance that must be expected from a clinical testing platform.

Original languageEnglish
JournalClinica chimica acta; international journal of clinical chemistry
Volume477
Pages (from-to)18-23
Number of pages6
ISSN0009-8981
DOIs
Publication statusPublished - Feb 2018

    Research areas

  • Journal Article, Review

ID: 52794201