Clinical importance of neutralising antibodies against interferon beta in patients with relapsing-remitting multiple sclerosis

Per Soelberg Sorensen, Christian Ross, Katja Maria Clemmesen, Klaus Bendtzen, Jette Lautrup Frederiksen, Kai Jensen, Ole Kristensen, Thor Petersen, Soren Rasmussen, Mads Ravnborg, Egon Stenager, Nils Koch-Henriksen, Danish Multiple Sclerosis Study Group

350 Citations (Scopus)

Abstract

Interferon beta is the first-line treatment for relapsing-remitting multiple sclerosis, but the drug can induce neutralising antibodies against itself, which might reduce effectiveness. We aimed to assess the clinical effect of neutralising antibodies.
Original languageEnglish
JournalLancet
Volume362
Issue number9391
Pages (from-to)1184-91
Number of pages8
ISSN0140-6736
DOIs
Publication statusPublished - 11 Oct 2003

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