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Clinical outcome of percutaneous RF-ablation of non-operable patients with liver metastasis from breast cancer

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PURPOSE: Despite improved anti-neoplastic treatment the prognosis for patients with liver metastases from metastatic breast cancer remains poor.

MATERIALS AND METHODS: Thirty-two consecutive patients with metastatic breast cancer treated with radiofrequency ablation (RFA) at the Department of Oncology, Herlev Hospital, University of Copenhagen, from 1996 to 2010.

RESULTS: Time to intrahepatic progression was median 11 months (range 1.6-184 months). Median survival after first RFA was 33.5 months. Survival at 1, 2 and 3 years was 87, 68 and 48 %, respectively. The local recurrence rate was 22 %.

CONCLUSIONS: In this small, highly selected cohort we found RFA safe and efficacious with a low local recurrence rate and a median survival above that expected with systemic treatment. Our data are in line with previous studies and underscore the need for a large prospective study using optimal chemotherapy regimens and RFA/surgery to clarify whether intense treatment protocols can prolong survival for certain patient groups.

Original languageEnglish
JournalLa Radiologia Medica
Issue number6
Pages (from-to)536-41
Number of pages6
Publication statusPublished - Jun 2015

    Research areas

  • Adult, Aged, Aged, 80 and over, Breast Neoplasms, Catheter Ablation, Female, Follow-Up Studies, Humans, Liver Neoplasms, Middle Aged, Treatment Outcome

ID: 45992151